Cross-linking new technologies application in the treatment of severe corneal pathologies of various etiologies in dogs and cats

The article presents the results of the clinical application of new technology — UV-corneal collagen cross-linking procedure, which we use in the complex therapy of severe corneal pathologies for dogs and cats: septic ulcers complicated by keratomalacia, keratectasias of various origins, endothelial-epithelial corneal dystrophies. The UV cross-linking method is often performed by us as a stage in the preparation of a donor graft during keratoplasty operations in dogs and cats. The effect of the cross-linking treatment procedure is achieved by photopolymerizing collagen fibers of corneal stroma under the combined action of photosensitizer (riboflavin solution) and ultraviolet radiation with a certain wavelength. After cross-linking, it is possible to achieve increase in the biomechanical and biochemical stability of the cornea, to observe dehydration and antimicrobial effects. The article contains information about the stages and results of several methods of UV-corneal collagen cross-linking, which we successfully use in clinical practice in dogs and cats: A-CXL method, PACK-CXL, M-CXL, method of cross-linking modification of donor heterologous graft as a stage in performing keratoplasty surgery to recipient. Based on our clinical results, we can conclude that corneal cross-linking in dogs and cats has a high therapeutic potential and is a promising method for treating severe keratopathies in cases of weak effectiveness of traditional drug therapy regimens.

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Comparison of clinical results of two pharmaceutical products of riboflavin in corneal collagen cross-linking for keratoconus

DARU Journal of Pharmaceutical Sciences ◽

10.1186/2008-2231-22-37 ◽

2014 ◽

Vol 22 (1) ◽

Cited By ~ 1

Author(s):

Hassan Hashemi ◽

Mohammad Amin Seyedian ◽

Mohammad Miraftab ◽

Hooman Bahrmandy ◽

Araz Sabzevari ◽

...

Keyword(s):

Clinical Results ◽

Pharmaceutical Products ◽

Cross Linking ◽

Collagen Cross Linking ◽

Corneal Collagen

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Clinical Results of Corneal Collagen Cross-linking

Corneal Collagen Cross Linking ◽

10.1007/978-3-319-39775-7_6 ◽

2016 ◽

pp. 189-223

Author(s):

Paolo Vinciguerra ◽

Fabrizio I. Camesasca ◽

Leonardo Mastropasqua ◽

Elena Albè ◽

Mario R. Romano ◽

...

Keyword(s):

Clinical Results ◽

Cross Linking ◽

Collagen Cross Linking ◽

Corneal Collagen

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An Update on the Safety and Efficacy of Corneal Collagen Cross-Linking in Pediatric Keratoconus

BioMed Research International ◽

10.1155/2015/257927 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 10

Author(s):

Hala El Rami ◽

Elias Chelala ◽

Ali Dirani ◽

Ali Fadlallah ◽

Henry Fakhoury ◽

...

Keyword(s):

Corneal Stroma ◽

Invasive Procedure ◽

Cross Linking ◽

Covalent Bonds ◽

Safety And Efficacy ◽

Fast Progression ◽

Collagen Cross Linking ◽

Corneal Collagen

Keratoconus is a degenerative disease that affects adolescents and young adults and presents with variable thinning and conical deformation of the corneal apex. The resultant irregular astigmatism can progress to levels that can significantly affect everyday activities and overall quality of life. Therefore, stopping the progression of the disease is an essential part in managing patients with keratoconus. Corneal collagen cross-linking is a minimally invasive procedure that stiffens the anterior corneal stroma by creating strong covalent bonds between collagen fibrils. Over the past decade, many studies have proved its safety and efficacy in halting keratoconus progression in adults. This review of the literature highlights the growing trend towards using this treatment in pediatric keratoconic patients. In children, keratoconus tends to be more severe and fast progression is often encountered requiring closer follow-up intervals. Standard cross-linking shows comparable results in children with a good safety-efficacy profile during follow-up periods of up to three years. Further research is needed to standardize and evaluate transepithelial and accelerated cross-linking protocols as these could be of tremendous help in a population where cooperation and compliance are major issues.

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Rapid spontaneous resolution of corneal hydrops in post-CXL keratitis

BMJ Case Reports ◽

10.1136/bcr-2021-246141 ◽

2021 ◽

Vol 14 (11) ◽

pp. e246141

Author(s):

Toshit Varshney ◽

Siddhi Goel ◽

Rahul Kumar Bafna ◽

Namrata Sharma

Keyword(s):

Optical Coherence Tomography ◽

Anterior Segment ◽

Corneal Stroma ◽

Spontaneous Resolution ◽

Cross Linking ◽

Normal Functioning ◽

Topical Antibiotics ◽

Corneal Hydrops ◽

Collagen Cross Linking ◽

Corneal Collagen

An 11-year-old boy presented with right eye post-Corneal Collagen Cross-Linking (CXL) keratitis, which was complicated by acute corneal hydrops (CH). Keratitis was managed by topical antibiotics, and CH was managed conservatively. Cornea was monitored with serial anterior segment optical coherence tomography (ASOCT) scans. Spontaneous resolution of CH usually takes 8–12 weeks, but in this case it completely resolved in 3 weeks. Rapid resolution of CH after post-CXL keratitis could be attributed to a thinner cornea, increased interlamellar cohesive strength between collagen fibrils of corneal stroma coupled with normal functioning endothelial pump.

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Corneal Collagen Cross-linking for Keratoconus

European Ophthalmic Review ◽

10.17925/eor.2015.09.02.115 ◽

2015 ◽

Vol 09 (02) ◽

pp. 115

Author(s):

Vito Romano ◽

◽

...

Keyword(s):

Corneal Stroma ◽

Cross Linking ◽

Vitamin B2 ◽

Ultraviolet A ◽

Single Application ◽

Collagen Fibres ◽

Successful Technique ◽

Collagen Cross Linking ◽

Corneal Collagen

Corneal collagen cross-linking (CXL) is a successful technique used to slow the progression of corneal ectatic disease, mainly keratoconus. It is able to achieve this aim with a single application of vitamin B2 (riboflavin) and ultraviolet-A light to the corneal stroma where it results in crosslinks to form between the collagen fibres, resulting in corneal stiffening. We describe the different protocols, results and complications reported.

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