scholarly journals Proportion and Factors that Associate with Incidence of Hepatotoxicity in Rheumatoid Arthritis Patients Treated with Methotrexate in RSCM Year 2013−2015

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Rahma Anindya Prathitasari ◽  
Harry Isbagio
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Autoimmune Disease ◽  
Disease Progression ◽  
Alanine Aminotransferase ◽  
Side Effect ◽  
Normal Limit ◽  
Keywords Rheumatoid Arthritis ◽  
Chronic Autoimmune Disease

Background Rheumatoid arhtirtis (RA) is a chronic autoimmune disease that mainly attacks joints. It may causes joint deformities which leads to lower quality of life of RA patients. RA is treated with metothrexate (MTX) which inhibiting disease progression. MTX is known for its hepatotoxicity side effect, which is described by an elevation of aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) beyond the upper normal limit. Factors that may enhance hepatotoxicity are gender, age, cummulative dose of MTX, and duration therapy of MTX. Prevalence of hepatotoxicity caused by MTX therapy in RA patients in Indonesia is still unknown. The objective of this research is to know the proportion of hepatotoxicity and its associations with the factors that may enhance hepatotoxicity caused by MTX therapy in RA patients in RSCM.Method Data about gender, age, cummulative dose and duration therapy of MTX are obtained from 115 RA patients' medical records.Result Proportion of hepatotoxicity in RA patients treated with MTX in RSCM is 42.60%. Gender, age, cummulative dose and duration therapy of MTX do not significantly enhance hepatotoxicity (p>0.05).Conclusion In conclusion gender, age, cummulative dose and duration therapy of MTX do not have association with hepatotoxicity in RA patients treated with MTX. Keywords: Rheumatoid Arthritis, Methotrexate, Hepatotoxicity

scholarly journals Proportion and Factors that Associate with Incidence of Hepatotoxicity in Rheumatoid Arthritis Patients Treated with Methotrexate in RSCM Year 2013−2015

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Rahma Anindya Prathitasari ◽  
Harry Isbagio
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Autoimmune Disease ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Side Effect ◽  
Normal Limit ◽  
Keywords Rheumatoid Arthritis ◽  
Chronic Autoimmune Disease

Background Rheumatoid arhtirtis (RA) is a chronic autoimmune disease that mainly attacks joints. It may causes joint deformities which leads to lower quality of life of RA patients. RA is treated with metothrexate (MTX) which inhibiting disease progression. MTX is known for its hepatotoxicity side effect, which is described by an elevation of aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) beyond the upper normal limit. Factors that may enhance hepatotoxicity are gender, age, cummulative dose of MTX, and duration therapy of MTX. Prevalence of hepatotoxicity caused by MTX therapy in RA patients in Indonesia is still unknown. The objective of this research is to know the proportion of hepatotoxicity and its associations with the factors that may enhance hepatotoxicity caused by MTX therapy in RA patients in RSCM.Method Data about gender, age, cummulative dose and duration therapy of MTX are obtained from 115 RA patients' medical records.Result Proportion of hepatotoxicity in RA patients treated with MTX in RSCM is 42.60%. Gender, age, cummulative dose and duration therapy of MTX do not significantly enhance hepatotoxicity (p>0.05).Conclusion In conclusion gender, age, cummulative dose and duration therapy of MTX do not have association with hepatotoxicity in RA patients treated with MTX. Keywords: Rheumatoid Arthritis, Methotrexate, Hepatotoxicity

Impact of disease progression on health status, quality of life and costs in rheumatoid arthritis in Hungary

2008 ◽  
Vol 149 (16) ◽  
pp. 733-741 ◽  
Author(s):  
Márta Péntek ◽  
Zoltán Szekanecz ◽  
László Czirják ◽  
Gyula Poór ◽  
Bernadette Rojkovich ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Health Status ◽  
Disease Progression

A rheumatoid arthritis (RA) krónikus, progresszív, szimmetrikus sokízületi gyulladás. A betegek hosszú távú gondozásához és a költséghatékonysági modellekhez alapvető ismerni és standardizáltan mérni a betegség lefolyását és annak következményeit. Célkitűzés: A betegségprogresszió és az egészségi állapot, életminőség és költségek kapcsolatainak vizsgálata magyarországi RA-s betegeken. Módszer: 2004. április–augusztus között keresztmetszeti kérdőíves vizsgálatot végeztek RA-s betegek bevonásával hat fekvőbeteg-osztályos háttérrel rendelkező járóbeteg-szakambulancián. Standardizált kérdőívekkel vizsgálták a betegség progresszióját kifejező funkcionális állapotot (HAQ), az egészségi állapotot (EQ-5D), a betegségspecifikus életminőséget (RAQoL), felmérték a betegségaktivitást (DAS) és a betegséggel összefüggő költségeket, elemezték e paraméterek kapcsolatát. Eredmények: 255 beteg adatait elemezték [átlagos életkor: 55,5 ± 12,3 év; a betegség fennállása: 9,0 ± 9,3 év; HAQ: 1,38 ± 0,76; EQ-5D: 0,46 ± 0,33; RAQoL: 16,2 ± 8,1; DAS: 5,09 ± 1,42; költség: 1 043 163 (± 844 750) Ft/beteg/év]. Szignifikáns korrelációt találtak az összes esetben ( p < 0,01), függvénykapcsolat volt kimutatható: EQ-5D index = 1,014–0,25 × HAQ–0,041 × DAS és HAQ = 0,314 + 0,065 × RAQoL. Betegségsúlyossági csoportonként (0,5 HAQ-léptékkel) vizsgálva, az egészségi állapot átlaga rosszabbodott (EQ-5D: 0,784; 0,576; 0,504; 0,367; 0,211; 0,022), és az átlagos költség emelkedett (628 280; 888 187; 953 759; 1 291 218; 1 346 112; 1 371 674 Ft/beteg/év) a betegség előrehaladásával. Minimális klinikailag szignifikáns funkciócsökkenés (0,25 HAQ-változás) 0,0705 EQ-5D-csökkenésnek és 1,884 RAQoL-emelkedésnek felelt meg, nem súlyosan aktív (DAS < 5,1) esetekben kisebb a változás (EQ-5D: 0,05725). Következtetések: A betegségprogresszió és az általános egészségi állapot, életminőség és a költségek kapcsolata nem tér el jelentősen a nemzetközi eredményektől. A betegségköltségek nagysága azonban jelentősen kisebb Magyarországon, mint a fejlett országokban. A vizsgálat adatokkal szolgál a hazai egészség-gazdaságtani elemzésekhez.

scholarly journals Oral lichen planus: a novel staging and algorithmic approach and all that is essential to know

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 206
Author(s):  
Eran Shavit ◽  
Klieb Hagen ◽  
Neil Shear
Keyword(s):  
Quality Of Life ◽  
Autoimmune Disease ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Staging System ◽  
Oral Lesions ◽  
Algorithmic Approach ◽  
Chronic Autoimmune Disease ◽  
Oral Lichen

Lichen planus (LP) is a chronic autoimmune disease. Oral lesions may occur in isolation or in combination with other affected muco-cutaneous sites. Oral LP (OLP) may present as one of the various manifestations of LP or may present as a disease sui generis with a broad range of severity. Despite this disease targeting the oral mucosa, its great impact on quality of life is underrated. In this article, we provide an updated review of the pathophysiology and epidemiology of OLP and offer guidance for its diagnosis and management. We also propose an algorithmic approach to the clinical forms of OLP and a novel staging system to facilitate management decisions.

Psychosomatic Features, Compliance and Complementary Therapies in Rheumatoid Arthritis

2020 ◽  
Vol 16 (3) ◽  
pp. 215-223
Author(s):  
Rostislav A. Grekhov ◽  
Galina P. Suleimanova ◽  
Andrei S. Trofimenko ◽  
Liudmila N. Shilova
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Interpersonal Relationships ◽  
Behavioral Therapy ◽  
Current Data ◽  
Psychotherapeutic Interventions ◽  
And Coping ◽  
Regulation Of Emotion ◽  
The Impact

This review highlights the issue of psychosomatic conditions in rheumatoid arthritis, paying special attention to new researches and trends in this field. Emerging concepts in all the major parts of the problem are covered consecutively, from the impact of chronic musculoskeletal pain on the emotional state to disease influence over quality of life, socio-psychological, and interpersonal relationships. Chronic pain is closely related to emotional responses and coping ability, with a pronounced positive effect of psychotherapeutic interventions, family and social support on it. Psychosexual disorders, anxiety, depression also commonly coexist with rheumatoid arthritis, leading to further decrease in quality of life, low compliance, and high suicide risk. Influence of psychosomatic conditions on the overall treatment effect is usually underestimated by rheumatologists and general practitioners. Psychosomatic considerations are of great importance for up-to-date management of rheumatoid arthritis, as they strongly influence the quality of life, compliance, and thereby disease outcomes. Two major approaches of psychological rehabilitation exist, both coping with pain through the regulation of emotion and psychotherapeutic intervention, which not only helps patients in coping with the disease, but also aimed at improving the overall adaptation of the patient. It includes techniques of relaxation, cognitive-behavioral therapy, and biofeedback therapy. Current data about the efficacy of the additional correcting therapies for patients with rheumatoid arthritis, both emerging and common ones, are discussed in the review.

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