scholarly journals Studying of the incidence of inflammatory processes and vaginal bacterial flora in polycystic ovary syndrome under conditions of increased

2018 ◽  
Vol 82-83 (2-3) ◽  
pp. 71-77
Author(s):  
S.V. Gunkov
Keyword(s):  
Escherichia Coli ◽  
Polycystic Ovary Syndrome ◽  
Sexually Transmitted Infections ◽  
Enterococcus Faecalis ◽  
Polycystic Ovary ◽  
Bacterial Flora ◽  
Ovary Syndrome ◽  
Sexually Transmitted ◽  
Vaginal Microflora ◽  
Inflammatory Processes

In previous studies, high serum concentrations of manganese and nickel were established in women with polycystic ovary syndrome (PCOS). Increased level of exposure of the population of Ukraine to manganese and nickel has been demonstrated. The objective of this study is studying the incidence of inflammatory processes and composition of vaginal bacterial flora in healthy women and in women with PCOS. Materials and methods. The control group consisted of 57 women without reproductive system conditions and 64 women who had established PCOS according to the Rotterdam Consensus criteria. In both groups, the presence of sexually transmitted infections was excluded by PCR. The analysis of the incidence of inflammatory processes was carried out according to the microscopic characteristics of vaginal microbiocenosis. Vaginal microflora was examined by the culture method. Evaluation of the resulting validity was performed using Student’s t-test, Mann-Whitney U-test and χ2. Results. Studies have shown that women with PCOS are much more likely to show signs of inflammatory processes in the vagina, as well as colonization of vagina with bacteria and fungi. Compared to control, lactobacilli are less common, while the diversity of bacterial flora is increasing, with a predominance of the representatives of intestinal flora (Enterococcus faecalis, Escherichia coli) and Candida albicans. The analysis of quantitative parameters showed a significant decrease in Lactobacillus spp. (Р=0,0003), increase in Escherichia coli (Р=0,0026), Enterococcus faecalis (Р=0,0003), and Enterococcus Durans (Р=0,0272). Meanwhile, the quantitative parameters of other representatives of the vaginal microflora virtually did not change compared with the control. Conclusion. Inflammatory processes in PCOS may not be associated with sexually transmitted infections or body mass index. Increased exposure to manganese and nickel can affect vaginal microflora and its individual representatives. Key words: polycystic ovary syndrome, inflammation, microflora, vagina, manganese, nickel.

scholarly journals Polycystic ovary syndrome – 80 years of research and new directions in the study (literature review)

2016 ◽  
Vol 1 (5) ◽  
pp. 181-186 ◽  
Author(s):  
Дамдинова ◽  
Lyudmila Damdinova ◽  
Лещенко ◽  
Olga Leshchenko
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Depressive Disorders ◽  
Peptide Yy ◽  
Polycystic Ovary ◽  
Bacterial Flora ◽  
Molecular Genetic ◽  
Scientific Work ◽  
Current Data ◽  
Hormonal Contraceptives ◽  
Ovary Syndrome

The article presents the current data of history of polycystic ovary syndrome (PCOS) study. It contains studies of genetic susceptibility of PCOS, PCOS symptoms and connection with development of anxiety and depressive disorders. The article covers ethnic differences in the phenotypic manifestations of PCOS. The papers describes the study of endocrine causes of infertility in Russian and Buryat women. Several theories of PCOS, including the theory of PCOS connection with intestinal bacterial flora disorders (“dysbiotic intestinal microbiota”) are being discussed. The article also provides an overview of various scientific research in this area and the data of the relationship of PCOS and the risk of cardiometa-bolic disorders, insulin resistance, metabolic syndrome, obesity and sleep apnea. It highlights modern aspects in the study of PCOS etiology – studies of adipose tissue as an endocrine organ. The article reflects study of PCOS relationship with the level of the gastrointestinal tract hormones: leptin, insulin, ghrelin, cholecystokinin, peptide YY. The effect of short-term low-dose hormonal contraceptives on appetite levels in PCOS is covered. The scientific articles on the severity of hypertension in menopausal women with PCOS history and the presence of overweight are reviewed. The scientific work determines molecular genetic markers of PCOS in the aspect of the influence of environmental factors on the expression of genes.

The role of vitamin D in metabolic and reproductive disturbances of polycystic ovary syndrome: A narrative mini-review

2020 ◽  
pp. 1-8
Author(s):  
Daniela Menichini ◽  
Gianpiero Forte ◽  
Beatrice Orrù ◽  
Giuseppe Gullo ◽  
Vittorio Unfer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Embryo Quality ◽  
Polycystic Ovary ◽  
Vitamin D Supplementation ◽  
Endometrial Receptivity ◽  
Metabolic Disturbances ◽  
Ovary Syndrome ◽  
Beneficial Role

Abstract. Vitamin D is a secosteroid hormone that plays a pivotal role in several metabolic and reproductive pathways in humans. Increasing evidence supports the role of vitamin D deficiency in metabolic disturbances and infertility in women with polycystic ovary syndrome (PCOS). Indeed, supplementation with vitamin D seems to have a beneficial role on insulin resistance and endometrial receptivity. On the other hand, exceedingly high levels of vitamin D appear to play a detrimental role on oocytes development and embryo quality. In the current review, we summarize the available evidence about the topic, aiming to suggest the best supplementation strategy in women with PCOS or, more generally, in those with metabolic disturbances and infertility. Based on the retrieved data, vitamin D seems to have a beneficial role on IR, insulin sensitivity and endometrial receptivity, but high levels and incorrect timing of administration seem to have a detrimental role on oocytes development and embryo quality. Therefore, we encourage a low dose supplementation (400–800 IU/day) particularly in vitamin D deficient women that present metabolic disturbances like PCOS. As far as the reproductive health, we advise vitamin D supplementation in selected populations, only during specific moments of the ovarian cycle, to support the luteal phase. However, ambiguities about dosage and timing of the supplementation still emerge from the clinical studies published to date and further studies are required.

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