Prognostic Impact of 18-F-Florbetaben Amyloid PET Imaging in Patients with Isolated Increases in Cerebrospinal Fluid Phospho-Tau Biomarkers: A Longitudinal Study
Keyword(s):
Dsm 5
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This longitudinal study evaluates the prognostic impact of amyloid PET in patients suspected of Alzheimer’s disease and presenting with isolated cerebrospinal fluid (CSF) increases in P-Tau proteins (NCT02556502). The rate of conversion, based on the DSM-5 criteria and all collected data (average follow-up of 39.2±13.2 months), was determined by a panel of experts blinded to the PET results and was 75%(6/8) for positive and 35%(6/17) for negative baseline amyloid PET. In this population with isolated CSF increases in P-Tau, a positive baseline amyloid PET was associated with greater than twice the proportion of dementia conversions within the following three years.
2019 ◽
Vol 68
(3)
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pp. 1061-1069
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2020 ◽
Vol 75
(3)
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pp. 949-958
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2013 ◽
Vol 126
(5)
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pp. 643-657
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2015 ◽
Vol 105
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pp. 66-71
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2014 ◽
Vol 41
(7)
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pp. 1398-1407
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Keyword(s):
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