Classification and enhancement of invasive ductal carcinoma samples using convolutional neural networks

Author(s):  
Edgar E. Sierra-Enriquez ◽  
José E. Valdez-Rodríguez ◽  
Edgardo M. Felipe-Riveró ◽  
Hiram Calvo

In the medical area, the detection of invasive ductal carcinoma is the most common sub-type of all breast cancers; about 80% of all breast cancers are invasive ductal carcinomas. Detection of this type of cancer shows a great challenge for specialist doctors since the digital images of the sample must be analyzed by sections because the spatial dimensions of this kind of image are above 50k × 50k pixels; doing this operation manually takes long time to determine if the patient suffers this type of cancer. Time is essential for the patient because this cancer can invade quickly other parts of the body. Its name reaffirms this characteristic, with the term "invasive" forming part of its name. With the purpose of solving this task, we propose an automatic methodology consisting in improving the performance of a convolutional neural network that classifies images containing invasive ductal carcinoma cells by highlighting cancer cells using several preprocessing methods such as histogram stretching and contrast enhancement. In this way, characteristics of the sub-images are extracted from the panoramic sample and it is possible to learn to classify them in a better way.

Author(s):  
N.T. Abdullaev ◽  
U.N. Musevi ◽  
K.S. Pashaeva

Formulation of the problem. This work is devoted to the use of artificial neural networks for diagnosing the functional state of the gastrointestinal tract caused by the influence of parasites in the body. For the experiment, 24 symptoms were selected, the number of which can be increased, and 9 most common diseases. The coincidence of neural network diagnostics with classical medical diagnostics for a specific disease is shown. The purpose of the work is to compare the neural networks in terms of their performance after describing the methods of preprocessing, isolating symptoms and classifying parasitic diseases of the gastrointestinal tract. Computer implementation of the experiment was carried out in the NeuroPro 0.25 software environment and optimization methods were chosen for training the network: "gradient descent" modified by Par Tan, "conjugate gradients", BFGS. Results. The results of forecasting using a multilayer perceptron using the above optimization methods are presented. To compare optimization methods, we used the values of the minimum and maximum network errors. Comparison of optimization methods using network errors makes it possible to draw the correct conclusion that for the task at hand, the best results were obtained when using the "conjugate gradients" optimization method. Practical significance. The proposed approach facilitates the work of the experimenter-doctor in choosing the optimization method when working with neural networks for the problem of diagnosing parasitic diseases of the gastrointestinal tract from the point of view of assessing the network error.


2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Alexandru Lavric ◽  
Popa Valentin

Keratoconus (KTC) is a noninflammatory disorder characterized by progressive thinning, corneal deformation, and scarring of the cornea. The pathological mechanisms of this condition have been investigated for a long time. In recent years, this disease has come to the attention of many research centers because the number of people diagnosed with keratoconus is on the rise. In this context, solutions that facilitate both the diagnostic and treatment options are quickly needed. The main contribution of this paper is the implementation of an algorithm that is able to determine whether an eye is affected or not by keratoconus. The KeratoDetect algorithm analyzes the corneal topography of the eye using a convolutional neural network (CNN) that is able to extract and learn the features of a keratoconus eye. The results show that the KeratoDetect algorithm ensures a high level of performance, obtaining an accuracy of 99.33% on the data test set. KeratoDetect can assist the ophthalmologist in rapid screening of its patients, thus reducing diagnostic errors and facilitating treatment.


2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Rawan Al khudari ◽  
Mohannad Homsi ◽  
Hasan Al zohaily ◽  
Maher S. Saifo

Bilateral breast cancers are rare cases encountered and are usually the same type in both sides. Only very few cases were reported to have different histological types of neoplasia involving sarcoma. Moreover, sarcomas rarely originate from the breast as a primary lesion whereas the common presentation is having angiosarcoma following radiotherapy. In this report, we present a rare case of a Syrian 43-year-old woman having two distinct primary lesions in the breasts: invasive ductal carcinoma and contralateral stromal sarcoma.


2013 ◽  
Vol 13 (01) ◽  
pp. 1350018 ◽  
Author(s):  
GUANGYING YANG

Electrocardiography (ECG) is a transthoracic interpretation of the electrical activity of the heart over a period of time, as detected by electrodes attached to the outer surface of the skin and recorded by a device external to the body. ECG signal classification is very important for the clinical detection of arrhythmia. This paper presents an application of an improved wavelet neural network structure to the classification of the ECG beats, because of the high precision and fast learning rate. Feature extraction method in this paper is wavelet transform. Our experimental data set is taken from the MIT-BIH arrhythmia database. The correct detection rate of QRS wave is 95% by testing the data of MIT-BIH database. The proposed methods are applied to a large number of ECG signals consisting of 600 training samples and 120 test samples from the MIT-BIH database. The samples equally represent six different ECG signal types, including normal beat, atrial premature beat, ventricular premature beat, left bundle branch block, right bundle branch block and paced beat. In comparison with pattern recognition methods of BP neural networks, RBF neural networks and Support Vector Machines (SVM), the results in this experiment prove that the wavelet neural network method has a better recognition rate when classifying electrocardiogram signals. The experimental results prove that supposed method in this paper is effective for arrhythmia pattern recognition field.


2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Keqin Chen ◽  
Amit Yadav ◽  
Asif Khan ◽  
Yixin Meng ◽  
Kun Zhu

Concrete cracks are very serious and potentially dangerous. There are three obvious limitations existing in the present machine learning methods: low recognition rate, low accuracy, and long time. Improved crack detection based on convolutional neural networks can automatically detect whether an image contains cracks and mark the location of the cracks, which can greatly improve the monitoring efficiency. Experimental results show that the Adam optimization algorithm and batch normalization (BN) algorithm can make the model converge faster and achieve the maximum accuracy of 99.71%.


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