The effects of sensory re-education on hand function recovery after peripheral nerve repair: A systematic review

2021 ◽  
pp. 1-12
Author(s):  
Weili Xia ◽  
Zhongfei Bai ◽  
Rongxia Dai ◽  
Jiaqi Zhang ◽  
Jiani Lu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Peripheral Nerve ◽  
Nerve Repair ◽  
Hand Function ◽  
Current Evidence ◽  
Motor Deficits ◽  
Peripheral Nerve Repair ◽  
Hand Functions ◽  
Function Recovery ◽  
Short And Long Term

BACKGROUND: Peripheral nerve injury can result in both sensory and motor deficits, and these impairments can last for a long period after nerve repair. OBJECTIVE: To systematically review the effects of sensory re-education (SR) on facilitating hand function recovery after peripheral nerve repair. METHODS: This systematic review was limited to articles published from 1970 to 20 December 2020. Electronic searching was performed in CINAHL, Embase, PubMed, Web of Science, and Medline databases to include trials investigating the effects of SR training on hand function recovery after peripheral nerve repair and included only those studies with controlled comparisons. RESULTS: Sixteen articles were included in final data synthesis. We found that only four studies could be rated as having good quality and noted obvious methodological limitations in the remaining studies. The current evidence showed that early SR with mirror visual feedback and the combinational use of classic SR and topical temporary anesthetic seemed to have long- and short-term effects, respectively on improving the sensibility and reducing the disabilities of the hand. The evidence to support the effects of conventional classical SR on improving hand functions was not strong. CONCLUSIONS: Further well-designed trials are needed to evaluate the effects of different SR techniques on hand function after nerve repair over short- and long-term periods.

To reverse or not to reverse? A systematic review of autograft polarity on functional outcomes following peripheral nerve repair surgery

Microsurgery ◽  
2016 ◽  
Vol 37 (2) ◽  
pp. 169-174 ◽  
Author(s):  
S. E. Roberts ◽  
S. Thibaudeau ◽  
J. C. Burrell ◽  
E. L. Zager ◽  
D. K. Cullen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Peripheral Nerve ◽  
Functional Outcomes ◽  
Nerve Repair ◽  
Peripheral Nerve Repair

scholarly journals Insights Into the Role and Potential of Schwann Cells for Peripheral Nerve Repair From Studies of Development and Injury

2021 ◽  
Vol 13 ◽  
Author(s):  
Anjali Balakrishnan ◽  
Lauren Belfiore ◽  
Tak-Ho Chu ◽  
Taylor Fleming ◽  
Rajiv Midha ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Schwann Cells ◽  
Molecular Mechanisms ◽  
Nerve Repair ◽  
Motor Deficits ◽  
Repair Capacity ◽  
Peripheral Nerve Repair ◽  
Cell Replacement

Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self-repair, lifelong disability is common. New molecular and cellular insights have begun to reveal why the peripheral nerve has limited repair capacity. The peripheral nerve is primarily comprised of axons and Schwann cells, the supporting glial cells that produce myelin to facilitate the rapid conduction of electrical impulses. Schwann cells are required for successful nerve regeneration; they partially “de-differentiate” in response to injury, re-initiating the expression of developmental genes that support nerve repair. However, Schwann cell dysfunction, which occurs in chronic nerve injury, disease, and aging, limits their capacity to support endogenous repair, worsening patient outcomes. Cell replacement-based therapeutic approaches using exogenous Schwann cells could be curative, but not all Schwann cells have a “repair” phenotype, defined as the ability to promote axonal growth, maintain a proliferative phenotype, and remyelinate axons. Two cell replacement strategies are being championed for peripheral nerve repair: prospective isolation of “repair” Schwann cells for autologous cell transplants, which is hampered by supply challenges, and directed differentiation of pluripotent stem cells or lineage conversion of accessible somatic cells to induced Schwann cells, with the potential of “unlimited” supply. All approaches require a solid understanding of the molecular mechanisms guiding Schwann cell development and the repair phenotype, which we review herein. Together these studies provide essential context for current efforts to design glial cell-based therapies for peripheral nerve regeneration.

scholarly journals Animal models used to study direct peripheral nerve repair: a systematic review

2020 ◽  
Vol 15 (3) ◽  
pp. 491 ◽  
Author(s):  
FranciscoJavier Vela ◽  
Guadalupe Martínez-Chacón ◽  
Alberto Ballestín ◽  
JoséLuis Campos ◽  
FranciscoMiguel Sánchez-Margallo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Peripheral Nerve ◽  
Nerve Repair ◽  
Peripheral Nerve Repair

Comparison of Collagen and Human Amniotic Membrane Nerve Wraps and Conduits for Peripheral Nerve Repair in Preclinical Models: A Systematic Review of the Literature

2022 ◽  
Author(s):  
Erin M. Wolfe ◽  
Sydney A. Mathis ◽  
Steven A. Ovadia ◽  
Zubin J. Panthaki
Keyword(s):  
Systematic Review ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Amniotic Membrane ◽  
Nerve Repair ◽  
Peripheral Nerve Regeneration ◽  
Human Amniotic Membrane ◽  
Preclinical Models ◽  
Peripheral Nerve Repair ◽  
Advantages And Disadvantages

Abstract Introduction Collagen and human amniotic membrane (hAM) are Food and Drug Administration (FDA)-approved biomaterials that can be used as nerve wraps or conduits for repair of peripheral nerve injuries. Both biomaterials have been shown to reduce scarring and fibrosis of injured peripheral nerves. However, comparative advantages and disadvantages have not been definitively shown in the literature. The purpose of this systematic review is to comprehensively evaluate the literature regarding the roles of hAM and collagen nerve wraps and conduits on peripheral nerve regeneration in preclinical models. Methods The MEDLINE database was queried using the PubMed search engine on July 7, 2019, with the following search strategy: (“amniotic membrane” OR “amnion”) OR (“collagen conduit” OR “nerve wrap”)] AND “nerve.” All resulting articles were screened by two independent reviewers. Nerve type, lesion type/injury model, repair type, treatment, and outcomes were assessed. Results Two hundred and fifty-eight articles were identified, and 44 studies remained after application of inclusion and exclusion criteria. Seventeen studies utilized hAM, whereas 27 studies utilized collagen wraps or conduits. Twenty-three (85%) of the collagen studies utilized conduits, and four (15%) utilized wraps. Six (35%) of the hAM studies utilized conduits and 11 (65%) utilized wraps. Two (9%) collagen studies involving a conduit and one (25%) involving a wrap demonstrated at least one significant improvement in outcomes compared with a control. While none of the hAM conduit studies showed significant improvements, eight (73%) of the studies investigating hAM wraps showed at least one significant improvement in outcomes. Conclusion The majority of studies reported positive outcomes, indicating that collagen and hAM nerve wraps and conduits both have the potential to enhance peripheral nerve regeneration. However, relatively few studies reported significant findings, except for studies evaluating hAM wraps. Preclinical models may help guide clinical practice regarding applications of these biomaterials in peripheral nerve repair.

A Systematic Review on the Use of Fibrin Glue for Peripheral Nerve Repair

2011 ◽  
Vol 127 (6) ◽  
pp. 2381-2390 ◽  
Author(s):  
Mojib Sameem ◽  
Thomas J. Wood ◽  
James R. Bain
Keyword(s):  
Systematic Review ◽  
Peripheral Nerve ◽  
Fibrin Glue ◽  
Nerve Repair ◽  
Peripheral Nerve Repair

scholarly journals Advances of Peripheral Nerve Repair Techniques to Improve Hand Function: A Systematic Review of Literature

2012 ◽  
Vol 6 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Mafi P ◽  
Hindocha S ◽  
Dhital M ◽  
Saleh M
Keyword(s):  
Systematic Review ◽  
Peripheral Nerve ◽  
Neuronal Damage ◽  
Nerve Repair ◽  
Hand Function ◽  
Nerve Transfer ◽  
Nerve Injuries ◽  
External Neurolysis ◽  
Available Information ◽  
Repair Techniques

Concepts of neuronal damage and repair date back to ancient times. The research in this topic has been growing ever since and numerous nerve repair techniques have evolved throughout the years. Due to our greater understanding of nerve injuries and repair we now distinguish between central and peripheral nervous system. In this review, we have chosen to concentrate on peripheral nerve injuries and in particular those involving the hand. There are no reviews bringing together and summarizing the latest research evidence concerning the most up-to-date techniques used to improve hand function. Therefore, by identifying and evaluating all the published literature in this field, we have summarized all the available information about the advances in peripheral nerve techniques used to improve hand function. The most important ones are the use of resorbable poly[(R)-3-hydroxybutyrate] (PHB), epineural end-to-end suturing, graft repair, nerve transfer, side to side neurorrhaphy and end to side neurorrhaphy between median, radial and ulnar nerves, nerve transplant, nerve repair, external neurolysis and epineural sutures, adjacent neurotization without nerve suturing, Agee endoscopic operation, tourniquet induced anesthesia, toe transfer and meticulous intrinsic repair, free auto nerve grafting, use of distal based neurocutaneous flaps and tubulization. At the same time we found that the patient’s age, tension of repair, time of repair, level of injury and scar formation following surgery affect the prognosis. Despite the thorough findings of this systematic review we suggest that further research in this field is needed.

scholarly journals Use of Vein Conduit and Isolated Nerve Graft in Peripheral Nerve Repair: A Comparative Study

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Imran Ahmad ◽  
Md. Sohaib Akhtar
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Hand Function ◽  
Study Groups ◽  
Nerve Graft ◽  
Motor Recovery ◽  
Control Group ◽  
Study Group ◽  
Peripheral Nerve Repair ◽  
Second Year

Aims and Objectives. The aim of this study was to evaluate the effectiveness of vein conduit in nerve repair compared with isolated nerve graft. Materials and Methods. This retrospective study was conducted at author’s centre and included a total of 40 patients. All the patients had nerve defect of more than 3 cm and underwent nerve repair using nerve graft from sural nerve. In 20 cases, vein conduit (study group) was used whereas no conduit was used in other 20 cases. Patients were followed up for 2 years at the intervals of 3 months. Results. Patients had varying degree of recovery. Sensations reached to all the digits at 1 year in study groups compared to 18 months in control group. At the end of second year, 84% patients of the study group achieved 2-point discrimination of <10 mm compared to 60% only in control group. In terms of motor recovery, 82% patients achieved satisfactory hand function in study group compared to 56% in control group (P<.05). Conclusions. It was concluded that the use of vein conduit in peripheral nerve repair is more effective method than isolated nerve graft providing good sensory and motor recovery.

Techniques of Peripheral Nerve Repair

1991 ◽  
Vol 2 (1) ◽  
pp. 93-104 ◽  
Author(s):  
Mark E. Harris ◽  
Suzie C. Tindall
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Peripheral Nerve Repair
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