scholarly journals Features of maternal behavior of the Wistar rats in the “open field” test when modeling a stress

2020 ◽  
pp. 17
Keyword(s):  
Open Field ◽  
Field Test ◽  
Maternal Behavior ◽  
Wistar Rats ◽  
Open Field Test

scholarly journals Participation ofGABAAChloride Channels in the Anxiolytic-Like Effects of a Fatty Acid Mixture

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Juan Francisco Rodríguez-Landa ◽  
Rosa Isela García-Ríos ◽  
Jonathan Cueto-Escobedo ◽  
Blandina Bernal-Morales ◽  
Carlos M. Contreras
Keyword(s):  
Open Field ◽  
Field Test ◽  
Chloride Channels ◽  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Open Field Test ◽  
Acid Mixture ◽  
Plus Maze ◽  
Gaba Binding ◽  
Defensive Burying

Human amniotic fluid and a mixture of eight fatty acids (FAT-M) identified in this maternal fluid (C12:0, lauric acid, 0.9 μg%; C14:0, myristic acid, 6.9 μg%; C16:0, palmitic acid, 35.3 μg%; C16:1, palmitoleic acid, 16.4 μg%; C18:0, stearic acid, 8.5 μg%; C18:1cis, oleic acid, 18.4 μg%; C18:1trans, elaidic acid, 3.5 μg%; C18:2, linoleic acid, 10.1 μg%) produce anxiolytic-like effects that are comparable to diazepam in Wistar rats, suggesting the involvement ofγ-aminobutyric acid-A (GABAA) receptors, a possibility not yet explored. Wistar rats were subjected to the defensive burying test, elevated plus maze, and open field test. In different groups, threeGABAAreceptor antagonists were administered 30 min before FAT-M administration, including the competitive GABA binding antagonist bicuculline (1 mg/kg),GABAAbenzodiazepine antagonist flumazenil (5 mg/kg), and noncompetitiveGABAAchloride channel antagonist picrotoxin (1 mg/kg). The FAT-M exerted anxiolytic-like effects in the defensive burying test and elevated plus maze, without affecting locomotor activity in the open field test. TheGABAAantagonists alone did not produce significant changes in the behavioral tests. Picrotoxin but not bicuculline or flumazenil blocked the anxiolytic-like effect of the FAT-M. Based on the specific blocking action of picrotoxin on the effects of the FAT-M, we conclude that the FAT-M exerted its anxiolytic-like effects throughGABAAreceptor chloride channels.

scholarly journals Montanoa frutescensandMontanoa grandifloraExtracts Reduce Anxiety-Like Behavior during the Metestrus-Diestrus Phase of the Ovarian Cycle in Wistar Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Juan Francisco Rodríguez-Landa ◽  
Julio Vicente-Serna ◽  
Luis Alfredo Rodríguez-Blanco ◽  
María de Jesús Rovirosa-Hernández ◽  
Francisco García-Orduña ◽  
...  
Keyword(s):  
Open Field ◽  
Field Test ◽  
Wistar Rats ◽  
Open Field Test ◽  
Ovarian Cycle ◽  
Male Rats ◽  
Cycle Phase ◽  
Medicinal Use ◽  
Plus Maze ◽  
Estrus Phase

In previous studies, the anxiolytic-like effects ofMontanoa tomentosaandMontanoa frutescenswere reported in male rats, but the potential anxiolytic-like effects ofMontanoaplants during the different phases of the ovarian cycle in rats remain to be explored. The anxiolytic-like effects of the aqueous crude extracts ofM. frutescens(25 and 50 mg/kg) andM. grandiflora(25 and 50 mg/kg) in the elevated plus maze were investigated in Wistar rats during the estrous cycle and compared with 2 mg/kg diazepam as a reference anxiolytic drug. To investigate any motor effect (i.e., hyperactivity, no changes, or hypoactivity) associated with the treatments, the rats were evaluated in the open field test. TheM. frutescens(25 and 50 mg/kg) andM. grandiflora(50 mg/kg) extracts exerted anxiolytic-like effects during the metestrus-diestrus phase, similar to diazepam, without disrupting spontaneous motor activity. No significant effects of the extracts were detected in either behavioral test during the proestrus-estrus phase, whereas diazepam produced motor hypoactivity in the open field test. These results indicate that theM. frutescensandM. grandifloraextracts possess anxiolytic-like effects that depend on the ovarian cycle phase, supporting the Mexican ancient medicinal use of these plants to ameliorate anxiety disorders.

scholarly journals Subconvulsive Dose of Kainic Acid Transiently Increases the Locomotor Activity of Adult Wistar Rats

2015 ◽  
pp. 263-267 ◽  
Author(s):  
V. RILJAK ◽  
D. MAREŠOVÁ ◽  
J. POKORNÝ ◽  
K. JANDOVÁ
Keyword(s):  
Open Field ◽  
Kainic Acid ◽  
Field Test ◽  
Wistar Rats ◽  
Open Field Test ◽  
Neuronal Degeneration ◽  
Neuronal Damage ◽  
Fluoro Jade B ◽  
Behavioral Parameters ◽  
Convulsive Seizures

Kainic acid (KA) is a potent neurotoxic substance valuable in research of temporal lobe epilepsy. We tested how subconvulsive dose of KA influences spontaneous behavior of adult Wistar rats. Animals were treated with 5 mg/kg of KA and tested in Laboras open field test for one hour in order to evaluate various behavioral parameters. Week after the KA treatment animals were tested again in Laboras open field test. Finally, rat’s brains were sliced and stained with Fluoro-Jade B to detect possible neuronal degeneration. Treatment with KA increased the time spent by locomotion (p<0.01), exploratory rearing (p<0.05) and animals traveled longer distance (p<0.01). These parameters tended to increase thirty minutes after KA administration. Week after the treatment we did not found differences in any measured behavioral parameter. Histology in terms of Fluoro-Jade B staining did not reveal any obvious neuronal damage in hippocampus. These results demonstrate that subconvulsive KA dose changes the behavioral parameters only transiently. Clarification of timing of the KA induced changes may contribute to understand mutual relationship between non-convulsive seizures and behavioral/cognitive consequences.

Sex differences in the elevated plus-maze test and large open field test in adult Wistar rats

2021 ◽  
Vol 204 ◽  
pp. 173168
Author(s):  
Parker Knight ◽  
Ranjithkumar Chellian ◽  
Ryann Wilson ◽  
Azin Behnood-Rod ◽  
Stefany Panunzio ◽  
...  
Keyword(s):  
Sex Differences ◽  
Open Field ◽  
Field Test ◽  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Open Field Test ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze

scholarly journals The effects of aqueous extract of Origanum vulgare on learning and memory in male rats

2020 ◽  
Vol 9 (3) ◽  
pp. 239-244
Author(s):  
Ahvan Ghaderi ◽  
Seyed Asaad Karimi ◽  
Fahimeh Talaei ◽  
Siamak Shahidi ◽  
Nafiseh Faraji ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
Learning And Memory ◽  
Open Field ◽  
Field Test ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Open Field Test ◽  
Control Group ◽  
Origanum Vulgare ◽  
Male Wistar Rats

Introduction: The effectiveness of antioxidants on learning and memory improvement has been shown, previously. Due to the high level of antioxidants, available in Origanum vulgare, the present experiment aimed to examine the effect of aqueous extract of O. vulgare on passive avoidance learning (PAL) in male Wistar rats. Methods: This study was performed on 30 male Wistar rats weighing 250 to 290 g. The rats were randomly assigned into five groups (n=6), as follows: the control, sham (saline), and three groups treated with different doses of O. vulgare extract (150, 250, and 350 mg/kg). The saline or extract was administered via daily oral gavage for 14 days. The groups were then subjected to the passive avoidance task, and their behaviors were recorded. The rats’ locomotor activity was also measured using the open field test. Results: The number of trials to acquisition was significantly lower in the "O. vulgare (350 mg/ kg)" group than the control group. The step-through latency and the time spent in the dark compartment in the retention test, was significantly higher and lower in the "O. vulgare (250 and 350 mg/kg)" groups than the control group, respectively. No significant differences were found in the distances traveled among the experimental groups in the open field test. Conclusion: Aqueous extract of O. vulgare can enhance learning and memory. The high levels of antioxidants in O. vulgare extract may be responsible for its effectiveness in learning and memory.

scholarly journals Toxicity and Neuropharmacological Effects of Elenine

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Eduardo Navarro ◽  
S. J. Alonso ◽  
R. Navarro
Keyword(s):  
Open Field ◽  
Field Test ◽  
Chemical Structure ◽  
Open Field Test ◽  
Control Group ◽  
General Behaviour ◽  
Similar Chemical ◽  
Sedative Effects ◽  
Traction Test ◽  
Central Depressant

Elenine is the aglycone of elenoside, a cytotoxic arylnaphthalene lignan (NSC 644013-W/1) derived fromJusticia hyssopifolia. (Family: Acanthaceae). Elenoside is a β-D-glucoside, with a similar chemical structure to etoposide, exhibiting central depressant activity. In the present study, elenine was given to mice and rats at doses of 10, 20, and 40 mg/kg. Acute toxicity (24 h) and general behaviour in mice was studied as well as its effects on muscular relaxant activity, locomotor activity (Varimex test), and the open-field test and were compared with 10 mg/kg of chlorpromazine. Elenine produced a reduction in the permanence time in muscular relaxant activity (traction test). Spontaneous activity was lower in the Varimex test. The ambulation and rearing were lower compared with the control group, and an increase in boluses was observed in the open-field test. Thus, it can be concluded that elenine has central sedative effects at lower doses than those used with elenoside and has a possible application in conditions of anxiety.

Acute effects of ethanol on behavioral responses of male and female zebrafish in the open field test with the influence of a non-familiar object

2021 ◽  
pp. 104474
Author(s):  
Thiele P. Souza ◽  
Francini Franscescon ◽  
Flavia V. Stefanello ◽  
Talise E. Müller ◽  
Laura W. Santos ◽  
...  
Keyword(s):  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Behavioral Responses ◽  
Familiar Object ◽  
Acute Effects ◽  
Male And Female ◽  
Female Zebrafish
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