scholarly journals Intrahepatic Bile Duct Biliary Intraepithelial Neoplasia

2020 ◽  
Author(s):  
Keyword(s):  
Bile Duct ◽  
Intrahepatic Bile Duct ◽  
Intraepithelial Neoplasia ◽  
Biliary Intraepithelial Neoplasia

scholarly journals Pure Laparoscopic Left Hemihepatectomy for Hepatic Peribiliary Cysts with Biliary Intraepithelial Neoplasia

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Akira Umemura ◽  
Takayuki Suto ◽  
Akira Sasaki ◽  
Hiroyuki Nitta ◽  
Seika Nakamura ◽  
...  
Keyword(s):  
Bile Duct ◽  
Intrahepatic Bile Duct ◽  
Invasive Procedure ◽  
Intraepithelial Neoplasia ◽  
Class Iii ◽  
Biliary Intraepithelial Neoplasia ◽  
Left Hemihepatectomy ◽  
Peribiliary Glands ◽  
Peribiliary Cysts ◽  
Enhanced Computed Tomography

Introduction. Hepatic peribiliary cysts (HPCs) usually originate due to the cystic dilatation of the intrahepatic extramural peribiliary glands. We describe our rare experience of pure laparoscopic left hemihepatectomy (PLLH) in a patient with HPCs accompanied by a component of biliary intraepithelial neoplasia (BilIN).Case Presentation. A 65-year-old man was referred for further investigation of mild hepatic dysfunction. Contrast-enhanced computed tomography showed dilatation of the left-sided intrahepatic bile duct, and biliary cytology showed class III cells. The patient was highly suspected of having left side-dominated cholangiocarcinoma and underwent PLLH. Microscopic findings revealed multiple cystic dilatations of the extramural peribiliary glands; hence, this lesion was diagnosed as HPCs. The resected intrahepatic bile duct showed that the normal ductal lumen comprised low columnar epithelia; however, front formation on the BilIN was observed in some parts of the intrahepatic bile duct, indicating that the BilIN coexisted with HPCs.Conclusion.We chose surgical therapy for this patient owing to the presence of some features of biliary malignancy. We employed noble PLLH as a minimally invasive procedure for this patient.

scholarly journals Precursors to Cholangiocarcinoma

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Tomas Hucl
Keyword(s):  
Bile Duct ◽  
Natural History ◽  
Biliary Tract ◽  
Intraepithelial Neoplasia ◽  
Mucinous Cystic Neoplasm ◽  
Cystic Neoplasm ◽  
Biliary Tract Cancers ◽  
Biliary Intraepithelial Neoplasia ◽  
Prevention And Early Detection ◽  
Duct Cancer

Cancers of the biliary tract include intra- and extrahepatic cholangiocarcinomas and gallbladder cancer. Biliary tract cancers are diseases with unfavorable prognoses. In recent years, several lesions have been described as precursors that precede biliary cancers. They include flat and microscopic lesions known as biliary intraepithelial neoplasia, macroscopic and tumor-forming intraductal papillary biliary neoplasia, intraductal tubular neoplasia, and mucinous cystic neoplasm of the bile duct. These conditions are rarely diagnosed, while their natural history and progression to cancer have yet to be adequately characterized. This review examines the epidemiology, pathology, molecular biology, diagnosis, and therapy of these various precursors. Further research is required if we are to better understand this evolving field and improve the prevention and early detection of bile duct cancer.

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