scholarly journals Maxillary Sinus Squamous Cell Carcinoma in a Tertiary Hospital in the Philippines

2019 ◽  
Vol 34 (1) ◽  
pp. 34-37
Author(s):  
Anna Kristina M. Hernandez ◽  
Arsenio Claro A. Cabungcal
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Maxillary Sinus ◽  
General Hospital ◽  
Squamous Cell ◽  
Case Series ◽  
The Philippines ◽  
Chief Complaint ◽  
Initial Symptoms ◽  
Sinus Cancer

Objective: To establish preliminary demographic and clinicopathologic data on Maxillary Sinus Squamous Cell Carcinoma (SCC) in the Philippine General Hospital Methods:                  Design:           Retrospective Case Series           Setting:           Tertiary National University Hospital           Participants: Socio-demographic and clinical data from records of 22 patients admitted at the Department of Otorhinolaryngology of the Philippine General Hospital from 2013-2016 and histopathologically confirmed to have Maxillary Sinus SCC, were collected and described using means and proportions. Results: There were 15 males and 7 females with a mean age of 50-years-old (range 24 to 77-years-old). Maxillary mass/swelling was the most common chief complaint.  The mean gap between initial symptoms and consult was 6.77 months.  Initial biopsies were obtained from the maxillary sinus in 16 patients, with 1 patient noted to have undergone malignant transformation from a prior intranasal squamous papilloma.  Staging was advanced (Stage IVA in 16, IVB in 4, and III in 2), with no patients with Stage I or II disease.  Sixteen (16) patients underwent surgery and radiotherapy, while 6 patients received radiotherapy (RT) with or without chemotherapy.  Regional and distant metastases were uncommon. Conclusion: In this series, maxillary sinus SCC occurs more in males, with a maxillary mass as the most common chief complaint.  Delay in treatment is common, with a mean gap of 6 months between initial symptoms and consult.  Neck node metastasis is uncommon, and most patients undergo surgery with radiotherapy as treatment.   Keywords: maxillary sinus cancer; paranasal sinus cancer; squamous cell carcinoma  

ANALYSIS OF EXPRESSION OF P63 AND CASPASE-3 AND THEIR PREDICTIVE VALUE IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF MAXILLARY SINUS

2019 ◽  
Vol 72 (12) ◽  
Author(s):  
Oleksandr V Kovtunenko ◽  
Anatoliy A Bakaiev ◽  
Ihor S Shponka
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Maxillary Sinus ◽  
Squamous Cell ◽  
Predictive Value ◽  
Caspase 3 ◽  
High Expression ◽  
Malignant Neoplasms ◽  
Maxillary Sinus Cancer ◽  
Sinus Cancer

Introduction: Maxillary sinus cancer is a malignant neoplasm with a prevalence of 3 to 5% of tumors in the head and neck and less than 1% of all malignant neoplasms. The role of p63 and caspase-3 and their predictive value in squamous cell carcinoma of maxillary sinus (SCCMS) remains an underdeveloped and controversial issue that determined the relevance of the study. The aim: To analyze the relationship between the level of expression of p63 and caspase-3 and clinical and morphological characteristics of squamous cell carcinoma of maxillary sinus and to determine their prognostic significance as immunohistochemical markers of tumor progression (relapse and metastases). Materials and methods: A comprehensive investigation with immunohistochemical study of squamous cell carcinoma of maxillary sinus of 103 patients with maxillary sinus cancer II - IV stage (T2-4 N0-3 M0) of the second clinical group was conducted. Results: The moderate and high expression rate of caspase-3 in the overall sample was 50.49% and 16.50% respectively, and one third of cases (33.01%) was characterized by a weak reaction. In the group without metastases (p <0.001), moderate expression of the marker (56.25%) prevailed; in the SCCMS group with metastases it was (60.87%). The mean level of expression of p63 in the examined patients with squamous cell carcinoma of maxillary sinus was 46.0%. The number of p63-positive specimens was statistically significantly (p = 0.034) higher in the SCCMS group with metastases. In patients with the development of squamous cell carcinoma of maxilla on the background of papilloma, a significantly higher (p <0.001) mean level of p63 expression was only moderate (90.91%) and high (9.09%). Conclusions: There was observed a relatively strong associate of the increase in the expression of caspase-3 with SCCMS metastases (p <0.001) and no correlation of immunohistochemical reaction of this marker with relapses. There was determined that the probability of metastases at high expression level of p63 is higher than in tumors with low and moderate level of the oncoprotein (p = 0.003). Based on the level of expression of p63, it is possible to predict the likelihood of development of SCCMS with papillomas (p <0.001); and the development of relapses of squamous cell carcinoma of maxillary sinus (p <0.001).

Squamous Cell Carcinoma of Bladder Diverticulum with Initial Symptoms Produced by Metastasis to Maxillary Sinus

1988 ◽  
Vol 15 (3-4) ◽  
pp. 285-286 ◽  
Author(s):  
Akihito Nanbu ◽  
Taiji Tsukamoto ◽  
Yoshiaki Kumamoto ◽  
Masaharu Aoki ◽  
Takaoki Hirose ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Maxillary Sinus ◽  
Squamous Cell ◽  
Bladder Diverticulum ◽  
Initial Symptoms

scholarly journals Local Chemotherapy as an Adjuvant Treatment in Unresectable Squamous Cell Carcinoma: What Do We Know So Far?

2021 ◽  
Vol 28 (4) ◽  
pp. 2317-2325
Author(s):  
Luigi Bennardo ◽  
Francesco Bennardo ◽  
Amerigo Giudice ◽  
Maria Passante ◽  
Stefano Dastoli ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Gold Standard ◽  
Systemic Chemotherapy ◽  
Standard Treatment ◽  
Case Reports ◽  
Case Series ◽  
Surgical Removal ◽  
Local Chemotherapy

Background: Squamous cell carcinoma (SCC) is one of the most common cancers involving skin and oral mucosa. Although this condition’s gold-standard treatment is the surgical removal of the lesions, the physician must propose alternative treatments in some cases due to the patient’s ineligibility for surgery. Among the available alternative therapies, local chemotherapy may represent an initial treatment in combination with radiotherapy or systemic chemotherapy due to the low frequency of side-effects and the lack of necessity for expensive devices. Methods: In this paper, we review all available literature in various databases (PubMed, Scopus-Embase, Web of Science), proposing local chemotherapy as a treatment for cutaneous and oral SCC. Exclusion criteria included ocular lesions (where topical treatments are common), non-English language, and non-human studies. Results: We included 14 studies in this review. The majority were case reports and case series describing the treatment of non-resectable localized SCC with either imiquimod or 5-fluorouracil. We also analyzed small studies proposing combination treatments. Almost all studies reported an excellent clinical outcome, with a low risk of relapses in time. Conclusions: Resection of the lesion remains the gold-standard treatment for SCC. When this approach is not feasible, local chemotherapy may represent a treatment alternative, and it may also be associated with radiotherapy or systemic chemotherapy.

HLA class I antigen defects in maxillary sinus squamous cell carcinoma: potential prognostic significance

2003 ◽  
Vol 1240 ◽  
pp. 487-488 ◽  
Author(s):  
Nobuyuki Bandoh ◽  
Takeshi Ogino ◽  
Tatsuya Hayashi ◽  
Satoshi Nonaka ◽  
Yasuaki Harabuchi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Maxillary Sinus ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Hla Class I ◽  
Class I ◽  
Hla Class I Antigen

scholarly journals Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jeffrey A. How ◽  
Amir A. Jazaeri ◽  
Pamela T. Soliman ◽  
Nicole D. Fleming ◽  
Jing Gong ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Phase Ii ◽  
Squamous Cell ◽  
Single Agent ◽  
Case Series ◽  
Predictive Biomarkers ◽  
Vulvar Squamous Cell Carcinoma ◽  
Metastatic Setting ◽  
Progression Of Disease

AbstractVaginal and vulvar squamous cell carcinoma (SCC) are rare tumors that can be challenging to treat in the recurrent or metastatic setting. We present a case series of patients with vaginal or vulvar SCC who were treated with single-agent pembrolizumab as part of a phase II basket clinical trial to evaluate efficacy and safety. Two cases of recurrent and metastatic vaginal SCC, with multiple prior lines of systemic chemotherapy and radiation, received pembrolizumab. One patient had significant reduction (81%) in target tumor lesions prior to treatment discontinuation at cycle 10 following confirmed progression of disease with new metastatic lesions (stable disease by irRECIST criteria). In contrast, the other patient with vaginal SCC discontinued treatment after cycle 3 due to disease progression. Both patients had PD-L1 positive vaginal tumors and tolerated treatment well. One case of recurrent vulvar SCC with multiple surgical resections and prior progression on systemic carboplatin had a 30% reduction in her target tumor lesions following pembrolizumab treatment with a PD-L1 positive tumor. Treatment was discontinued for grade 3 mucositis after cycle 5. Pembrolizumab may provide some clinical benefit to some patients with vaginal or vulvar SCC and is overall safe to utilize in this population. Future studies are needed to evaluate the efficacy of pembrolizumab in these rare tumor types and to identify predictive biomarkers of response.

Palatine squamous cell carcinoma involving the maxillary sinus in two horses

1992 ◽  
Vol 4 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Fiona Howie ◽  
G. MUNROE ◽  
H. THOMPSON ◽  
D. MURPHY
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Maxillary Sinus ◽  
Squamous Cell

scholarly journals Treatment outcome of maxillary sinus squamous cell carcinoma

Cancer ◽  
2001 ◽  
Vol 92 (6) ◽  
pp. 1495-1503 ◽  
Author(s):  
Tatsuya Hayashi ◽  
Satoshi Nonaka ◽  
Nobuyuki Bandoh ◽  
Yoshifumi Kobayashi ◽  
Masanobu Imada ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Treatment Outcome ◽  
Cell Carcinoma ◽  
Maxillary Sinus ◽  
Squamous Cell

scholarly journals Pattern and Frequency of Skin Malignancies at Laboratory of Pathology Anatomy Dr. Kariadi General Hospital in 2008-2009

Sains Medika ◽  
2015 ◽  
Vol 6 (1) ◽  
pp. 21
Author(s):  
Susilorini Susilorini ◽  
Udadi Sadhana ◽  
Indra Widjaya
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Skin Lesion ◽  
Cell Carcinoma ◽  
General Hospital ◽  
Squamous Cell ◽  
Medical Records ◽  
Secondary Data ◽  
Cross Sectional ◽  
Neoplastic Lesion

Introduction: A periodical database is important including for skin cancer. Periodical registration is needed to acknowledge changes in pattern and frequencies of skin lesion. Objective: The purpose of this study was to describe the pattern and the frequency of skin lesion in RSUD Kariadi.Method: A cross-sectional study was conducted through analysis of the medical records of patients diagnosed skin lesion in the pathology labolatory of RSUD Kariadi between 2008 and 2009. The variables were secondary data including age, gender, specimen area, dan histopathology diagnosis. Data was choosen by consecutive sampling from 381 medical records of skin tissues examined at laboratorium of pathology anatomy of Dr. Kariadi general hospital during 2008-2009.Result: 381 cases were recorded comprising of 246 (65%) neoplastic and 135 (35%) non neoplastic lesion. 120 patients presented with skin cancer, and 126 with benign skin lesion. Most malignancy was observed among female patients (62.5%) on age catagory of 15-39 (65%). The most common lesion was basal cell carcinoma (48.3%) followed by squamous cell carcinoma (33.3%), malignant melanoma (10%), skin appendix carcinoma (2.5%), other malignancies (4.9%).Conclusion: the most common malignancies in Dr. Kariadi general hospital before 2008 was similar to data from 13 laboratory of pathology anatomy in Indonesia, which is squamous cell carcinoma.

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