Functional recovery after experimental spinal cord compression and whole body vibration therapy requires a balanced revascularization of the injured site

2015 ◽  
Vol 33 (2) ◽  
pp. 233-249 ◽  
Author(s):  
M. Manthou ◽  
K. Nohroudi ◽  
S. Moscarino ◽  
F. Rehberg ◽  
G. Stein ◽  
...  
2013 ◽  
Vol 30 (6) ◽  
pp. 453-468 ◽  
Author(s):  
Felicitas Wirth ◽  
Greta Schempf ◽  
Gregor Stein ◽  
Katharina Wellmann ◽  
Marilena Manthou ◽  
...  

Neurology ◽  
2017 ◽  
Vol 89 (6) ◽  
pp. 602-610 ◽  
Author(s):  
Hanwen Liu ◽  
Erin L. MacMillian ◽  
Catherine R. Jutzeler ◽  
Emil Ljungberg ◽  
Alex L. MacKay ◽  
...  

Purpose:To assess the extent of demyelination in cervical spondylotic myelopathy (CSM) using myelin water imaging (MWI) and electrophysiologic techniques.Methods:Somatosensory evoked potentials (SSEPs) and MWI were acquired in 14 patients with CSM and 18 age-matched healthy controls. MWI was performed on a 3.0T whole body magnetic resonance scanner. Myelin water fraction (MWF) was extracted for the dorsal columns and whole cord. SSEPs and MWF were also compared with conventional MRI outcomes, including T2 signal intensity, compression ratio, maximum spinal cord compression (MSCC), and maximum canal compromise (MCC).Results:Group analysis showed marked differences in T2 signal intensity, compression ratio, MSCC, and MCC between healthy controls and patients with CSM. There were no group differences in MWF and SSEP latencies. However, patients with CSM with pathologic SSEPs exhibited reduction in MWF (p < 0.05). MWF was also correlated with SSEP latencies.Conclusion:Our findings provide evidence of decreased myelin content in the spinal cord associated with impaired spinal cord conduction in patients with CSM. While conventional MRI are of great value to define the extent of cord compression, they show a limited correlation with functional deficits (i.e., delayed SSEPs). MWI provides independent and complementary readouts to spinal cord compression, with a high specificity to detect impaired conduction.


Author(s):  
Eduardo Guadarrama-Molina ◽  
Carlos Enrique Barrón-Gámez ◽  
Ingrid Estrada-Bellmann ◽  
Jesús D. Meléndez-Flores ◽  
Paola Ramírez-Castañeda ◽  
...  

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Daniel Collado-Mateo ◽  
Jose C. Adsuar ◽  
Pedro R. Olivares ◽  
Borja del Pozo-Cruz ◽  
Jose A. Parraca ◽  
...  

Objective. To review the literature on the effects of whole-body vibration therapy in patients with fibromyalgia.Design. Systematic literature review.Patients. Patients with fibromyalgia.Methods. An electronic search of the literature in four medical databases was performed to identify studies on whole-body vibration therapy that were published up to the 15th of January 2015.Results. Eight articles satisfied the inclusion and exclusion criteria and were analysed. According to the Dutch CBO guidelines, all selected trials had a B level of evidence. The main outcomes that were measured were balance, fatigue, disability index, health-related quality of life, and pain. Whole-body vibration appeared to improve the outcomes, especially balance and disability index.Conclusion. Whole-body vibration could be an adequate treatment for fibromyalgia as a main therapy or added to a physical exercise programme as it could improve balance, disability index, health-related quality of life, fatigue, and pain. However, this conclusion must be treated with caution because the paucity of trials and the marked differences between existing trials in terms of protocol, intervention, and measurement tools hampered the comparison of the trials.


PM&R ◽  
2012 ◽  
Vol 4 (12) ◽  
pp. 954-962 ◽  
Author(s):  
Stephanie C. Hadi ◽  
Jude J. Delparte ◽  
Sander L. Hitzig ◽  
Beverley Catharine Craven

2012 ◽  
Vol 87 (10) ◽  
pp. E76-E79 ◽  
Author(s):  
Ellen B. Fung ◽  
Catherine A. Gariepy ◽  
Aenor J. Sawyer ◽  
Annie Higa ◽  
Elliott P. Vichinsky

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