scholarly journals Technetium and rhenium schiff base complexes for nuclear medicine

2019 ◽  
Author(s):  
◽  
Jakob Edwin Baumeister
Keyword(s):  
Nuclear Medicine ◽  
Schiff Base ◽  
Reaction Times ◽  
Mixed Ligand ◽  
Schiff Base Complexes ◽  
Microwave Assisted Synthesis ◽  
One Pot ◽  
Diverse Range ◽  
Microwave Assisted ◽  
Potential Applications

This dissertation investigates the synthesis of rhenium and technetium Schiff base complexes for potential applications in nuclear medicine. In Chapter 2, a series of mixed ligand Re(III) complexes of the form trans-[Re(PR3)2(tmf2en)]+ were prepared by microwave assisted synthesis. A two-step (one-pot) procedure was utilized. In the first step, the Re(V) precursor (nBu4N)[ReOCl4] is reacted with the Schiff base ligand forming trans-[ReOCl(tmf2en) in situ. In the second step, a tertiary phosphine ligand is added yielding the reduced trans-[Re(PR3)2(tmf2en)][superscript +] species. The preparation of these trans-[Re(PR3)2(tmf2en)][superscript +] complexes by microwave assisted synthesis resulted in higher reaction yields and shorter reaction times compared to syntheses of similar Re(III) Schiff base complexes. The general methodology proved to be useful for the synthesis of mixed ligand Re(III) complexes with a diverse range of Schiff base ligands and phosphines.

scholarly journals One-Pot Microwave-Assisted Synthesis of Water-Soluble Pyran-2,4,5-triol Glucose Amine Schiff Base Derivative: XRD/HSA Interactions, Crystal Structure, Spectral, Thermal and a DFT/TD-DFT

Crystals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 117
Author(s):  
Yousef Hijji ◽  
Rajeesha Rajan ◽  
Hamdi Ben Yahia ◽  
Said Mansour ◽  
Abdelkader Zarrouk ◽  
...  
Keyword(s):  
Schiff Base ◽  
Molecular Orbital ◽  
Density Functional ◽  
Condensation Reaction ◽  
3D Structure ◽  
Water Soluble ◽  
Microwave Assisted Synthesis ◽  
One Pot ◽  
Microwave Assisted ◽  
Td Dft

The(3R,4R,6R)-3-(((E)-2-hydroxybenzylidene)amino)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,4,5-triol water-soluble Glucose amine Schiff base (GASB-1) product was made available by condensation of 2-hydroxybenzaldehyde with (3R,6R)-3-amino-6-(hydroxymethyl)-tetra-hydro-2H-pyran-2,4,5-triol under mono-mode microwave heating. A one-pot 5-minute microwave-assisted reaction was required to complete the condensation reaction with 90% yield and without having byproducts. The 3D structure of GASB-1 was solved from single crystal X-ray diffraction data and computed by DFT/6-311G(d,p). The Hirshfeld surface analysis (HSA), molecular electronic potential (MEP), Mulliken atomic charge (MAC), and natural population analysis (NPA) were performed. The IR and UV-Vis spectra were matched to their density functional theory (DFT) relatives and the thermal behavior was resolved in an open-room condition via thermogravimetry/Derivative thermogravimetry (TG/DTG) and differential scanning calorimetry (DSC). The highest occupied molecular orbital/lowest unoccupied molecular orbital (HOMO/LUMO), density of state (DOS), and time-dependence TD-DFT computations were correlated to the experimental electron transfer in water and acrylonitrile solvents.

Microwave Assisted Synthesis and Characterisation of Trinuclear Zinc(II) Schiff Base Complexes Derived from m-phenylenediamine and Salicylaldehyde

2020 ◽  
Vol 14 (1) ◽  
pp. 29
Author(s):  
Karimah Kassim ◽  
Muhamad Azwan Hamali
Keyword(s):  
Schiff Base ◽  
1H Nmr ◽  
Metal Ion ◽  
Synthesis Method ◽  
Mononuclear Complex ◽  
Schiff Base Complexes ◽  
Trinuclear Complex ◽  
Microwave Assisted Synthesis ◽  
Infrared Band ◽  
Microwave Assisted

A series of Schiff base ligand, SALMPD, and its mono- and trinuclear Zn(II) metal complexes were synthesised from m-phenylenediamine and salicylaldehyde in alcoholic solution. The synthesis of ligand and mononuclear complex were synthesised using conventional condensation method, while the trinuclear complex was done using microwave-assisted synthesis method. The structure of each compound was elucidated by elemental analysis, infrared and 1H NMR spectroscopy. The infrared spectrum of SALMPD shows a strong azomethine (C=N) band at 1621.62cm-1, indicates the formation of the ligand. Upon complexation of the mononuclear complex, the C=N infrared band shifted and the disappearing of the phenolic hydrogen signal in 1H NMR suggesting the chelation between Zinc(II) metal ion and ligand took place when azomethine and phenolic hydrogen deprotonated.  The trinuclear complex, Zn3(SALMPD) obtained was consist of two moieties of mononuclear Zn(SALMPD), which act as ligands that chelating to the third Zn(II) metal ion through oxygen atom due to the shifting of M-O infrared band from 575.12-540.53cm-1, which serves as a coordination site for the metal ion.

Microwave Assisted Synthesis and Characterisation of Trinuclear Zinc(II) Schiff Base Complexes Derived from m-phenylenediamine and Salicylaldehyde

2017 ◽  
Vol 14 (1) ◽  
pp. 29
Author(s):  
Karimah Kassim ◽  
Muhammad Azwan Hamali
Keyword(s):  
Schiff Base ◽  
1H Nmr ◽  
Metal Ion ◽  
Synthesis Method ◽  
Mononuclear Complex ◽  
Schiff Base Complexes ◽  
Trinuclear Complex ◽  
Microwave Assisted Synthesis ◽  
Infrared Band ◽  
Microwave Assisted

A series of Schiff base ligand, SALMPD, and its mono- and trinuclear Zn(II) metal complexes were synthesised from m-phenylenediamine and salicylaldehyde in alcoholic solution. The synthesis of ligand and mononuclear complex were synthesised using conventional condensation method, while the trinuclear complex was done using microwave-assisted synthesis method. The structure of each compound was elucidated by elemental analysis, infrared and 1H NMR spectroscopy. The infrared spectrum of SALMPD shows a strong azomethine (C=N) band at 1621.62cm-1, indicates the formation of the ligand. Upon complexation of the mononuclear complex, the C=N infrared band shifted and the disappearing of the phenolic hydrogen signal in 1H NMR suggesting the chelation between Zinc(II) metal ion and ligand took place when azomethine and phenolic hydrogen deprotonated. The trinuclear complex, Zn3(SALMPD) obtained was consist of two moieties of mononuclear Zn(SALMPD), which act as ligands that chelating to the third Zn(II) metal ion through oxygen atom due to the shifting of M-O infrared band from 575.12-540.53cm-1, which serves as a coordination site for the metal ion.

Microwave-assisted synthesis of porphyrins and metalloporphyrins: a rapid and efficient synthetic method

2007 ◽  
Vol 11 (02) ◽  
pp. 77-84 ◽  
Author(s):  
Bruno F. O. Nascimento ◽  
Marta Pineiro ◽  
António M. d'A. Rocha Gonsalves ◽  
Manuela Ramos Silva ◽  
Ana Matos Beja ◽  
...  
Keyword(s):  
Transition Metals ◽  
Reaction Times ◽  
Microwave Assisted Synthesis ◽  
Synthetic Method ◽  
One Pot ◽  
Microwave Assisted ◽  
Experimental Protocols ◽  
Porphyrin Core ◽  
High Yields

The effective 'one-pot' microwave-assisted synthesis of several substituted 5,10,15,20-tetraarylporphyrins is reported. The microwave-assisted insertion of five different transition metals into the 5,10,15,20-tetraphenylporphyrin, 5,10,15,20-tetrakis(4-chlorophenyl)porphyrin and 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin core was also achieved with high yields. In addition to their simplicity, both these straightforward, experimental protocols were also characterized by extremely short reaction times and quite small quantities of solvents employed.

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