scholarly journals Correlation of HPV-DNA Test with Cytology and Histology for the Diagnosis of Cervical Cancer and Precancerous Lesions in a Tertiary Care Hospital in Bangladesh

2017 ◽  
Vol 13 (1) ◽  
pp. 103-105
Author(s):  
Shamina Islam ◽  
Md Nizam Uddin ◽  
Nasima Akter ◽  
Tarana Tabashum ◽  
Maznun Us Sadakin ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Pap Smear ◽  
Precancerous Lesion ◽  
Care Hospital ◽  
Hybrid Capture ◽  
Dna Test ◽  
Hpv Dna ◽  
Cancerous Lesion ◽  
Hybrid Capture 2 ◽  
Hpv Dna Test

Introduction: Cervical cancer is the second most prevalent cancer among women worldwide. High-Risk Human Papilloma virus (hr-HPV) is an established cause of cervical cancer and precancerous lesion. Studies have shown the relationship between the HPV-DNA test with cervical precancerous and cancerous lesion in diagnosing cervical cancer. This study aimed to correlate HPV-DNA test with both cytology and histology. Objective: To find out the correlation of HPV-DNA test with cytology and histology for the diagnosis of cervical precancerous and cancerous lesion. Materials and Methods: Cervical smears and DNA samples were collected from the selected patients attending the colposcopy clinic of Bangabandhu Sheikh Mujib Medical University (BSMMU) from July 2011 to April 2013. Biopsy was done on colposcopically positive cases and histopathology reports were obtained. Thus 99 histologically proven patients of cervical cancer and precancerous lesion were selected. Pap smear was carried out on these 99 patients. HPV-DNA test (Hybrid Capture-2 assay) was carried out on the same samples and viral loads were estimated. Results: Among the 99 cases, 28(28.28%) cases were positive with Hybrid Capture-2(HC-2) assay. Out of 60 cases of CIN-I (Cervical Intraepithelial Neoplasia-1), 7(11.7%) cases were positive with HC-2. Among others, 3(15.0%) cases of CIN-II were positive with HC-2. The viral load was very high in invasive SCC (squamous cell carcinoma) cases in contrast to other categories of histological and cytological diagnosis. A significant relationship was observed between HC-2 and histological diagnosis (P<0.005); and between HC-2 and Pap smear (P<0.005). Conclusion: Introduction of HC-2 where possible along with Pap smear would be highly effective in primary screening and subsequent follow up of cervical precancerous and cancerous lesion. Journal of Armed Forces Medical College Bangladesh Vol.13(1) 2017: 103-105

scholarly journals Efficiency of the Hybrid Capture 2 HPV DNA Test in Cervical Cancer Screening

2003 ◽  
Vol 120 (4) ◽  
pp. 492-499 ◽  
Author(s):  
Patricia de Cremoux ◽  
Joël Coste ◽  
Xavier Sastre-Garau ◽  
Martine Thioux ◽  
Christelle Bouillac ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Hybrid Capture ◽  
Dna Test ◽  
Hpv Dna ◽  
Hybrid Capture 2 ◽  
Hpv Dna Test

scholarly journals Efficiency of HPV DNA Test versus Pap Smear in the Screening of Cervical Cancer

2018 ◽  
Vol 1 (2) ◽  
pp. 9-13
Author(s):  
Renee Pradhan ◽  
U. Pant ◽  
B. Aryal
Keyword(s):  
Cervical Cancer ◽  
Cervical Intraepithelial Neoplasia ◽  
Pap Smear ◽  
Intraepithelial Neoplasia ◽  
Cervical Neoplasia ◽  
Hpv Testing ◽  
Dna Test ◽  
Hpv Dna ◽  
Smear Testing ◽  
Hpv Dna Test

Introduction: Cancer cervix is a common genital cancer. Human papillomavirus is the main cause of cervical cancer because of the strong association of certain HPV genotypes and the development of cervical cancer and its precursor lesions, cervical intraepithelial neoplasia CIN 2 or CIN3. Methods: The study was conducted on 180 gynecological patients seen at the outpatient department of Manipal Hospital, Bangalore. A comparative study of HPV DNA test with Pap smear in the screening of cervical neoplasia was carried out over the period of 24 months from August 2011 to June 2013. Results: The incidence of cervical cancer and its associated mortality has declined in recent years, largely due to the widespread implementation of screening programs by Pap smear testing. The management and the prevention of cervical cancer should change with HPV DNA testing for high risk HPV, which is more sensitive than pap smear testing. Infection of cervix with HPV is necessary to cause cervical neoplasia and cervical cancer. Persistent infection with HPV is required for the development of cervical dysplasia and invasive cervical cancer. Conclusions: HPV testing alone for primary screening appears promising in women aged 30 years and older as this group is at greatest risk of developing CIN 3. As compared with Pap testing, HPV testing has greater sensitivity for detection of cervical intraepithelial neoplasia.

Hybrid Capture System HPV DNA Test as a Screening Tool of Cervical Cancer

2001 ◽  
Vol 12 (1) ◽  
pp. 31 ◽  
Author(s):  
Jung Ho Shin ◽  
Jae Kwan Lee ◽  
Soo Yong Chough ◽  
Jun Young Hur ◽  
Yong Kyun Park ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Screening Tool ◽  
Hybrid Capture ◽  
Dna Test ◽  
Hpv Dna ◽  
Hpv Dna Test
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