Clinical and hematological characteristics  of patients with Non-Hodgkin’s lymphomas who were treated  at the National Military Medical Clinical Center  «Main Military Clinical Hospital» from 2015 to 2019.

Nosocomial infections pose a serious burden for hospitals, patients, and the entire society. The aim of the study was to assess the microbiological cleanliness of the hospital environment through quantitative and qualitative analysis of microbiological contamination of air and surfaces in inpatient treatment facilities, based on the example of a large clinical hospital in Poland. Data were collected between 2012 and 2018 in premises of a large teaching hospital in Gdansk using the sedimentation method and the impact method using the Aerideal apparatus (Biomerieux). In the analyzed clinical center, the microbiological cleanliness tests in most of the hospital rooms in the analyzed period showed an acceptable number of saprophytic microorganisms. Of all the tested samples, 1159 (21.8%) were positive, indicating the presence of microorganisms in the tested sample. Species potentially pathogenic for hospital patients were identified, constituting 20.8% of all positive samples (4.6% of all samples). Significantly higher proportion of microorganisms potentially dangerous to patients were isolated from sanitary facilities. Due to the potentially pathogenic microorganisms detected in the tested samples, the authors suggest that in the analyzed hospital, the areas requiring a specific level of microbiological purity should be designated and described, with [specifically] defined cleaning and disinfection protocols.

Download Full-text

Experience of the skin basal cell carcinoma treatment at the Clinic of maxillofacial surgery and dentistry of National Military Medical Clinical Center «Main Military Clinical Hospital»

Current aspects of military medicine. Сучасні аспекти військової медицини ◽

10.32751/2310-4910-2020-27-41 ◽

2020 ◽

Vol 27 (2) ◽

pp. 186-193

Author(s):

І. В. Федірко ◽

П. А. Шмідт ◽

О. М. Нестеренко

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Maxillofacial Surgery ◽

Clinical Hospital ◽

Clinical Center

Download Full-text

Infusion intravenous IgG replacement therapy for hypogammaglobulinemia after anti-CD20 monoclonal antibodies at patients with non-hodgkin’s malignant lymphomas

Infusion & Chemotherapy ◽

10.32902/2663-0338-2020-3.1-55 ◽

2020 ◽

pp. 66-67

Author(s):

Ya.B. Savchenko ◽

S.A. Guseva

Keyword(s):

Replacement Therapy ◽

Statistical Processing ◽

Infectious Complications ◽

Excess Morbidity ◽

Clinical Center ◽

Before And After ◽

Anti Cd20 ◽

Microsoft Office ◽

Hodgkin's Lymphomas ◽

Igg Replacement Therapy

Objective. Determining the risk of infectious complications in patients with non-hodgkin’s lymphomas (NМL) who received anti-CD20 monoclonal therapy and the effectiveness of intravenous immunoglobulin G (IgG) replacement therapy. Materials and methods. A prospective analysis of data of 37 persons with NML who were treated in the hematology clinic of the National Military Medical Clinical Center “Main Military Clinical Hospital” from January to December 2019. Statistical data processing was performed using computer programs Microsoft Office Excel (2007) and statistical processing package Statistica 6.0 using the procedure 2×2 Tables (YI/VI/Phil, McNemar, Fisher Exact) module Nonparametric Statistics, which uses the analysis of a four-cell conjugation table. Results and discussion. The mean age of patients was 56.5±1.4 years; 12 (32.43 %) were female patients. Baseline IgG levels before anti-CD20 monoclonal therapy were not determined in 17 (45.94 %) patients. Hypogammaglobulinemia was detected in 20 (54.05 %) subjects who were tested for IgG levels prior to anti-CD20 therapy. After administration of anti-CD20 monoclonal therapy, hypogammaglobulinemia worsened. There was an increase in severe infections after anti-CD20 therapy (from 9.4 to 40.7 %; p<0,001). An analysis of patient survival within 6 months of starting anti-CD20 monoclonal therapy revealed an increased mortality associated with an increase in age (hazard ratio (HR) 1.05; 95 % confidence interval (CI) 1.00-1.02; p<0.005), male (HR 1.12; 95 % CI 1.01-1.18; p<0.005), severe infectious complications (HR 5.18; 95 % CI 3.16-4,72; p<0.001). Only 10 (27.02 %) patients received IgG replacement therapy after anti-CD20 monoclonal therapy. Among these patients, a higher cumulative dose of immunoglobulin replacement therapy was associated with a reduced risk of serious infectious complications (HR 1.00; 95 % CI 0.98-1.02; p<0.005). Conclusions. Monitoring of IgG levels both before and after rituximab therapy may allow for earlier identification of risk for developing significant infection and identify patients who may benefit from IgG replacement, which may in turn help to avoid excess morbidity and mortality.

Download Full-text

Analysis of medical care for combatants in the setting of outpatient clinic of National Military Medical Clinical Center «Mail Military Clinical Hospital»

Current aspects of military medicine. Сучасні аспекти військової медицини ◽

10.32751/2310-4910-2020-27-01 ◽

2020 ◽

Vol 27 (1) ◽

pp. 3-12

Author(s):

Т. А. Бібік ◽

Д. В. Гужвенко ◽

C. В. Агрепишин

Keyword(s):

Medical Care ◽

Outpatient Clinic ◽

Clinical Hospital ◽

Clinical Center

Download Full-text

ANALYSIS OF SHORTCOMINGS IN MEDICAL CARE PROVIDING TO SERVICEMEN IN THE NATIONAL MILITARY MEDICAL CLINICAL CENTER "MAIN MILITARY CLINICAL HOSPITAL"

International Medical Journal ◽

10.37436/2308-5274-2020-2-15 ◽

2020 ◽

pp. 77-80

Author(s):

O. I. Hrechanyk ◽

R. Ya. Abdullaiev

Keyword(s):

Medical Care ◽

Organizational Support ◽

Medical Records ◽

Treatment Process ◽

Clinical Medicine ◽

Officer Corps ◽

Clinical Hospital ◽

Medical Institutions ◽

Clinical Center ◽

Underlying Diseases

Assessing the quality of medical care, identifying defects in its provision, studying the shortcomings of medical activities are extremely important not only for forensic expertise or law enforcement practice, but also for all clinical medicine. For the purpose of clinical and anatomical analysis as well as the creation of classification of medical errors which most often occur in the conditions of military medical and preventive institution, revealing of their reasons in National military medical clinical center "Main military clinical hospital" (Kyiv) research was carried out in the period 2016− In 2018, the defects in the provision of medical care were analyzed using medical records, protocols of pathological examinations, acts of meetings of the commission for the study of lethal consequences, as well as reviews of medical records. It was established that erroneous actions of the medical doctors occurred during diagnosis, treatment, medical records, as well as in the organizational support of medical activities. In 2016, 32 defects were identified, in 2017 this number was 29, and in 2018 that was 37. Inadequate medical care was usually provided in insufficient quantities and late. The largest number of servicemen by category fell on the officer corps, the smallest one did on army conscripts. It has been proven that defects in class XI (digestive diseases), in class X (respiratory diseases), and also in class VI (diseases of the nervous system) occurred much more often. The main shortcomings in the organization of medical care for servicemen were unrecognized underlying diseases and errors in maintaining medical records. The causes of recognized defects are objective difficulties of diagnosis, shortcomings in the organization of the treatment process and the atypical course of the disease. The identified shortcomings in the provision of medical care to servicemen and their internal/external reasons should be taken into account when organizing a more effective treatment process in medical institutions of our country. Key words: National Military Medical Clinical Center "Main Military Clinical Hospital", shortcomings in medical care provision, servicemen.

Download Full-text

Proteasome inhibitors as therapeutics

Essays in Biochemistry ◽

10.1042/bse0410205 ◽

2005 ◽

Vol 41 ◽

pp. 205-218

Author(s):

Constantine S. Mitsiades ◽

Nicholas Mitsiades ◽

Teru Hideshima ◽

Paul G. Richardson ◽

Kenneth C. Anderson

Keyword(s):

Multiple Myeloma ◽

Drug Class ◽

Proteasome Inhibitors ◽

Cell Cycle Regulators ◽

Current State ◽

Intracellular Mechanism ◽

Ubiquitin Proteasome ◽

Proteasome Pathway ◽

Hodgkin's Lymphomas ◽

Clinical Research Data

The ubiquitin–proteasome pathway is a principle intracellular mechanism for controlled protein degradation and has recently emerged as an attractive target for anticancer therapies, because of the pleiotropic cell-cycle regulators and modulators of apoptosis that are controlled by proteasome function. In this chapter, we review the current state of the field of proteasome inhibitors and their prototypic member, bortezomib, which was recently approved by the U.S. Food and Drug Administration for the treatment of advanced multiple myeloma. Particular emphasis is placed on the pre-clinical research data that became the basis for eventual clinical applications of proteasome inhibitors, an overview of the clinical development of this exciting drug class in multiple myeloma, and a appraisal of possible uses in other haematological malignancies, such non-Hodgkin's lymphomas.

Download Full-text