scholarly journals Henoch-Schönlein Purpura Nephritis in Children: A Review

2014 ◽  
Vol 38 (1) ◽  
pp. 24-31
Author(s):  
Golam Muin Uddin ◽  
Afroza Begum
Keyword(s):  
Leukocytoclastic Vasculitis ◽  
Treatment Options ◽  
Renal Involvement ◽  
Henoch Schonlein Purpura ◽  
Multiple Organs ◽  
Systemic Disorder ◽  
Stage Renal Disease ◽  
End Stage ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schönlein purpura (HSP) is a systemic disorder which involves multiple organs including kidney. The characteristic pathology is leukocytoclastic vasculitis of the capillaries with deposition of IgA immune complexes. The principal cause of morbidity and mortality in this disease is due to renal involvement. Approximately half of the children with HSP develop nephritis (HSPN) within 4-6 weeks of initial presentation and HSPN is a major cause of end stage renal disease (ESRD) in children. So, it is important to be updated about aetio-pathogensis, clinico-pathological aspects and prognostic factors of nephritis related to Henoch Schonlein purpura. The most important is to identify the appropriate treatment options for HSPN. So, herein review has been done on the different aspects of HSPN including treatment. DOI: http://dx.doi.org/10.3329/bjch.v38i1.20024 Bangladesh J Child Health 2014; VOL 38 (1) : 24-31

scholarly journals Henoch Schonlein Purpura as a Cause of Renal Failure in an Adult

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Shweta Kukrety ◽  
Pradeepa Vimalachandran ◽  
Rajesh Kunadharaju ◽  
Vishisht Mehta ◽  
Agnes Colanta ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Renal Involvement ◽  
High Dose ◽  
Henoch Schonlein Purpura ◽  
Increased Risk ◽  
Stage Renal Disease ◽  
End Stage ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch Schonlein purpura (HSP) is an immune mediated disease associated Immunoglobulin A (IgA) deposition within the affected organs. While the disease is commonly seen in the pediatric age group, it is rarely seen in adults. We report the case of a 93-year-old Caucasian lady who presented with nonthrombocytopenic purpuric rash and acute kidney injury after an episode of bronchitis. Rapid and progressive deterioration of renal function prompted a kidney biopsy, which showed findings consistent with IgA nephropathy confirming the diagnosis of HSP. The patient was treated with high dose intravenous methylprednisolone followed by oral prednisone; however, her kidney disease progressed to end stage renal disease requiring hemodialysis. HSP is usually a self-limiting disease in children. However, adults are at an increased risk of severe renal involvement including end stage renal disease. Purpuric skin rash with renal involvement should raise suspicion for HSP. This is the oldest known patient with HSP.

scholarly journals Henoch-Schonlein Purpura—A Case Report and Review of the Literature

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Amit B. Sohagia ◽  
Srinivas Guptha Gunturu ◽  
Tommy R. Tong ◽  
Hilary I. Hertan
Keyword(s):  
Early Recognition ◽  
Leukocytoclastic Vasculitis ◽  
Systemic Disease ◽  
Renal Involvement ◽  
Symptomatic Treatment ◽  
Adolescent Male ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

We describe a case of an adolescent male with Henoch-Schonlein purpura (HSP), presenting with cutaneous and gastrointestinal manifestations. Endoscopy revealed diffuse ulcerations in the stomach, duodenum, and right colon. Biopsies revealed a leukocytoclastic vasculitis in the skin and gastrointestinal tract. Steroid therapy led to complete resolution of the symptoms. HSP is the most common childhood vasculitis, and is characterized by the classic tetrad of nonthrombocytopenic palpable purpura, arthritis or arthralgias, gastrointestinal and renal involvement. It is a systemic disease where antigen-antibody (IgA) complexes activate the alternate complement pathway, resulting in inflammation and small vessel vasculitis. Mild disease resolves spontaneously, and symptomatic treatment alone is sufficient. Systemic steroids are recommended for moderate to severe HSP. The prognosis depends upon the extent of renal involvement, which requires close followup. Early recognition of multiorgan involvement, especially outside of the typical age group, as in our adolescent patient, and appropriate intervention can mitigate the disease and limit organ damage.

scholarly journals ADULT ONSET HENOCH: SCHONLEIN PURPURA – AN UNUSUAL PRESENTATION

2017 ◽  
Vol 10 (10) ◽  
pp. 2
Author(s):  
Srujith Chandrakanti ◽  
Oshin Mantro ◽  
Jagadeesan Mohanan ◽  
Mervin Kayipirambil Soman ◽  
Prasanna Karthik Suthakaran ◽  
...  
Keyword(s):  
Rare Case ◽  
Early Recognition ◽  
Leukocytoclastic Vasculitis ◽  
Renal Involvement ◽  
Unusual Presentation ◽  
Organ Involvement ◽  
Adult Onset ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

  Henoch–Schonlein purpura (HSP) is a common leukocytoclastic vasculitis seen in children. However, it is uncommon in adults. HSP is characterized by the classic tetrad of non-thrombocytopenic palpable purpura, arthritis or arthralgias, gastrointestinal, and renal involvement. We report a rare case of adult onset HSP with multi-organ involvement. Early recognition of multi-organ involvement is very important, especially in adults.

PRESENTATION OF HENOCH SCHONLEIN PURPURA IN AN ELDERLY MAN WITH END STAGE RENAL DISEASE

CHEST Journal ◽  
2019 ◽  
Vol 156 (4) ◽  
pp. A1300-A1301
Author(s):  
Olaoluwatomi Lamikanra ◽  
Steve Obanor ◽  
Karen Tuneev ◽  
Vignesh Ponnusamy ◽  
Chanaka Seneviratne ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Henoch Schonlein Purpura ◽  
Stage Renal Disease ◽  
End Stage ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

scholarly journals 119 Location of skin lesions in Henoch-Schonlein purpura (HSP) and its association with renal involvement

2016 ◽  
Vol 136 (5) ◽  
pp. S22
Author(s):  
J. St. John ◽  
A. Garza-Mayers ◽  
P. Vedak ◽  
M. Hoang ◽  
S. Nigwekar ◽  
...  
Keyword(s):  
Renal Involvement ◽  
Skin Lesions ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Location of skin lesions in Henoch-Schönlein purpura and its association with significant renal involvement

2018 ◽  
Vol 78 (1) ◽  
pp. 115-120 ◽  
Author(s):  
Jessica St. John ◽  
Priyanka Vedak ◽  
Anna Cristina Garza-Mayers ◽  
Mai P. Hoang ◽  
Sagar U. Nigwekar ◽  
...  
Keyword(s):  
Renal Involvement ◽  
Skin Lesions ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

scholarly journals Neutrophil-to-lymphocyte Ratio: A Biomarker for Predicting Systemic Involvement in Henoch–Schonlein Purpura

2021 ◽  
Vol 0 ◽  
pp. 1-4
Author(s):  
Wang Lei ◽  
Shan Yun-Yun ◽  
Xu Ai-E
Keyword(s):  
Inflammatory Marker ◽  
Renal Involvement ◽  
Neutrophil To Lymphocyte Ratio ◽  
Henoch Schonlein Purpura ◽  
Systemic Involvement ◽  
Lymphocyte Ratio ◽  
Number Of Patients ◽  
Pre Treatment ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Background: Henoch–Schonlein purpura (HSP) is one of the commonest entities included within the category of cutaneous vasculitis (CV). Our work is purposed to explore the predictive value of neutrophil-to-lymphocyte ratio (NLR) for systemic involvement in Henoch– Schonlein purpura patients. This ratio is known as an inflammatory marker, and is used to assess the systemic inflammation associated with various diseases. Our objective is to establish whether it can be applied for the prediction of renal and gastrointestinal (GI) or purely renal involvement in Henoch–Schonlein purpura. Aim: To determine the relationship between neutrophil-to-lymphocyte ratio and systemic involvement in Henoch–Schonlein purpura Methods: This is a retrospective review of the patients who were diagnosed with Henoch–Schonlein purpura in our hospital between 2012 and 2018. Results: A total of 57 patients met our inclusion criteria. Pre-treatment neutrophil-to-lymphocyte ratio was significantly associated with renal and/or GI manifestations of the disease (p<0.001). The optimal cut-off value of this ratio for predicting systemic involvement was 2.48, with a 95% specificity and a 94% sensitivity. In addition, pretreatment ratio was also found to be significantly correlated with the severity of relevant systemic manifestations of Henoch–Schonlein purpura (r=0.831; p<0.01). Limitations: The small number of patients recruited for our research, its retrospective design, and the inclusion of patients attending the same hospital. Conclusion: This study suggests that neutrophil-to-lymphocyte ratio is suitable as a potential indicator for predicting the systemic involvement in Henoch–Schonlein purpura.

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