Pregnancy Complications in Women with PCOS: A Meta-Analysis

Polycystic ovary syndrome (PCOS) is a hormonal disorder which affects women in their reproductive ages. There might have association between maternal and neonatal complications with PCOS. The goal of this study is to look for the association between polycystic ovary syndromes (PCOS) and obstetric complications through meta-analysis on the basis of previously published studies from 2000 to 2019. In the current endeavour 17 studies involving 1975 women with PCOS and 10812 controls were selected for pooling. During pregnancy period women who have PCOS showed a significantly higher risk of developing gestational diabetes mellitus (GDM) (RR 2.51; 95% CI: 1.71-3.65), pregnancy induced hypertension (PIH) (RR 2.76; 95% CI: 2.04-3.72), preeclampsia (RR 2.14; 95% CI: 1.34-3.40), preterm birth (RR 1.41; 95% CI: 1.08-1.85) compared to controls. Neonatal birth weight is significantly lower (SMD -0.18; 95% CI: -0.33 to -0.03) compared to controls. It is concluded that women who have PCOS have greater chance of having pregnancy complications as well as risk of neonatal complications such as having low birth weight. Dhaka Univ. J. Sci. 69(2): 82-87, 2021 (July)

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Risks for Gestational Diabetes Mellitus and Pregnancy-Induced Hypertension Are Increased in Polycystic Ovary Syndrome

BioMed Research International ◽

10.1155/2013/182582 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 14

Author(s):

Yunhui Wang ◽

Xiaomiao Zhao ◽

Huidan Zhao ◽

Hong Ding ◽

Jianping Tan ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Polycystic Ovary Syndrome ◽

Gestational Diabetes Mellitus ◽

Ovarian Stimulation ◽

Polycystic Ovary ◽

Pregnancy Induced Hypertension ◽

Ovary Syndrome ◽

Induced Hypertension ◽

Ivf Et

Objectives. To evaluate pregnancy outcomes and its determinants in women with polycystic ovary syndrome (PCOS).Methods. Two-hundred and twenty pregnant PCOS and 594 healthy women were followed from early pregnancy. Incidences of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preterm birth, twinning, and fetal growth restriction (FGR) were determined.Results. The incidence of GDM was notably higher among all PCOS combined (54.9%; OR: 2.9, 95% CI: 2.0–4.1) and PCOS subgroups, whether they conceived spontaneously (51.5%; OR: 3.3, 95% CI: 2.0–5.4), or via IVF-ET or ovarian stimulation, compared with controls (14.3%;P<0.001). The incidence of PIH was also higher among all PCOS (10.4%; OR: 2.2, 95% CI: 1.1–4.4) and the subgroup conceiving spontaneously (11.8%; OR: 2.6, 95% CI: 1.1–6.2;P<0.001) but not for those conceiving with IVF-ET (9.1%) or ovarian stimulation (9.4%). Lean women with PCOS (BMI<24kg/m2) had higher incidences of GDM (51.1% versus 14.5%; OR: 5.6, 95% CI: 3.4–9.0) and PIH (8.9% versus 3.2%; OR: 3.0, 95% CI: 1.3–7.1) than lean controls. PCOS woemn with normal glucose tolerance had higher risk for PIH than their comparable control group (OR: 4.0, 95% CI: 1.3–11.7).Conclusion. This study suggested that PCOS is an independent risk factor for the development of GDM and PIH. This trial is registered withChiCTR-RCC-11001824.

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Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis

Gynecological Endocrinology ◽

10.3109/09513590.2015.1041906 ◽

2015 ◽

Vol 31 (11) ◽

pp. 833-839 ◽

Cited By ~ 24

Author(s):

Li Feng ◽

Xiao-Fang Lin ◽

Zhi-Hua Wan ◽

Dan Hu ◽

Yu-Kai Du

Keyword(s):

Polycystic Ovary Syndrome ◽

Pregnancy Complications ◽

Polycystic Ovary ◽

Meta Analysis ◽

Ovary Syndrome

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Metformin therapy before conception versus throughout the pregnancy and risk of gestational diabetes mellitus in women with polycystic ovary syndrome: a systemic review, meta-analysis and meta-regression

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-019-0453-7 ◽

2019 ◽

Vol 11 (1) ◽

Cited By ~ 3

Author(s):

Razieh Bidhendi Yarandi ◽

Samira Behboudi-Gandevani ◽

Mina Amiri ◽

Fahimeh Ramezani Tehrani

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Polycystic Ovary Syndrome ◽

Gestational Diabetes Mellitus ◽

Polycystic Ovary ◽

Meta Analysis ◽

Systemic Review ◽

Ovary Syndrome ◽

Metformin Therapy ◽

Meta Regression

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Increased maternal pregnancy complications in polycystic ovary syndrome appear to be independent of obesity—A systematic review, meta‐analysis, and meta‐regression

Obesity Reviews ◽

10.1111/obr.12829 ◽

2019 ◽

Vol 20 (5) ◽

pp. 659-674 ◽

Cited By ~ 22

Author(s):

Mahnaz Bahri Khomami ◽

Anju E. Joham ◽

Jacqueline A. Boyle ◽

Terhi Piltonen ◽

Michael Silagy ◽

...

Keyword(s):

Systematic Review ◽

Polycystic Ovary Syndrome ◽

Pregnancy Complications ◽

Polycystic Ovary ◽

Meta Analysis ◽

Ovary Syndrome ◽

Meta Regression

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Effect of Metformin Intervention during Pregnancy on the Gestational Diabetes Mellitus in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Journal of Diabetes Research ◽

10.1155/2014/381231 ◽

2014 ◽

Vol 2014 ◽

pp. 1-13 ◽

Cited By ~ 27

Author(s):

Zhihong Zhuo ◽

Aiming Wang ◽

Huimin Yu

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Polycystic Ovary Syndrome ◽

Gestational Diabetes Mellitus ◽

Polycystic Ovary ◽

Meta Analysis ◽

Fixed Effect Model ◽

Ovary Syndrome ◽

Insulin Sensitizer ◽

Functional Consequences

Metformin is an effective insulin sensitizer treating type 2 diabetes mellitus. However, the functional consequences of metformin administration throughout pregnancy on gestational diabetes mellitus (GDM) with polycystic ovary syndrome (PCOS) have not been assessed. We therefore performed a meta-analysis and system review to determine the effect of metformin on GDM in PCOS. A meta-analysis was performed on the published studies before December, 2013. Meta-analysis examined whether metformin could reduce GDM occurrence in PCOS with a fixed effect model. The odds ratio (OR) with 95% confidence interval (95% CI) was calculated to estimate the strength of association. A total of 13 studies including 5 RCTs and 8 non-RCTs were enrolled. Ultimately, effectiveness analysis demonstrated that, in total, there was no significant availability of metformin on GDM in PCOS in contrast to placebo (OR = 1.07, 95% CI 0.60–1.92) in RCTs and significant availability of metformin on GDM (OR = 0.19, 95% CI 0.13–0.27) was indicated in non-RCTs. In summary, according to the results of our meta-analysis, strictly, metformin did not significantly effect on GDM with PCOS, though more multicenters RCTs still need to be investigated.

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Maternal and neonatal outcomes among pregnant women with different polycystic ovary syndrome phenotypes: A cross-sectional study

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v13i5.7154 ◽

2020 ◽

Author(s):

Akramsadat Dehghani Firoozabadi ◽

Razieh Dehghani Firouzabadi ◽

Maryam Eftekhar ◽

Afsar Sadat Tabatabaei Bafghi ◽

Farimah Shamsi

Keyword(s):

Gestational Diabetes ◽

Polycystic Ovary Syndrome ◽

Pregnant Women ◽

Polycystic Ovary ◽

Cross Sectional Study ◽

Neonatal Outcomes ◽

Pregnancy Induced Hypertension ◽

Ovary Syndrome ◽

Cross Sectional ◽

Induced Hypertension

Background: Pregnancy is a process associated with various metabolic and hormonal changes, and polycystic ovary syndrome (PCOS) can affect this process. Objective: This study aimed to evaluate and compare the maternal and neonatal outcomes among pregnant women with different polycystic ovary syndrome phenotypes. Materials and Methods: In this cross-sectional study, 200 pregnant women with PCOS according to the 2003 ESHRE/ASRM criteria were categorized into four phenotype groups (A-D). The maternal outcomes include gestational diabetes mellitus, pregnancy-induced hypertension, premature rupture of membranes, preterm labor, small-for-gestational age birth, intrauterine growth restriction, intrauterine mortality, preeclampsia, abortion, amniotic fluid disorders, delivery method, and cause of cesarean section were studied between groups. Additionally, neonatal outcomes such as neonatal weight, neonatal recovery, 5-min Apgar score, neonatal icter, the need for NICU admission, the cause of hospitalization, and infant mortality rate were investigated and compared among the groups. Results: According to the results, phenotype D (37%) was the most common phenotype among the participants. The risk of gestational diabetes was more common in phenotype A than in the other phenotypes, whereas pregnancy-induced hypertension was most common in phenotype B. No significant differences were observed in the neonatal complications among the PCOS phenotypes. Conclusion: Considering the higher risk of gestational diabetes mellitus and pregnancy-induced hypertension in PCOS phenotypes A and B, women with these phenotypes need more precise prenatal care. Key words: Pregnancy outcome, Polycystic ovary syndrome, Phenotype, Pregnancy.

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Fish Oil Supplementation does not Reduce Risks of Gestational Diabetes Mellitus, Pregnancy-Induced Hypertension, or Pre-Eclampsia: A Meta-Analysis of Randomized Controlled Trials

Medical Science Monitor ◽

10.12659/msm.894033 ◽

2015 ◽

Vol 21 ◽

pp. 2322-2330 ◽

Cited By ~ 8

Author(s):

Bing Chen ◽

Xinran Ji ◽

Lei Zhang ◽

Zhaohui Hou ◽

Chundong Li ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Randomized Controlled Trials ◽

Meta Analysis ◽

Controlled Trials ◽

Pregnancy Induced Hypertension ◽

Randomized Controlled ◽

Induced Hypertension ◽

Fish Oil Supplementation

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Meta-Analysis Finds Use of Inhaled Corticosteroids During Pregnancy Safe: A Systematic Meta-Analysis Review

Human & Experimental Toxicology ◽

10.1191/0960327106het647oa ◽

2006 ◽

Vol 25 (8) ◽

pp. 447-452 ◽

Cited By ~ 39

Author(s):

R Rahimi ◽

S Nikfar ◽

M Abdollahi

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Inhaled Corticosteroids ◽

Birth Outcome ◽

Meta Analysis ◽

Perinatal Outcomes ◽

Pregnancy Induced Hypertension ◽

Drug Of Choice ◽

Term Delivery ◽

Induced Hypertension

Inhaled corticosteroids (ICs) are the drug of choice for asthmatic women during pregnancy, but the results on the effects of these medications on obstetrical and perinatal outcomes are not conclusive. Meta-analysis is the statistical analysis of a collection of analysis results from individual studies for the purpose of integrating the findings. Meta-analysis techniques are necessary because only summary statistics are available in the literature. In order to determine the risk of exposure to ICs, we pooled data from all clinical studies that evaluated the pregnancy and perinatal outcomes in women exposed to this group of drugs during pregnancy by the meta-analytic technique. PUBMED, OVID, EMBASE and SCOPUS databases were searched for studies that investigated birth outcome following exposure to ICs during pregnancy. Data were collected from 1997 to 2005 (up to 31 December). Types of outcome investigated were major malformations, pre-term delivery, low birth weight and pregnancy-induced hypertension. The criteria for inclusion of studies in this meta-analysis were exposure of women to any therapeutic dosage of any ICs (fluticasone, beclomethasone, budesonide, triamcinolone and flunisolide) during pregnancy. The results showed that ICs do not increase the risk of major malformations, preterm delivery, low birth weight and pregnancy-induced hypertension. In conclusion, ICs do not increase the rates of any obstetrical outcomes investigated in the present study and interestingly improve the symptoms and are helpful in the management of asthma and thus can be used comfortably during pregnancy.

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Study on the influence of pregnancy-induced hypertension on neonatal birth weight

Journal of Investigative Medicine ◽

10.1136/jim-2017-000626 ◽

2018 ◽

Vol 66 (6) ◽

pp. 1008-1014 ◽

Cited By ~ 2

Author(s):

Fangliang Lei ◽

Danmeng Liu ◽

Yuan Shen ◽

Lili Zhang ◽

Shanshan Li ◽

...

Keyword(s):

Birth Weight ◽

Healthcare Professional ◽

Pregnant Women ◽

Cross Sectional Study ◽

Shaanxi Province ◽

Pregnancy Induced Hypertension ◽

Sectional Study ◽

Cross Sectional ◽

Neonatal Birth Weight ◽

Induced Hypertension

To explore the effect of pregnancy-induced hypertension (PIH) on neonatal birth weight and provide the necessary reference value for the maternal and children health service. A cross-sectional study was carried out in Shaanxi Province of China in 2013. And a total of 28 045 singleton live infants and their mothers were recruited using a stratified, multistage, probability-proportional-to-size sampling method. Among the 28 045 women of childbearing age surveyed, multiple linear regression and quantile regression analysis all showed that the birth weight of newborns whose mothers had suffered from PIH during pregnancy was significantly lower than those whose mothers had not suffered from PIH during pregnancy from very low to higher birth weight percentiles (q=0–0.85), an average decrease of 137.45 g (β=−137.45, t=−5.77 and p<0.001). When birth weight was at q=0.90–1.00 percentiles, there was no birth weight difference between two groups. The present cross-sectional study indicated that PIH had an effect of on neonatal birth weight. When pregnant women with PIH are identified then the healthcare professional initiates a closer supervision of their pregnancy in order to ameliorate the status of BP and provide a good intrauterine environment for the fetus. In addition, the gynecologists should admonish the pregnant women that their health is related to the health of their fetus, then gravidas may be more engaged to alert their physician and accept early or preventative interventions. And the healthcare professional should ask and be alert to the issues of hypertension during pregnancy.

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