scholarly journals Effects of Cimetidine and Phenobarbitone on Paracetamol Induced Hepatotoxic Rats

1970 ◽  
pp. 13-15
Author(s):  
Layla Afroza Banu ◽  
Hosne Ara Begum ◽  
SAR Choudhury
Keyword(s):  
Enzyme System ◽  
Treated Group ◽  
Protective Role ◽  
Significant Rise ◽  
Alanine Transaminase ◽  
Aspartate Transaminase ◽  
Simultaneous Administration ◽  
Microsomal Enzyme ◽  
Hepatic Microsomal Enzyme ◽  
Long Evans

The effects of cimetidine and phenobarbitone on paracetamol induced hepatotoxicity were studied in Long Evans Norwegian strain rats of either sexes. Orally administration of paracetamol 150 mg/ kg body weight for 21 days. On 22nd days after treatment there was significant increase of serum Alanine transaminase (AST), Aspartate transaminase (AST) and Alkaline phosphatase (Alk. phos) level. Orally administration of phenobarbitone 20 mg/kg b.w. along with paracetamol produced highly significant rise of serum ALT, AST and Alk. phos, levels as compared to the paracetamol treated group. But simultaneous administration of paracetamol and cimetidine produced significant decrease of serum ALT, AST and Alk. phos.level. When phenobarbitone is used concurrently with paracetamol, induced hepatic microsomal enzyme system which in turn aggravates the paracetamol induced hepatotoxicity but when cimetidine was administered simultaneously with paracetamol inhibited hepatic microsomal enzyme system and exhibits a protective role on paracetamol induced hepatotoxicity.The experiment was designed to demonstrate the effect of paracetamol on hepatotoxicity and its prevention by simultaneous administration of cimetidine. Further experiment was also designed to demonstrate the induction of hepatic microsomal enzyme system (HMES) by phenobarbitone on paracetamol induced hepatotoxicity. DOI: 10.3329/bjpp.v23i1.5725Bangladesh J Physiol Pharmacol 2007; 23(1&2) : 13-15

A rifampicin-induced hepatic microsomal enzyme system for the generation of cyclosporine metabolites

1995 ◽  
Vol 32 (3) ◽  
pp. 141-148 ◽  
Author(s):  
M.B. Tamolang ◽  
W.T. Liu ◽  
H. Pang ◽  
Ying Ren ◽  
P.Y. Wong
Keyword(s):  
Enzyme System ◽  
Microsomal Enzyme ◽  
Hepatic Microsomal Enzyme

Cholesterol 7α-hydroxylase—Evidence for a distinct hepatic microsomal enzyme system

1978 ◽  
Vol 27 (7) ◽  
pp. 1055-1062 ◽  
Author(s):  
William S. Mellon ◽  
Donald T. Witiak ◽  
Dennis R. Feller
Keyword(s):  
Enzyme System ◽  
Microsomal Enzyme ◽  
Hepatic Microsomal Enzyme

Hepatic microsomal enzyme activity in patients with non-insulin dependent diabetes mellitus (NIDDM) and its clinical significance

1983 ◽  
Vol 104 (4_Suppl) ◽  
pp. S125-S129 ◽  
Author(s):  
Eero A Sotaniemi ◽  
Arno J Arranto ◽  
Pasi I Salmela ◽  
Jari H Stengård ◽  
R Olavi Pelkonen
Keyword(s):  
Diabetes Mellitus ◽  
Enzyme Activity ◽  
Enzyme System ◽  
Insulin Dependent Diabetes ◽  
Microsomal Enzyme ◽  
Hepatic Microsomal Enzyme ◽  
Insulin Dependent

ABSTRACT. Hepatic microsomal enzyme activity was investigated in 280 patients with diabetes mellitus. The oral antipyrine test was used as an in vivo index, and cytochrome P-450 content and arylhydrocarbon hydroxylase activity, determined from liver biopsies (80 subjects), were used as in vitro indices of the liver microsomal enzyme system. Indices of both in vivo and in vitro liver metabolism were decreased in patients with noninsulin dependent diabetes (NIDDM, type 2) as compared to subjects with insulin dependent diabetes (IDDM, type 1) and with age- and sex-matched controls. Drug-induced activation of hepatic enzyme system in type 2 patients having reduced microsomal enzyme activity resulted in improved drug metabolizing ability and also improved glucose utilization. In addition, a decrease of hepatic fat content and a change in serum lipid levels were observed. The function of the hepatocellular endoplasmic reticulum, as measured by microsomal enzyme activity, hence seems to be an important factor in the regulation of glucose metabolism in type 2 diabetics. Key words: Diabetes mellitus, microsomal enzyme activity, blood glucose, liver histology.

scholarly journals CARDIOPROTECTIVE EFFECT OF PHYLLANTHUS FRATERNUS LEAVES EXTRACT AGAINST CYCLOPHOSPHAMIDE - INDUCED MYOCARDIAL INJURY IN RATS

2017 ◽  
Vol 10 (12) ◽  
pp. 280
Author(s):  
Rakesh Singh Moirangthem ◽  
Ngangom Gunindro ◽  
Dipdeba Singh Takhellambam ◽  
Sucheta Devi Khuraijam ◽  
Meena N ◽  
...  
Keyword(s):  
Protective Effect ◽  
Wistar Rats ◽  
Myocardial Injury ◽  
Histopathological Examination ◽  
Protective Role ◽  
Alanine Transaminase ◽  
Aspartate Transaminase ◽  
Cardiac Biomarker ◽  
Phyllanthus Fraternus

Objectives: This study was undertaken to investigate the possible protective effect of aqueous extract of Phyllanthus fraternus (AEPF) leaves against cyclophosphamide (CP) induced myocardial toxicity in rats.Methods: Wistar rats were given CP single intraperitoneally injection (200 mg/kg) on day 1 of the experiment and two doses of AEPF (200 mg/kg and 400 mg/kg) p.o. daily for 10 days. Cardiac biomarker enzymes such as creatinine kinase (CK), CK isoenzyme MB, lactate dehydrogenase, alkaline phosphatase, alanine transaminase, and aspartate transaminase were determined. Histopathological examinations of the hearts were done.Results: CP treated groups exhibited significantly increased in cardiac biomarker enzymes. Treatment with AEPF prevented the elevation of these enzymes. Potential protective effect was also seen in histopathological examination of the heart characterized by decreased myocardium cell damages in AEPF treatment group.Conclusion: The study showed the protective role of AEPF against CP-induced myocardial injury. The possible role of antioxidant activity is anticipated.

scholarly journals Enzyme Induction by Drugs

1978 ◽  
Vol 15 (1-6) ◽  
pp. 55-64 ◽  
Author(s):  
William J. Marshall
Keyword(s):  
Enzyme Induction ◽  
Metabolic Regulation ◽  
Enzyme System ◽  
Microsomal Enzyme ◽  
Hepatic Microsomal Enzyme ◽  
Metabolic Bone ◽  
Bilirubin Metabolism ◽  
The Relationship ◽  
Endogenous Substances

Summary The properties of the hepatic microsomal, drug detoxicating, enzyme system are reviewed with particular reference to its inducibility. Induction is modified by various factors of which the diet is particularly important. A theoretical model system for induction has been proposed and this is discussed. There are a number of methods for assessing microsomal enzyme induction in man, none of which is ideal. Nevertheless, induction is a well recognised phenomenon in man and has a bearing on the metabolism of a number of endogenous substances. The effect of induction on steroid metabolism and the relationship between inducers, vitamin D, and metabolic bone disease is discussed. Bilirubin metabolism is affected by changes in microsomal enzyme activity and inducers have been used therapeutically in some cases of hyperbilirubinaemia. The relationship between drugs and the hepatic porphyrias is reviewed. The hepatic microsomal enzyme system is but one of many inducible enzymes and the role of induction in general in metabolic regulation is emphasised.

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