scholarly journals Surface-active agents from the group of polyoxyethylated glycerol esters of fatty acids. Part IV. Equilibrium micellar solubilization of selected lipophilic therapeutic agents (BCS class II and III) in aqueous solutions of products of catalytic oxyethylation of triglyceride fractions extracted from pharmacopoeial lard (Adeps suillus PP XI) of nTE≥50

2019 ◽  
Vol 76 (4) ◽  
pp. 707-714
Author(s):  
Zbigniew Marczyński ◽  
Michał Kołodziejczyk ◽  
Michał Nachajski ◽  
Marian Zgoda
Keyword(s):  
Fatty Acids ◽  
Aqueous Solutions ◽  
Class Ii ◽  
Therapeutic Agents ◽  
Micellar Solubilization ◽  
Bcs Class Ii ◽  
Surface Active Agents ◽  
Surface Active

Further studies ofSchistosoma mansonicercarial stimulation by crude egg lecithin and other lipids

Parasitology ◽  
1974 ◽  
Vol 69 (3) ◽  
pp. 455-463 ◽  
Author(s):  
F. Austin ◽  
P. Frappaolo ◽  
B. Gilbert ◽  
W. Landis ◽  
M. N. da Rosa ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fatty Acids ◽  
Oleic Acid ◽  
Unsaturated Fatty Acids ◽  
Carboxyl Groups ◽  
Highly Active ◽  
Surface Active Agents ◽  
Egg Lecithin ◽  
Surface Active ◽  
Pure Cholesterol

The stimulus provided to cercariae by the skin fat of their definitive hosts is not the same forSchistosoma mansoniandAustrobilharzia terrigalensis.Cercariae of the former parasite are stimulated by unsaturated fatty acids, those of the latter by cholesterol.A reinvestigation of the penetration stimulant factors present in crude egg lecithin, which contains both cholesterol and free fatty acids as impurities, has shown that the latter are responsible for the stimulus inS. mansoni.The phospholipid fraction is inactive as is pure cholesterol. A little excitation of cercariae is produced by the monoglyceride fraction. These results fully confirm earlier findings.Of surface active agents other than lecithin, stimulatory activity was found only in one product which possessed carboxyl groups. Of the C18acids examined, stearic (18:0) is inactive, oleic (18:1) slightly active, linoleic (18:2) and linolenic (18:3) acids highly active. Oleic acid was shown by GC-mass spectrometry to be the most abundant acid in crude egg lecithin and is probably the main penetration stimulus present.

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