scholarly journals Effect of Metformin and Clomiphene Citrate in Improving Fertility in Subfertile Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial

2016 ◽  
Vol 29 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Hasina Begum ◽  
TA Chowdhury ◽  
Ferdousi Begum ◽  
Shamsun Nahar Begum ◽  
Nazneen Kabir ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Pregnancy Rate ◽  
Polycystic Ovary ◽  
Controlled Trial ◽  
Clomiphene Citrate ◽  
Serum Progesterone ◽  
Randomized Controlled ◽  
Group I ◽  
Baseline Characteristics ◽  
Per Oral

Objective: The main aim of this study was to compare the effect of metformin and clomiphene citrate on ovulation and conception rate in PCOS patients.Methodology: This randomized controlled trial was undertaken in the infertility outpatient department in Institute of Child and Maternal Health (ICMH), Dhaka during the period from January 2012 to December 2012. Total 71 PCOS women based on Rotterdam criteria were selected after randomization. They were divided into two groups - Group I (n=35) received metformin 500mg per oral thrice daily and Group II (n= 36) received clomiphene citrate 100mg orally per day from D2 for five days up-to six months.Results: Baseline characteristics of both sample groups were almost similar. Ovulation was confirmed by measuring D21 serum progesterone. Cumulative ovulation rate over six months period was not statistically different (57.14 % and 61.11%); (P=0.115), and pregnancy rate was (34.28 % and 42.85%); (P=0.521)respectively.Conclusion: Metformin has been found to be as effective as clomiphene citrate in terms of ovulation (57.14 % and 61.11%); and pregnancy rate (34.28 % and 42.85%) respectivelyBangladesh J Obstet Gynaecol, 2014; Vol. 29(1) : 15-20

scholarly journals Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Hongying Kuang ◽  
Yan Li ◽  
Xiaoke Wu ◽  
Lihui Hou ◽  
Taixiang Wu ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Polycystic Ovary Syndrome ◽  
Live Birth ◽  
Polycystic Ovary ◽  
Controlled Trial ◽  
Clomiphene Citrate ◽  
Fertility Treatment ◽  
Ovary Syndrome ◽  
Randomized Controlled ◽  
Multicenter Randomized Controlled Trial

Acupuncture is an alternative therapy to induce ovulation in women with polycystic ovary syndrome (PCOS), but there is no study reporting the live birth rate following ovulation induction by acupuncture or its potential as an adjuvant treatment to clomiphene citrate (CC). We assess the efficacy of acupuncture with or without CC in achieving live births among 1000 PCOS women in Mainland China. This paper reports the methodology of an ongoing multicenter randomized controlled trial. The randomization scheme is coordinated through the central mechanism and stratified by the participating sites. Participants will be randomized into one of the four treatment arms: (A) true acupuncture and CC, (B) control acupuncture and CC, (C) true acupuncture and placebo CC, and (D) control acupuncture and placebo CC. To ensure the quality and integrity of the trial we have developed a unique multinational team of investigators and Data and Safety Monitoring Board. Up to the end of April 2013, 326 subjects were recruited. In conclusion, the success of this trial will allow us to evaluate the additional benefit of acupuncture beyond the first line medicine for fertility treatment in PCOS women in an unbiased manner.

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