scholarly journals The Combination of Prognostic Nutritional Indicator and Serum Carcinoembryonic Antigen is Useful in Predicting Postoperative Recurrence in Stage II Colorectal Cancer

2021 ◽  
Vol 64 (2) ◽  
pp. 176-183
Author(s):  
Chihiro Uejima ◽  
Hiroaki Saito ◽  
Yoichiro Tada ◽  
Akimitsu Tanio ◽  
Yuki Murakami ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Carcinoembryonic Antigen ◽  
Postoperative Recurrence ◽  
Stage Ii ◽  
Serum Carcinoembryonic Antigen ◽  
Stage Ii Colorectal Cancer ◽  
Nutritional Indicator

scholarly journals Association Between Serum Carcinoembryonic Antigen Levels at Different Perioperative Time Points and Colorectal Cancer Outcomes

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhenhui Li ◽  
Dafu Zhang ◽  
Xiaolin Pang ◽  
Shan Yan ◽  
Ming Lei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Sensitivity Analysis ◽  
Carcinoembryonic Antigen ◽  
Cox Regression ◽  
Neoadjuvant Treatment ◽  
Stage Ii ◽  
Optimal Timing ◽  
Primary Analysis ◽  
Serum Carcinoembryonic Antigen ◽  
Serum Cea

BackgroundWhether elevated postoperative serum carcinoembryonic antigen (CEA) levels are prognostic in patients with stage II colorectal cancer (CRC) remains controversial.Patients and MethodsPrimary and sensitivity analysis populations were obtained from a retrospective, multicenter longitudinal cohort including consecutive patients without neoadjuvant treatment undergoing curative resection for stage I–III CRC. Serum CEA levels before (CEApre-m1) and within 1 (CEApost-m1), 2–3 (CEApost-m2–3), and 4–6 months (CEApost-m4–6) after surgery were obtained, and their associations with recurrence-free survival (RFS) and overall survival (OS) were assessed using Cox regression. Sensitivity and subgroup analyses were performed.ResultsPrimary and sensitivity analysis populations included 710 [415 men; age, 54.8 (11.6) years] and 1556 patients [941 men; age, 56.2 (11.8) years], respectively. Recurrence hazard ratios (HRs) in the elevated CEApre-m1, CEApost-m1, CEApost-m2–3, and CEApost-m4–6 groups were 1.30 (95% CI: 0.91–1.85), 1.53 (95% CI: 0.89–2.62), 1.88 (95% CI: 1.08–3.28), and 1.15 (95% CI: 0.91–1.85), respectively. The HRs of the elevated CEApre-m1, CEApost-m1, CEApost-m2–3, and CEApost-m4–6 groups for OS were 1.09 (95% CI: 0.60–1.97), 2.78 (95% CI: 1.34–5.79), 2.81 (95% CI: 1.25–6.30), and 3.30 (95% CI: 1.67–.536), respectively. Adjusted multivariate analyses showed that both in the primary and sensitivity analysis populations, elevated CEApost-m2–3, rather than CEApre-m1, CEApost-m1, and CEApost-m4–6, was an independent risk factor for recurrence, but not for OS. The RFS in the elevated and normal CEApost-m2–3 groups differed significantly among patients with stage II disease [n = 266; HR, 2.89; 95% CI, 1.02–8.24 (primary analysis); n = 612; HR, 2.69; 95% CI, 1.34–5.38 (sensitivity analysis)].ConclusionsElevated postoperative CEA levels are prognostic in patients with stage II CRC, with 2–3 months after surgery being the optimal timing for CEA measurement.

Serum carcinoembryonic antigen pre‐operative level in colorectal cancer: revisiting risk stratification

2021 ◽  
Author(s):  
Cristiana Iacuzzo ◽  
Paola Germani ◽  
Marina Troian ◽  
Tommaso Cipolat Mis ◽  
Fabiola Giudici ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Stratification ◽  
Carcinoembryonic Antigen ◽  
Serum Carcinoembryonic Antigen

Late Recurrence of Low-Risk Stage II Colorectal Cancer Shortly After Etanercept

2015 ◽  
Vol 47 (4) ◽  
pp. 506-508 ◽  
Author(s):  
Tony Ibrahim ◽  
Khalil Saleh ◽  
Viviane Track-smayra ◽  
Nelly Ziade ◽  
Dalia Sarraf ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Late Recurrence ◽  
Low Risk ◽  
Stage Ii ◽  
Stage Ii Colorectal Cancer

Gene Expression Profiles as Predictors of Poor Outcomes in Stage II Colorectal Cancer: A Systematic Review and Meta-analysis

2009 ◽  
Vol 8 (4) ◽  
pp. 207-214 ◽  
Author(s):  
An-Ting T. Lu ◽  
Shelley R. Salpeter ◽  
Anthony E. Reeve ◽  
Steven Eschrich ◽  
Patrick G. Johnston ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Systematic Review ◽  
Expression Profiles ◽  
Meta Analysis ◽  
Gene Expression Profiles ◽  
Stage Ii ◽  
Stage Ii Colorectal Cancer ◽  
Poor Outcomes
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