Developing Mg-Zn-Fish Bone Derived Hydroxyapatite Composites for Biomedical Applications: In vitro Degradation Studies

The study of magnesium (Mg) based biomaterials has emerged as a potential research area in recent times. Controlling the rapid corrosion and improving the implant-tissue interface kinetics for better tissue regeneration are the prime interests behind developing novel Mg-based composites. In the current work, the metal matrix composites of Mg-Zn, dispersed with nano-hydroxyapatite derived from fish bones (fHA), were produced by powder metallurgy route. The powders were mixed with the help of ball milling in the presence of ethanol and then sintered at 440 °C. From the microstructural studies, micro-lamellar morphology was noticed for the sintered compacts due to the flake-like morphology of the milled powders. The sintered compacts were then subjected to in vitro biodegradation studies in simulated conditions for one week. From the results, the presence of fHA was found to be highly influential in increasing the rate of mineral deposition on the surface of the composites. These higher mineral depositions protected the surface of the composites from further degradation. The results demonstrate that adding fHA to Mg accelerates biomineralization and controls degradation, leading to better implant-tissue interactions.

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In vitro degradation profiles and in vivo biomaterial–tissue interactions of microwell array delivery devices

Journal of Biomedical Materials Research Part B Applied Biomaterials ◽

10.1002/jbm.b.34686 ◽

2020 ◽

Vol 109 (1) ◽

pp. 117-127 ◽

Cited By ~ 1

Author(s):

Elahe Hadavi ◽

Rick H.W. Vries ◽

Alexandra M. Smink ◽

Bart Haan ◽

Jeroen Leijten ◽

...

Keyword(s):

In Vitro Degradation ◽

Tissue Interactions ◽

Microwell Array

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In vitro degradation and surface bioactivity of iron-matrix composites containing silicate-based bioceramic

Bioactive Materials ◽

10.1016/j.bioactmat.2016.12.001 ◽

2017 ◽

Vol 2 (1) ◽

pp. 10-18 ◽

Cited By ~ 10

Author(s):

Sanguo Wang ◽

Yachen Xu ◽

Jie Zhou ◽

Haiyan Li ◽

Jiang Chang ◽

...

Keyword(s):

Matrix Composites ◽

Iron Matrix ◽

In Vitro Degradation

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Fabrication of novel magnesium-matrix composites and their mechanical properties prior to and during in vitro degradation

Journal of the Mechanical Behavior of Biomedical Materials ◽

10.1016/j.jmbbm.2016.10.010 ◽

2017 ◽

Vol 67 ◽

pp. 74-86 ◽

Cited By ~ 16

Author(s):

Sina Naddaf Dezfuli ◽

Sander Leeflang ◽

Zhiguang Huan ◽

Jiang Chang ◽

Jie Zhou

Keyword(s):

Mechanical Properties ◽

Matrix Composites ◽

Magnesium Matrix ◽

In Vitro Degradation ◽

Magnesium Matrix Composites

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In Vitro Degradation Of beta-Amyloid[25-35] Peptide

Protein and Peptide Letters ◽

10.2174/0929866013409076 ◽

2001 ◽

Vol 8 (6) ◽

pp. 423-428 ◽

Cited By ~ 1

Author(s):

Krisztina Jost ◽

Jozsef Varga ◽

Botond Pence ◽

Marta Zarandi

Keyword(s):

Beta Amyloid ◽

In Vitro Degradation

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In Vitro Degradation of Absorbable Zinc Alloys in Artificial Urine

Materials ◽

10.3390/ma12020295 ◽

2019 ◽

Vol 12 (2) ◽

pp. 295 ◽

Cited By ~ 11

Author(s):

Sébastien Champagne ◽

Ehsan Mostaed ◽

Fariba Safizadeh ◽

Edward Ghali ◽

Maurizio Vedani ◽

...

Keyword(s):

Surface Characterization ◽

Urinary Tract Obstruction ◽

Calcium Content ◽

Corrosion Layer ◽

Uniform Corrosion ◽

In Vitro Degradation ◽

Pure Zinc ◽

Zinc Alloys ◽

Artificial Urine

Absorbable metals have potential for making in-demand rigid temporary stents for the treatment of urinary tract obstruction, where polymers have reached their limits. In this work, in vitro degradation behavior of absorbable zinc alloys in artificial urine was studied using electrochemical methods and advanced surface characterization techniques with a comparison to a magnesium alloy. The results showed that pure zinc and its alloys (Zn–0.5Mg, Zn–1Mg, Zn–0.5Al) exhibited slower corrosion than pure magnesium and an Mg–2Zn–1Mn alloy. The corrosion layer was composed mostly of hydroxide, carbonate, and phosphate, without calcium content for the zinc group. Among all tested metals, the Zn–0.5Al alloy exhibited a uniform corrosion layer with low affinity with the ions in artificial urine.

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Chemical And Immunochemical Studies On The In Vivo And In Vitro Degradation Of Peptidoglycan Subunits And Cell Wall Complexes In Relation To Inflammatory Diseases

Biological Properties of Peptidoglycan ◽

10.1515/9783110874297-009 ◽

1986 ◽

pp. 61-66

Author(s):

A. Fox ◽

J. Gilbart ◽

J. Harrison ◽

G. Pararajasegaram ◽

A. Wells ◽

...

Keyword(s):

Cell Wall ◽

Inflammatory Diseases ◽

In Vitro Degradation

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Antioxidant and Cryoprotective Effects of Bone Hydrolysates from Bighead Carp (Aristichthys nobilis) in Freeze-Thawed Fish Fillets

Foods ◽

10.3390/foods10061409 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1409

Author(s):

Yiqi Zhang ◽

Ye Dong ◽

Zhiyuan Dai

Keyword(s):

Antioxidant Activity ◽

Thiobarbituric Acid ◽

Fish Bone ◽

Bighead Carp ◽

Vacuum Impregnation ◽

Ferrous Ions ◽

Freezing And Thawing ◽

Aristichthys Nobilis ◽

Fish Fillets

Bone hydrolysates from bighead carp (Aristichthys nobilis) were prepared using Protamex and Alcalase with degrees of hydrolysis (DH) of 5%, 10% and 15%. The antioxidant activity of bone hydrolysates was evaluated in vitro and then the hydrolysates with better antioxidant activity were used to immerse bighead carp fillets through a vacuum impregnation process at concentrations of 1% and 2%. Among the six hydrolysates, fish bone hydrolyzed with Protamex at DH 10% exhibited the highest ability to scavenge 1, 1-diphenyl-2-picrylhydrazyl (DPPH) (88.79%), 2, 2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) (57.76%) and hydroxyl radicals (62.72%), as well as to chelate ferrous ions (91.46%). The hydrolysates effectively postponed freezing- and thawing-induced protein/lipid oxidation. Compared with the fillets without treatment, the impregnated fillets had higher sulfhydryl contents, greater Ca2+-ATPase activity, lower carbonyls and lower thiobarbituric acid-reactive substances (TBARS). Bone hydrolysates also have a positive effect on the texture and water-holding ability of freeze-thawed fish fillets. Fish bone hydrolysates of Protamex could serve as potential antioxidants to preserve fish fillets.

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