scholarly journals Antidiabetic effect of syzygium cumini l. Seed on type 2 diabetic rats

1970 ◽  
Vol 19 (2) ◽  
pp. 157-164 ◽  
Author(s):  
Zaied Ahmed Bhuyan ◽  
Begum Rokeya ◽  
Nuruzzaman Masum ◽  
Shahdat Hossain ◽  
Ishtiaq Mahmud
Keyword(s):  
Cholesterol Level ◽  
Glucose Level ◽  
Glycogen Content ◽  
Ethanol Extract ◽  
Liver Glycogen ◽  
Diabetic Rats ◽  
Syzygium Cumini ◽  
Liver Glycogen Content ◽  
Type 2 Diabetic

The present study evaluates the effects of powder and ethanol extract of Syzygium cumini seeds (1.25/ kg bw) treatment for 21 days on glucose homeostasis, serum insulin, serum lipids and liver glycogen content in streptozotocin (STZ) induced type 2 diabetic rats. The administration of S. cumini seed powder and ethanol extract for 21 days to type 2 diabetic rats significantly reduced the fasting glucose level although it did not alter the blood glucose level after glucose challenge. The insulin level and liver glycogen content also were not changed after dietary administration of Syzygium cumin powder or ethanol extract. In addition to hypoglycemic effect, the Syzygium cumini significantly ameliorated the lipid profile. The plasma LDL?cholesterol level, an atherogenic lipid, significantly (p < 0.01) decreased with a concurrent increase (p < 0.01) in the plasma HDL?cholesterol level, thus suggesting dietary Syzygium cumini could be used as one of the alternatives in the treatment of diabetes.    Key words: Syzygium cumini; Diabetes; Cholesterol DOI: http://dx.doi.org/10.3329/dujbs.v19i2.8959 DUJBS 2010; 19(2): 157-164

scholarly journals Ethanol extract of mulberry leaves partially restores the composition of intestinal microbiota and strengthens liver glycogen fragility in type 2 diabetic rats

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhan-Zhong Liu ◽  
Qing-Hua Liu ◽  
Zhao Liu ◽  
Jia-Wei Tang ◽  
Eng-Guan Chua ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Intestinal Microbiota ◽  
Ethanol Extract ◽  
Liver Glycogen ◽  
Diabetic Rats ◽  
Size Exclusion ◽  
Mulberry Leaves ◽  
Positive Effects ◽  
Type 2 Diabetic

Abstract Background Mulberry leaf as a traditional Chinese medicine is able to treat obesity, diabetes, and dyslipidemia. It is well known that diabetes leads to intestinal microbiota dysbiosis. It is also recently discovered that liver glycogen structure is impaired in diabetic animals. Since mulberry leaves are able to improve the diabetic conditions through reducing blood glucose level, it would be interesting to investigate whether they have any positive effects on intestinal microbiota and liver glycogen structure. Methods In this study, we first determined the bioactive components of ethanol extract of mulberry leaves via high-performance liquid chromatography (HPLC) and liquid chromatography/mass spectrometry (LC/MS). Murine animal models were divided into three groups, normal Sprague-Dawley (SD) rats, high-fat diet (HFD) and streptozotocin (STZ) induced type 2 diabetic rats, and HFD/STZ-induced rats administered with ethanol extract of mulberry leaves (200 mg/kg/day). Composition of intestinal microbiota was analyzed via metagenomics by sequencing the V3-V4 region of 16S rDNAs. Liver glycogen structure was characterized through size exclusion chromatography (SEC). Both Student’s t-test and Tukey’s test were used for statistical analysis. Results A group of type 2 diabetic rat models were successfully established. Intestinal microbiota analysis showed that ethanol extract of mulberry leaves could partially change intestinal microbiota back to normal conditions. In addition, liver glycogen was restored from fragile state to stable state through administration of ethanol extract of mulberry leaves. Conclusions This study confirms that the ethanol extract of mulberry leaves (MLE) ameliorates intestinal microbiota dysbiosis and strengthens liver glycogen fragility in diabetic rats. These finding can be helpful in discovering the novel therapeutic targets with the help of further investigations.

scholarly journals Hypoglycemic effect of Irvingia gabonensis (Aubry-Lacomate Ex. Ororke), Baill in Type 2 Diabetic Long-Evans Rats

2012 ◽  
Vol 11 (1) ◽  
pp. 19-24 ◽  
Author(s):  
M S Hossain ◽  
S Sokeng ◽  
M Shoeb ◽  
K Hasan ◽  
M Mosihuzzaman ◽  
...  
Keyword(s):  
Glucose Level ◽  
Serum Insulin ◽  
Liver Glycogen ◽  
Treated Group ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Bush Mango ◽  
Irvingia Gabonensis ◽  
Type 2 Diabetic

Irvingia gabonensis (Aubry-Lacomate Ex. Ororke), Baill (African wild mango/bush mango) seeds are   widely used in cooking as a sauce in Cameroon and in most parts of tropical Africa for the treatment of a number of ailments. In this study normal rat food was incorporated with I. gabonensis seed powder (10%) and oil free seed powder (5%) and their chronic effects on streptozotocin induced Type 2 diabetic rats were studied. Oral consumption of food incorporated with seed powder significantly reduced serum glucose level on the 28th day (p<0.01) which was   comparable with glibenclamide treated group. Food with oil free seed powder showed 24% fall in glucose level on the 28th day. Fasting serum insulin increased significantly (p<0.001) in glibenclamide and oil free seed powder treated (p<0.008) groups. No effect was observed in the seed powder treated group. Liver glycogen content increased in the glibenclamide treated group but no significant change was observed in both powder and oil free seed powder   treated groups. On the 28th day seed powder treated group significantly lowered serum TG level (p<0.033) and 48% was lowered by oil free seed powder. It is concluded that seed powder as well as oil free seed powder lowered blood glucose level in Type 2 diabetic model rats. It seems to act as an insulinomimetic and/or insulin sensitizing agent. DOI: http://dx.doi.org/10.3329/dujps.v11i1.12482 Dhaka Univ. J. Pharm. Sci. 11(1): 19-24, 2012 (June)

Anti-Diabetic Activity of a Polyherbal Formulation in Streptozotocin Induced Type 2 Diabetic Rats

2017 ◽  
Vol 16 (4) ◽  
pp. 148
Author(s):  
Tripathi Nagja ◽  
Vimal Kumar ◽  
Acharya Sanjeev
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Neonatal Rats ◽  
Polyherbal Formulation ◽  
Eugenia Jambolana ◽  
Type 2 Diabetic

The aim of the present study was to determine the anti-diabetic activity of a polyherbal formulation in streptozotocin induced type 2 diabetic rats. The hydroalcoholic extracts of Eugenia jambolana, Gymnema sylvestre, Momordica charantia and Andrographis paniculata and sodhana processed extract of Myristica fragrans were prepared. The 2 day old neonatal rats were injected with 90 mg/kg of streptozotocin intraperitoneally to induce type 2 diabetes. After six weeks of streptozotocin injection, polyherbal formulation was daily administered at a dose of 400 mg/kg body weight to diabetic rats for a period of 28 days. Blood samples were collected from the retro orbital plexus of the eye and blood glucose level was estimated by glucose oxidase-peroxidase method. The study indicated that polyherbal formulation at a dose of 400 mg/kg body weight showed significant decline (p&lt;0.001) in blood glucose level.

scholarly journals Antidiabetic Effects of the Different Fractions of Ethanolic Extracts of Ocimum sanctum in Normal and Alloxan Induced Diabetic Rats

2009 ◽  
Vol 2 (1) ◽  
pp. 158-168 ◽  
Author(s):  
M. R. I. Khan ◽  
M. A. Islam ◽  
M. S. Hossain ◽  
M. Asadujjaman ◽  
M. I. I. Wahed ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glycogen Content ◽  
Fasting Blood Glucose ◽  
Liver Glycogen ◽  
Diabetic Rats ◽  
Ocimum Sanctum ◽  
Liver Glycogen Content ◽  
Glutamate Pyruvate ◽  
Serum Glutamate ◽  
Antidiabetic Effects

The antidiabetic effects of Ethyl acetate (Et-Ac), Petroleum-ether (Pet-ether), and Chloroform fractions from ethanolic extract of the leaves of Ocimum sanctum were investigated in normal and alloxan induced diabetic rats (AIDRs). The effect of these fractions (200 mg/kg body weight i.p) on fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), serum glutamate oxaloacetate transaminases, serum glutamate pyruvate transaminases (SGOT, SGPT) level, and liver glycogen content were investigated in AIDRs and found significant effects. The most significant reduction of FBG level of around 80.19% was observed for Et-Ac fraction in AIDRs. A significant reduction (p< 0.01) in serum TC and TG level of 54.49% and 79.78% respectively was also found for Et-Ac fraction of O. sanctum. The hypoglycemic and hypolipidemic activities were comparable to metformin HCl (150 mg/kg). In severely diabetic rats, liver glycogen content was decreased by 50.60%. Administration of these fractions to the AIDRs resulted in the significant elevation of liver glycogen content. In diabetic rats, SGOT and SGPT levels were significantly elevated that were further reduced after intraperitoneal administration of these fractions. These results indicate that different fractions of O. sanctum have favorable effects in bringing down the severity of diabetes together with hepatoprotectivity. Keywords: Fasting blood glucose; Hypolipidemic; Serum glutamate oxaloacetate transaminases; Serum glutamate pyruvate transaminases; Hepatoprotectivity. © 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v2i1.2769                 J. Sci. Res. 2 (1), 158-168 (2010) 

Sign in / Sign up

Export Citation Format

Share Document