scholarly journals Anti-CD123-Pyrrolobenzodiazepine Dimer Antibody Drug Conjugate SGN-CD123A

2020 ◽  
Author(s):  
Keyword(s):  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Pyrrolobenzodiazepine Dimer ◽  
Antibody Drug

SGN-CD33A: a novel CD33-targeting antibody–drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML

Blood ◽  
2013 ◽  
Vol 122 (8) ◽  
pp. 1455-1463 ◽  
Author(s):  
May S. Kung Sutherland ◽  
Roland B. Walter ◽  
Scott C. Jeffrey ◽  
Patrick J. Burke ◽  
Changpu Yu ◽  
...  
Keyword(s):  
Cross Linking ◽  
Drug Resistant ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Poor Risk ◽  
Highly Active ◽  
Key Points ◽  
Pyrrolobenzodiazepine Dimer ◽  
Antibody Drug

Key PointsSGN-CD33A is a novel antibody-drug conjugate, consisting of an engineered anti-CD33 mAb conjugated to a potent DNA cross-linking cytotoxin. SGN-CD33A is highly active in a broad panel of preclinical AML models and, in contrast to GO, is active despite MDR or poor-risk cytogenetics.

scholarly journals cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody–Drug Conjugate Targeting c-Met Overexpression Tumors

ACS Omega ◽  
2020 ◽  
Vol 5 (40) ◽  
pp. 25798-25809
Author(s):  
Byeongkwi Min ◽  
Jonghwa Jin ◽  
Hyeree Kim ◽  
Nam-Gu Her ◽  
Changsik Park ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Antibody Drug Conjugate ◽  
Site Specific ◽  
Drug Conjugate ◽  
Pyrrolobenzodiazepine Dimer ◽  
Antibody Drug

Synthesis and in vitro evaluation of SG3227, a pyrrolobenzodiazepine dimer antibody-drug conjugate payload based on sibiromycin

2017 ◽  
Vol 27 (5) ◽  
pp. 1154-1158 ◽  
Author(s):  
Gary C. Kemp ◽  
Arnaud C. Tiberghien ◽  
Neki V. Patel ◽  
Francois D'Hooge ◽  
Sanjay M. Nilapwar ◽  
...  
Keyword(s):  
Antibody Drug Conjugate ◽  
In Vitro Evaluation ◽  
Drug Conjugate ◽  
Pyrrolobenzodiazepine Dimer ◽  
Antibody Drug

scholarly journals Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload

2016 ◽  
Vol 7 (11) ◽  
pp. 983-987 ◽  
Author(s):  
Arnaud C. Tiberghien ◽  
Jean-Noel Levy ◽  
Luke A. Masterson ◽  
Neki V. Patel ◽  
Lauren R. Adams ◽  
...  
Keyword(s):  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Design And Synthesis ◽  
Pyrrolobenzodiazepine Dimer ◽  
Antibody Drug
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