Spindle Cell Carcinoma of the Breast: A Case Report Representing Diagnostics, Therapeutics, Intervention, and Outcome

Background: Spindle cell carcinoma (SpCC) is an unusual form of squamous cell carcinoma (SCC) and can sometimes present in the breast. Owing to the rarity of breast SpCC, few case studies are available nowadays and proper evidence is scarce. Case presentation: We herein report a 60-year-old female patient, who was referred to the surgery services after presenting with a right breast ulcerated mass. On physical examination, a 7x7 cm mass was found along with a 3 cm ulcer on the top of it. Both mammography and ultrasound showed a dense mass, and tru-cut and skin punch biopsies confirmed neoplastic spindle cells within the lesion. The patient underwent a right total mastectomy with sentinel lymph node biopsies with no further chemotherapy or radiotherapy. Conclusion: Owing to the heterogeneity of SpCC, there is no exact treatment protocol for this type of cancer, and mastectomy or conservative surgery can be performed in certain groups of patients depending on tumor size, stage, and lymph node involvement. Fortunately, promising medical and biological therapies might be of use in the near future.

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Thoracic Lymph Node Involvement in Adenocarcinoma of the Esophagogastric Junction and Lower Esophageal Squamous Cell Carcinoma Relative to the Location of the Proximal End of the Tumor

Annals of Surgical Oncology ◽

10.1245/s10434-014-3548-2 ◽

2014 ◽

Vol 21 (5) ◽

pp. 1596-1601 ◽

Cited By ~ 4

Author(s):

Shinji Mine ◽

Takeshi Sano ◽

Naoki Hiki ◽

Kazuhiko Yamada ◽

Toshiyuki Kosuga ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Esophagogastric Junction ◽

Lymph Node Involvement ◽

Thoracic Lymph Node ◽

Node Involvement

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Transitional cell carcinoma of the urinary bladder with regional lymph node involvement treated by cystectomy

Cancer ◽

10.1002/cncr.11370 ◽

2003 ◽

Vol 97 (10) ◽

pp. 2425-2431 ◽

Cited By ~ 56

Author(s):

Igor Frank ◽

John C. Cheville ◽

Michael L. Blute ◽

Christine M. Lohse ◽

Ajay Nehra ◽

...

Keyword(s):

Lymph Node ◽

Urinary Bladder ◽

Transitional Cell Carcinoma ◽

Cell Carcinoma ◽

Regional Lymph Node ◽

Transitional Cell ◽

Lymph Node Involvement ◽

Regional Lymph Node Involvement ◽

Node Involvement

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Renal Angiomyolipoma: Report of three cases with Regional Lymph Node Involvement and/or with Renal Cell Carcinoma

Tumori Journal ◽

10.1177/030089169508100619 ◽

1995 ◽

Vol 81 (6) ◽

pp. 469-474 ◽

Cited By ~ 9

Author(s):

György Csanaky ◽

Zoltán Szereday ◽

Tamás Magyarlaki ◽

Gábor Méhes ◽

Tamás Herbert ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Lymph Node ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Tuberous Sclerosis ◽

Malignant Transformation ◽

Renal Cell ◽

Dna Ploidy ◽

Lymph Node Involvement ◽

Node Involvement

Aims and background Angiomyolipomas (AMLs) are benign hamartoid tumors which frequently occur in tuberous sclerosis (TS). They may be manifest at different organ sites such as kidneys, lymph nodes, liver and lung and may be associated with renal cell carcinoma (RCC). The nature of multiple organ involvement in AML (metastasis versus multicentric synchronous tumors), the malignant transformation and the relation of AML to RCC have not been sufficiently clarified. Study design Three cases of renal AMLs in patients with tuberous sclerosis associated with lymphangioleiomyomatosis of the paraaortic lymph nodes and/or with RCC are reported. The concise clinical history of the patients as well as the findings of histology, immunohistochemistry and quantitative DNA analysis are presented. Results The multicentric form of AML and coincidence of renal AML and RCC were observed in 2 patients. AML and RCC were found within the same focus in one of the cases. RCCs were either aneuploid or “near diploid”, whereas one of the multicentric AMLs showed a discordant DNA ploidy pattern, namely aneuploidy in the kidney and diploidy in the lymph nodes. Conclusions The presented cases (all of them underwent periaortic lymphadenectomy) suggest that lymph node involvement in renal AML may be more frequent than expected (1-2% of all AMLs) on the basis of the few reported cases. The discordant DNA ploidy (renal versus lymph node lesions) observed in one of the cases with multicentric AML implies synchronous tumor growth at different sites rather than metastatic disease. The intimate coexistance of RCC and AML (RCC revealed by immunohistochemistry within a larger mass of renal AML) may indicate that malignant transformation of an AML should only be accepted, if such a coincidence is unequivocally excluded.

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