scholarly journals Giant Cell Tumor of the Maxilla

2012 ◽  
Vol 27 (2) ◽  
pp. 24-27 ◽  
Author(s):  
Somnath Saha ◽  
Sharmila Sen ◽  
V. Padmini Saha ◽  
Sudipta Pal
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Surgical Excision ◽  
Cell Tumor ◽  
Radiological Investigation ◽  
Inferior Aspect ◽  
Biopsy Report ◽  
Long Term Follow Up ◽  
Private Teaching ◽  
The Right

Objective: To present a rare case of maxillary swelling; its investigation and management.   Methods: Design: Case Report   Setting: Tertiary Rural Private Teaching Hospital   Patient: One   Results: A 45-year-old female presented with a right maxillary swelling of six months duration. Radiological investigation revealed a radiolucent lesion arising from the inferior aspect of the right maxilla with no areas of calcification. Incisional biopsy report was consistent with giant cell tumor. The mass was excised via a Weber Ferguson incision under general anesthesia. Conclusion: Though rare, giant cell tumor should be considered as one of the differential diagnosis in cases of maxillary swelling. Adequate surgical excision with long-term follow-up should be the treatment of choice for managing a giant cell lesion of the maxilla.   Keywords: maxillary swelling, giant cell tumor

scholarly journals Giant Cell Tumor of Bone: A rare uncommon manifestation implicated in a new mosaic of desorders?

2021 ◽  
Author(s):  
Eliandro de Souza Freitas ◽  
Francisco Amadis Batista Ferreira ◽  
Brendo Vinícius Rodrigues Louredo ◽  
Milena Gomes Melo Leite ◽  
José da Cruz Luna Neto ◽  
...  
Keyword(s):  
Maxillary Sinus ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Rare Case ◽  
Benign Neoplasm ◽  
Cell Tumor ◽  
Long Bones ◽  
The Right

Giant Cell Tumor of Bone is an uncommon aggressive benign neoplasm that frequently affecting the epiphysis of long bones especially around the knee. This is a singular rare case of GCTB in the right maxillary sinus implicated in a process coincidentally or casually with another type of lesion primarily developed.

scholarly journals Giant Cell Tumor of Bone: Oncological and Functional Results of Long-term Follow-up

1998 ◽  
Vol 28 (5) ◽  
pp. 323-328 ◽  
Author(s):  
Y. Oda ◽  
H. Miura ◽  
M. Tsuneyoshi ◽  
Y. Iwamoto
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Functional Results ◽  
Cell Tumor ◽  
Long Term Follow Up

scholarly journals Brown Tumor of the Facial Bones: Case Report and Literature Review

2005 ◽  
Vol 84 (7) ◽  
pp. 432-434 ◽  
Author(s):  
Marcus M. Lessa ◽  
Flavio A. Sakae ◽  
Robinson K. Tsuji ◽  
Bernardo C. Araújo Filho ◽  
Richard L. Voegels ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Surgical Resection ◽  
Tumor Regression ◽  
Cell Tumor ◽  
Nasal Fossa ◽  
Laboratory Evaluation ◽  
Direct Result ◽  
Brown Tumor ◽  
The Right

Brown tumor, an uncommon focal giant-cell lesion, arises as a direct result of the effect of parathyroid hormone on bone tissue in patients with hyperparathyroidism. The initial treatment involves the correction of hyperparathyroidism, which usually leads to tumor regression. We report a case of brown tumor of the right nasal fossa in a 71-year-old woman. The tumor had caused nasal obstruction and epistaxis. Laboratory evaluation revealed that the patient had primary hyperparathyroidism. Anatomicopathologic investigation revealed the presence of a giant-cell tumor. We performed a partial parathyroidectomy, but the tumor in the right nasal fossa failed to regress. One year later, we performed surgical resection of the lesion. The patient recovered uneventfully, and she remained asymptomatic and recurrence-free at the 1-year follow-up. Facial lesions with histologic features of a giant-cell tumor should be evaluated from a systemic standpoint. Hyperparathyroidism should always be investigated by laboratory tests because most affected patients are asymptomatic. Surgical resection of a brown tumor should be considered if the mass does not regress after correction of the inciting hyperparathyroidism or if the patient is highly symptomatic.

scholarly journals Pexidartinib: first approved systemic therapy for patients with tenosynovial giant cell tumor

2020 ◽  
Vol 16 (29) ◽  
pp. 2345-2356 ◽  
Author(s):  
Hans Gelderblom ◽  
Michiel van de Sande
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Kinase Inhibitor ◽  
Functional Limitations ◽  
Cell Tumor ◽  
Phase Iii ◽  
Tenosynovial Giant Cell Tumor ◽  
Study Results ◽  
Long Term Follow Up ◽  
Us Fda

Pexidartinib is an orally administered small molecule tyrosine kinase inhibitor. Phase III ENLIVEN study results provided clinical evidence for US FDA approval for treatment of adult patients with symptomatic tenosynovial giant cell tumor associated with severe morbidity or functional limitations and not amenable to improvement with surgery. Recommended dosage is 400 mg orally twice daily on an empty stomach. Long-term follow-up in pooled analyses showed increased response rates compared with those observed in ENLIVEN. Patients on pexidartinib also experience meaningful improvements in range of motion. Side effects associated with pexidartinib are generally manageable; however, there is a risk of potentially life-threatening mixed or cholestatic hepatotoxicity and pexidartinib has a Risk Evaluation and Mitigation Strategy (REMS) program to ensure appropriate monitoring.

Carcinosarcomatous malignancy, osteosarcoma and squamous cell carcinoma, in giant cell tumor of the right distal femur

2008 ◽  
Vol 204 (8) ◽  
pp. 583-588 ◽  
Author(s):  
Rikuo Machinami ◽  
Kazunori Nishida ◽  
Tsuyoshi Ishida ◽  
Seiichi Matsumoto ◽  
Kouji Kuroda ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Squamous Cell ◽  
Distal Femur ◽  
Cell Tumor ◽  
The Right

scholarly journals Giant Cell Tumor of the Carotid Body: A Rare Tumor in a Novel Location

2019 ◽  
Vol 98 (3) ◽  
pp. 165-168
Author(s):  
Payal Chowdhary ◽  
Gabriel S. Makar ◽  
Thomas Holdbrook ◽  
Thomas C. Spalla
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Carotid Body ◽  
Soft Tissues ◽  
Surgical Excision ◽  
Cell Tumor ◽  
Biological Behavior ◽  
Complete Excision ◽  
Tissue Equivalent

Primary giant cell tumor of soft tissue (GCT-ST) is a rare entity that is considered the soft tissue equivalent of giant cell tumor of bone. It most commonly arises in soft tissues of the trunk and extremities, with occurrence in the head and neck being extremely rare. We report a case of GCT-ST of the carotid body, the first report of a tumor of this kind arising from this site in the neck. Giant cell tumor of soft tissue is generally considered a benign tumor with low malignant potential; thus, surgical excision is usually curative. However, due to the location and invasive nature of this patient’s tumor, complete excision was not possible. We discuss the implication of this for long-term management of this patient, as well as similarities and differences in clinical presentation, histology, and biological behavior between this case and previously reported cases of GCT-ST.

Aggressive Osteoclastoma of Sphenoid Sinus: A Rare Surgical Case Report

2016 ◽  
Vol 8 (2) ◽  
pp. 68-71 ◽  
Author(s):  
Narendra Kumar ◽  
G Sundhar Krishnan
Keyword(s):  
Case Report ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Sphenoid Sinus ◽  
Benign Tumor ◽  
Cell Tumor ◽  
The Body ◽  
Radiological Investigation ◽  
Surgical Case ◽  
Temporal Bones

ABSTRACT The giant cell tumor (GCT) or osteoclastoma is considered to be a locally aggressive benign tumor. The GCTs of the cranium represent only 1% of all GCTs and preferentially affect the sphenoid and temporal bones. We report a case of an 18-year-old male who presented with headache and diplopia. Radiological investigation shows a destructive midline mass involving the body of the sphenoid. The tumor was debulked endoscopically and histopathology reported as osteoclastoma of sphenoid sinus. Radiotherapy and zoledronate was given. We report this case due to its extreme aggressive nature of growth, which is a challenge to treat, and unique presentation in teenaged male, which is rare. How to cite this article Krishnan GS, Kumar N. Aggressive Osteoclastoma of Sphenoid Sinus: A Rare Surgical Case Report. Int J Otorhinolaryngol Clin 2016;8(2):68-71.

scholarly journals The Giant Cell Tumor, Appeared in the Sacrum Seven Years After the Amptuation of the Right Humerus

1978 ◽  
Vol 27 (3) ◽  
pp. 454-456
Author(s):  
R. Nakagawa ◽  
N. Takagishi ◽  
S. Yo ◽  
M. Kikuchi ◽  
A. Nishio ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
The Right

Giant Cell Tumor of the Tendon Sheath Around the Foot and Ankle

2015 ◽  
Vol 105 (3) ◽  
pp. 249-254 ◽  
Author(s):  
Gauresh Vargaonkar ◽  
Vikramadittya Singh ◽  
Sumit Arora ◽  
Abhishek Kashyap ◽  
Vikas Gupta ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Surgical Excision ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Flexor Hallucis Longus ◽  
Rare Clinical Entity ◽  
Foot And Ankle ◽  
Peroneus Brevis

The foot and ankle are rare sites of involvement for giant cell tumor of tendon sheath. We present three rare cases of giant cell tumor of tendon sheath arising from the tendon sheaths of the flexor hallucis longus, peroneus brevis, and extensor hallucis brevis tendons, along with a literature review of such cases in the foot and ankle region. All of the patients were treated with surgical excision of the mass and were asymptomatic after minimum follow-up of 18 months. Giant cell tumor of tendon sheath involving the foot and ankle region is a rare clinical entity, and good results can be expected after surgical excision.

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