Rapid spontaneous resolution of corneal hydrops in post-CXL keratitis

2021 ◽  
Vol 14 (11) ◽  
pp. e246141
Author(s):  
Toshit Varshney ◽  
Siddhi Goel ◽  
Rahul Kumar Bafna ◽  
Namrata Sharma
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Segment ◽  
Corneal Stroma ◽  
Spontaneous Resolution ◽  
Cross Linking ◽  
Normal Functioning ◽  
Topical Antibiotics ◽  
Corneal Hydrops ◽  
Collagen Cross Linking ◽  
Corneal Collagen

An 11-year-old boy presented with right eye post-Corneal Collagen Cross-Linking (CXL) keratitis, which was complicated by acute corneal hydrops (CH). Keratitis was managed by topical antibiotics, and CH was managed conservatively. Cornea was monitored with serial anterior segment optical coherence tomography (ASOCT) scans. Spontaneous resolution of CH usually takes 8–12 weeks, but in this case it completely resolved in 3 weeks. Rapid resolution of CH after post-CXL keratitis could be attributed to a thinner cornea, increased interlamellar cohesive strength between collagen fibrils of corneal stroma coupled with normal functioning endothelial pump.

Visibility and Depth of the Stromal Demarcation Line After Corneal Collagen Cross-Linking Using Anterior Segment Optical Coherence Tomography

Cornea ◽  
2018 ◽  
Vol 37 (5) ◽  
pp. 567-573 ◽  
Author(s):  
Louis Lhuillier ◽  
Cedric Ghetemme ◽  
Mathilde Boiché ◽  
Rekia Yahia ◽  
Naila Houmad ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Segment ◽  
Cross Linking ◽  
Optical Coherence ◽  
Demarcation Line ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Correlation of the Corneal Collagen Cross-Linking Demarcation Line Using Confocal Microscopy and Anterior Segment Optical Coherence Tomography in Keratoconic Patients

2014 ◽  
Vol 157 (1) ◽  
pp. 110-115.e1 ◽  
Author(s):  
George D. Kymionis ◽  
Michael A. Grentzelos ◽  
Argyro D. Plaka ◽  
Konstantinos I. Tsoulnaras ◽  
Vasilios F. Diakonis ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Anterior Segment ◽  
Cross Linking ◽  
Optical Coherence ◽  
Demarcation Line ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Corneal Stromal Demarcation Line Determined With Anterior Segment Optical Coherence Tomography Following a Very High Intensity Corneal Collagen Cross-Linking Protocol

Cornea ◽  
2015 ◽  
Vol 34 (6) ◽  
pp. 664-667 ◽  
Author(s):  
George D. Kymionis ◽  
Konstantinos I. Tsoulnaras ◽  
Dimitrios A. Liakopoulos ◽  
Michael A. Grentzelos ◽  
Theodoros A. Paraskevopoulos ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Intensity ◽  
Anterior Segment ◽  
Cross Linking ◽  
Optical Coherence ◽  
Demarcation Line ◽  
Very High ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Evaluation of the Corneal Collagen Cross-Linking Demarcation Line Profile Using Anterior Segment Optical Coherence Tomography

Cornea ◽  
2013 ◽  
Vol 32 (7) ◽  
pp. 907-910 ◽  
Author(s):  
George D. Kymionis ◽  
Michael A. Grentzelos ◽  
Argyro D. Plaka ◽  
Nela Stojanovic ◽  
Konstantinos I. Tsoulnaras ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Line Profile ◽  
Anterior Segment ◽  
Cross Linking ◽  
Optical Coherence ◽  
Demarcation Line ◽  
Collagen Cross Linking ◽  
Corneal Collagen

scholarly journals Evaluation of Demarcation Line after Epithelium-Off Iontophoresis Corneal Collagen Cross-Linking for Progressive Keratoconus

2021 ◽  
Vol 10 (15) ◽  
pp. 3295
Author(s):  
Francesco D’Oria ◽  
Pasquale Puzo ◽  
Cosimo Incandela ◽  
Alessandra Sborgia ◽  
Samuele Gigliola ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Segment ◽  
Cross Linking ◽  
Optical Coherence ◽  
Single Center ◽  
Demarcation Line ◽  
Single Center Study ◽  
Collagen Cross Linking ◽  
Center Study ◽  
Corneal Collagen

The aim of the study was to visualize and evaluate the characteristics and depth of the demarcation line with anterior segment optical coherence tomography (AS-OCT) after epithelium-off iontophoresis corneal collagen cross-linking (epi-off I-CXL). In this prospective, consecutive, single center study 18 eyes of 18 patients with keratoconus were involved. One month after epi-off I-CXL, all the patients underwent an AS-OCT scan to search for a demarcation line and its characteristics. The corneal stromal demarcation line was identified in all the eyes. Mean depth of the corneal stromal demarcation line was 261.8 ± 46.7 μm (range: 184 to 362 μm), at 56.7 ± 12% corneal depth. In conclusion, epi-off I-CXL determines a demarcation line that can be visualized with AS-OCT, which seems clearly distinguishable and similar to that created in standard CXL.

scholarly journals Iontophoresis-Assisted Corneal Collagen Cross-Linking with Epithelial Debridement: Preliminary Results

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Paolo Vinciguerra ◽  
Vito Romano ◽  
Pietro Rosetta ◽  
Emanuela F. Legrottaglie ◽  
Magdalena Kubrak-Kisza ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Anterior Segment ◽  
Cross Linking ◽  
Prospective Clinical Study ◽  
Positive Trend ◽  
Cell Counts ◽  
Early Results ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Purpose. To report the early outcomes of iontophoresis-assisted corneal collagen cross-linking procedure with epithelial debridement (I-SCXL).Methods. Twenty eyes of twenty patients with progressive keratoconus were included in this prospective clinical study. Best spectacle corrected visual acuity (BSCVA), sphere and cylinder refraction, corneal topography, Scheimpflug tomography, aberrometry, anterior segment optical coherence tomography (AS-OCT), and endothelial cell count were assessed at baseline and at 1, 3, and 6 months of follow-up. The parameters considered to establish keratoconus progression were always proven with differential maps as change in curvature in the cone area of at least 1 diopter obtained with an instantaneous map.Results. Functional parameters showed a significant improvement (p<0.05) of BSCVA after 3 and 6 months of follow-up. Morphological parameters indicated stabilization of the corneal ectasia during the follow-up; however, a positive trend was noted with a mean flattening of 1.73 D. Minimum pachymetry values showed thinning that remained constant after the treatment. The demarcation line was clearly visible in all patients, reaching a depth of308.2±37.74 μm. None of the patients had continuous progression of keratoconus or had to repeat cross-linking procedures. Endothelial cell counts did not change significantly (p>0.05).Conclusion. The early results indicate that the I-SCXL may be able to reduce the treatment time and improve the riboflavin diffusion.

scholarly journals Cross-linking new technologies application in the treatment of severe corneal pathologies of various etiologies in dogs and cats

2021 ◽  
Vol 2021 (3) ◽  
pp. 14-24
Author(s):  
Ul'yana Lukashina ◽  
Yuliya Artyushina
Keyword(s):  
New Technologies ◽  
Therapeutic Potential ◽  
New Technology ◽  
Corneal Stroma ◽  
Clinical Results ◽  
Cross Linking ◽  
Traditional Drug ◽  
Donor Graft ◽  
Collagen Cross Linking ◽  
Corneal Collagen

The article presents the results of the clinical application of new technology — UV-corneal collagen cross-linking procedure, which we use in the complex therapy of severe corneal pathologies for dogs and cats: septic ulcers complicated by keratomalacia, keratectasias of various origins, endothelial-epithelial corneal dystrophies. The UV cross-linking method is often performed by us as a stage in the preparation of a donor graft during keratoplasty operations in dogs and cats. The effect of the cross-linking treatment procedure is achieved by photopolymerizing collagen fibers of corneal stroma under the combined action of photosensitizer (riboflavin solution) and ultraviolet radiation with a certain wavelength. After cross-linking, it is possible to achieve increase in the biomechanical and biochemical stability of the cornea, to observe dehydration and antimicrobial effects. The article contains information about the stages and results of several methods of UV-corneal collagen cross-linking, which we successfully use in clinical practice in dogs and cats: A-CXL method, PACK-CXL, M-CXL, method of cross-linking modification of donor heterologous graft as a stage in performing keratoplasty surgery to recipient. Based on our clinical results, we can conclude that corneal cross-linking in dogs and cats has a high therapeutic potential and is a promising method for treating severe keratopathies in cases of weak effectiveness of traditional drug therapy regimens.

scholarly journals Acute corneal hydrops 3 years after Intra-corneal ring segments and corneal collagen Cross-linking

2016 ◽  
Vol 23 (1) ◽  
pp. 156 ◽  
Author(s):  
Elias Jarade ◽  
Rafic Antonios ◽  
Ali Dirani ◽  
Ali Fadlallah ◽  
Elias Chelala ◽  
...  
Keyword(s):  
Cross Linking ◽  
Corneal Hydrops ◽  
Collagen Cross Linking ◽  
Corneal Collagen
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