scholarly journals Visualizing Food-Drug Interactions in the Thériaque Database

2021 ◽  
Author(s):  
Frédéric Lalanne ◽  
Pierrick Bedouch ◽  
Cyril Simonnet ◽  
Vincent Depras ◽  
Georgeta Bordea ◽  
...  
Keyword(s):  
Health Professional ◽  
Drug Interactions ◽  
Graphical Visualization ◽  
Future Work

This paper presents a prototype for the visualization of food-drug interactions implemented in the MIAM project, whose objective is to develop methods for the extraction and representation of these interactions and to make them available in the Thériaque database. The prototype provides users with a graphical visualization showing the hierarchies of drugs and foods in front of each other and the links between them representing the existing interactions as well as additional details about them, including the number of articles reporting the interaction. The prototype is interactive in the following ways: hierarchies can be easily folded and unfolded, a filter can be applied to view only certain types of interactions, and details about a given interaction are displayed when the mouse is moved over the corresponding link. Future work includes proposing a version more suitable for non-health professional users and the representation of the food hierarchy based on a reference classification.

scholarly journals Potential Adverse Drug Events with Tetrahydrocannabinol (THC) Due to Drug–Drug Interactions

2020 ◽  
Vol 9 (4) ◽  
pp. 919 ◽  
Author(s):  
Joshua D. Brown
Keyword(s):  
Drug Interactions ◽  
Adverse Drug Events ◽  
Alternative Therapy ◽  
Medical Marijuana ◽  
Racial Groups ◽  
Metabolizing Enzymes ◽  
Potential Risks ◽  
Neurological Effects ◽  
Medical Marijuana Use ◽  
Future Work

Tetrahydrocannabinol (THC) is the primary psychoactive ingredient in cannabis. While the safety of THC and cannabis has been extrapolated from millennia of recreational use, medical marijuana programs have increased exposure among medically complex individuals with comorbid conditions and many co-prescribed medications. Thus, THC should be recognized as a pharmacologically complex compound with potential for drug–drug interactions and adverse drug events. This review summarizes potential adverse drug events related to THC when combined with other medications. Metabolic drug–drug interactions are primarily due to THC conversion by CYP3A4 and CYP2C9, which can be impacted by several common medications. Further, CYP2C9 polymorphisms are highly prevalent in certain racial groups (up to 35% in Caucasians) and increase the bioavailability of THC. THC also has broad interactions with drug-metabolizing enzymes and can enhance adverse effects of other medications. Pharmacodynamic interactions include neurological effects, impact on the cardiovascular system, and risk of infection. General clinical recommendations for THC use include starting with low doses and titrating to desired effects. However, many interactions may be unavoidable, dose-limiting, or a barrier to THC-based therapy. Future work and research must establish sufficient data resources to capture medical marijuana use for such studies. Meanwhile, clinicians should balance the potential risks of THC and cannabis and the lack of strong evidence of efficacy in many conditions with patient desires for alternative therapy.

Present status of radio astrometry with baselines ≤ 35 km

1978 ◽  
Vol 48 ◽  
pp. 175-178 ◽  
Author(s):  
K. J. Johnston
Keyword(s):  
Present Status ◽  
Future Work

A summary of results for radio astrometry with baselines ≤ 35 km and priorities for future work are given.

A Phonomotor Approach to Apraxia of Speech Treatment

2020 ◽  
Vol 29 (4) ◽  
pp. 2109-2130
Author(s):  
Lauren Bislick
Keyword(s):  
Phase I ◽  
Treatment Effects ◽  
Single Case ◽  
Motor Planning ◽  
The Other ◽  
Multimodal Approach ◽  
Apraxia Of Speech ◽  
Duration Of Treatment ◽  
Treatment Gains ◽  
Future Work

Purpose This study continued Phase I investigation of a modified Phonomotor Treatment (PMT) Program on motor planning in two individuals with apraxia of speech (AOS) and aphasia and, with support from prior work, refined Phase I methodology for treatment intensity and duration, a measure of communicative participation, and the use of effect size benchmarks specific to AOS. Method A single-case experimental design with multiple baselines across behaviors and participants was used to examine acquisition, generalization, and maintenance of treatment effects 8–10 weeks posttreatment. Treatment was distributed 3 days a week, and duration of treatment was specific to each participant (criterion based). Experimental stimuli consisted of target sounds or clusters embedded nonwords and real words, specific to each participants' deficit. Results Findings show improved repetition accuracy for targets in trained nonwords, generalization to targets in untrained nonwords and real words, and maintenance of treatment effects at 10 weeks posttreatment for one participant and more variable outcomes for the other participant. Conclusions Results indicate that a modified version of PMT can promote generalization and maintenance of treatment gains for trained speech targets via a multimodal approach emphasizing repeated exposure and practice. While these results are promising, the frequent co-occurrence of AOS and aphasia warrants a treatment that addresses both motor planning and linguistic deficits. Thus, the application of traditional PMT with participant-specific modifications for AOS embedded into the treatment program may be a more effective approach. Future work will continue to examine and maximize improvements in motor planning, while also treating anomia in aphasia.

Derm Drug Interactions: Top Ten to Watch For

2006 ◽  
Vol 37 (3) ◽  
pp. 21
Author(s):  
NANCY WALSH
Keyword(s):  
Drug Interactions

Confirmatory Factor Analysis of the Long and Short Forms of the Worry Domains Questionnaire

2009 ◽  
Vol 25 (4) ◽  
pp. 239-243
Author(s):  
Roberto Nuevo ◽  
Andrés Losada ◽  
María Márquez-González ◽  
Cecilia Peñacoba
Keyword(s):  
Factor Analysis ◽  
Confirmatory Factor Analysis ◽  
Factor Structure ◽  
Goodness Of Fit ◽  
Factorial Validity ◽  
Fit Indices ◽  
Short Forms ◽  
Confirmatory Factor ◽  
Positive Correlations ◽  
Future Work

The Worry Domains Questionnaire was proposed as a measure of both pathological and nonpathological worry, and assesses the frequency of worrying about five different domains: relationships, lack of confidence, aimless future, work, and financial. The present study analyzed the factor structure of the long and short forms of the WDQ (WDQ and WDQ-SF, respectively) through confirmatory factor analysis in a sample of 262 students (M age = 21.8; SD = 2.6; 86.3% females). While the goodness-of-fit indices did not provide support for the WDQ, good fit indices were found for the WDQ-SF. Furthermore, no source of misspecification was identified, thus, supporting the factorial validity of the WDQ-SF scale. Significant positive correlations between the WDQ-SF and its subscales with worry (PSWQ), anxiety (STAI-T), and depression (BDI) were found. The internal consistency was good for the total scale and for the subscales. This work provides support for the use of the WDQ-SF, and potential uses for research and clinical purposes are discussed.

Assessing Social Skills in Health Professional Services

2005 ◽  
Vol 21 (3) ◽  
pp. 173-181
Author(s):  
Francisco Gil ◽  
Jesús Sanz ◽  
María Paz García-Vera ◽  
José M. León ◽  
Silvia Medina ◽  
...  
Keyword(s):  
Social Skills ◽  
Health Services ◽  
Health Professional ◽  
Aggressive Behavior ◽  
Psychometric Properties ◽  
Internal Consistency ◽  
Intervention Program ◽  
Professional Services ◽  
Quality Of Health Services

Abstract. The quality of health services depends on the contribution of all the professionals involved in the system, including certain groups, usually forgotten and underrated, such as the health-transport technicians (HTT). With the aim of improving this group's performance, an intervention program, focusing on the development of the workers' technical and social skills, was designed in a collective of enterprises. Information about the first stage of this program, consisting of the assessment of these workers' social skills, is offered in this study. A specific questionnaire was developed: The Health-Transport Technicians Social Skills Questionnaire (HTT-SSQ), made up of three scales (assertive, passive, and aggressive behavior). It was administered to a large sample (N = 530) from the above-mentioned association. The psychometric properties of the questionnaire were analyzed, with quite satisfactory indexes of internal consistency and factor validity, and the group's deficiencies (excess or deficit) were evaluated.

Psychology in Outerspace

2010 ◽  
Vol 15 (3) ◽  
pp. 220-228 ◽  
Author(s):  
Viren Swami ◽  
Tomas Chamorro-Premuzic ◽  
Manal Shafi
Keyword(s):  
Individual Difference ◽  
Sensation Seeking ◽  
Structural Equation ◽  
Political Orientation ◽  
Equation Modeling ◽  
Big Five Personality ◽  
Social Conformity ◽  
Extraterrestrial Life ◽  
Paranormal Beliefs ◽  
Future Work

Previous work has shown that is important to consider the disjunction between paranormal and nonparanormal beliefs about extraterrestrial life. The current study examined the association between both such beliefs and individual difference and demographic variables. A total of 555 British participants completed the Extraterrestrial Beliefs Scale, as well as measures of their Big Five personality scores, social conformity, sensation seeking, and demographics. Results showed no sex differences in ratings of paranormal and nonparanormal extraterrestrial beliefs, but participants rated nonparanormal beliefs more positively than paranormal beliefs. Results of structural equation modeling showed that individual difference factors (specifically, Openness, Conscientiousness, and social conformity) explained 21% of the variance in extraterrestrial beliefs, whereas demographic factors (specifically, education level, political orientation, and religiosity) explained 16% of the variance. Limitations and directions for future work are considered.

Healthy Behavior for the Health Professional

1982 ◽  
Vol 27 (4) ◽  
pp. 307-308
Author(s):  
Eric Button
Keyword(s):  
Health Professional ◽  
Healthy Behavior

The Law and the Mental Health Professional

1984 ◽  
Vol 29 (9) ◽  
pp. 701-702
Author(s):  
R. Matthew Reese ◽  
Jan B. Sheldon
Keyword(s):  
Mental Health ◽  
Health Professional ◽  
Mental Health Professional ◽  
The Law
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