scholarly journals Efficiency of HPV DNA Test versus Pap Smear in the Screening of Cervical Cancer

2018 ◽  
Vol 1 (2) ◽  
pp. 9-13
Author(s):  
Renee Pradhan ◽  
U. Pant ◽  
B. Aryal
Keyword(s):  
Cervical Cancer ◽  
Cervical Intraepithelial Neoplasia ◽  
Pap Smear ◽  
Intraepithelial Neoplasia ◽  
Cervical Neoplasia ◽  
Hpv Testing ◽  
Dna Test ◽  
Hpv Dna ◽  
Smear Testing ◽  
Hpv Dna Test

Introduction: Cancer cervix is a common genital cancer. Human papillomavirus is the main cause of cervical cancer because of the strong association of certain HPV genotypes and the development of cervical cancer and its precursor lesions, cervical intraepithelial neoplasia CIN 2 or CIN3. Methods: The study was conducted on 180 gynecological patients seen at the outpatient department of Manipal Hospital, Bangalore. A comparative study of HPV DNA test with Pap smear in the screening of cervical neoplasia was carried out over the period of 24 months from August 2011 to June 2013. Results: The incidence of cervical cancer and its associated mortality has declined in recent years, largely due to the widespread implementation of screening programs by Pap smear testing. The management and the prevention of cervical cancer should change with HPV DNA testing for high risk HPV, which is more sensitive than pap smear testing. Infection of cervix with HPV is necessary to cause cervical neoplasia and cervical cancer. Persistent infection with HPV is required for the development of cervical dysplasia and invasive cervical cancer. Conclusions: HPV testing alone for primary screening appears promising in women aged 30 years and older as this group is at greatest risk of developing CIN 3. As compared with Pap testing, HPV testing has greater sensitivity for detection of cervical intraepithelial neoplasia.

scholarly journals Role of the HPV DNA Test in Follow-up of Treated Cervical Intraepithelial Neoplasia in Bangladesh

2014 ◽  
Vol 15 (19) ◽  
pp. 8063-8067 ◽  
Author(s):  
Ashrafun Nessa ◽  
Mohammad Harun Ur Rashid ◽  
Munira Jahan ◽  
Noor-E Ferdous ◽  
Pervin Akhter Shamsun Nahar ◽  
...  
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
Dna Test ◽  
Hpv Dna ◽  
Hpv Dna Test

scholarly journals Correlation of HPV-DNA Test with Cytology and Histology for the Diagnosis of Cervical Cancer and Precancerous Lesions in a Tertiary Care Hospital in Bangladesh

2017 ◽  
Vol 13 (1) ◽  
pp. 103-105
Author(s):  
Shamina Islam ◽  
Md Nizam Uddin ◽  
Nasima Akter ◽  
Tarana Tabashum ◽  
Maznun Us Sadakin ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Pap Smear ◽  
Precancerous Lesion ◽  
Care Hospital ◽  
Hybrid Capture ◽  
Dna Test ◽  
Hpv Dna ◽  
Cancerous Lesion ◽  
Hybrid Capture 2 ◽  
Hpv Dna Test

Introduction: Cervical cancer is the second most prevalent cancer among women worldwide. High-Risk Human Papilloma virus (hr-HPV) is an established cause of cervical cancer and precancerous lesion. Studies have shown the relationship between the HPV-DNA test with cervical precancerous and cancerous lesion in diagnosing cervical cancer. This study aimed to correlate HPV-DNA test with both cytology and histology. Objective: To find out the correlation of HPV-DNA test with cytology and histology for the diagnosis of cervical precancerous and cancerous lesion. Materials and Methods: Cervical smears and DNA samples were collected from the selected patients attending the colposcopy clinic of Bangabandhu Sheikh Mujib Medical University (BSMMU) from July 2011 to April 2013. Biopsy was done on colposcopically positive cases and histopathology reports were obtained. Thus 99 histologically proven patients of cervical cancer and precancerous lesion were selected. Pap smear was carried out on these 99 patients. HPV-DNA test (Hybrid Capture-2 assay) was carried out on the same samples and viral loads were estimated. Results: Among the 99 cases, 28(28.28%) cases were positive with Hybrid Capture-2(HC-2) assay. Out of 60 cases of CIN-I (Cervical Intraepithelial Neoplasia-1), 7(11.7%) cases were positive with HC-2. Among others, 3(15.0%) cases of CIN-II were positive with HC-2. The viral load was very high in invasive SCC (squamous cell carcinoma) cases in contrast to other categories of histological and cytological diagnosis. A significant relationship was observed between HC-2 and histological diagnosis (P<0.005); and between HC-2 and Pap smear (P<0.005). Conclusion: Introduction of HC-2 where possible along with Pap smear would be highly effective in primary screening and subsequent follow up of cervical precancerous and cancerous lesion. Journal of Armed Forces Medical College Bangladesh Vol.13(1) 2017: 103-105

scholarly journals The outcome of colposcopy in women attending with persistent postcoital bleeding and negative HPV-DNA test

2021 ◽  
Vol 8 (2) ◽  
pp. 97-100
Author(s):  
Mehmet Bayrak ◽  
Hakan Ozan
Keyword(s):  
Pap Smear ◽  
Cervical Dysplasia ◽  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Dna Test ◽  
Hpv Dna ◽  
Pap Smear Test ◽  
Smear Test ◽  
Hpv Dna Test ◽  
Postcoital Bleeding

Objective: Women with postcoital bleeding (PCB) are recommended to be evaluated by colposcopy even if cytology is negative. Human papillomavirus (HPV) testing increases the detection of cervical intraepithelial neoplasia or worse compared to the Pap smear test. We aimed to determine the incidence of cervical pathology among women with persistent PCB with a negative Pap smear or HPV-DNA test. Our study, therefore, questions the place of HPV DNA test in women with PCB. Material and Methods: The clinical data of 212 women with persistent PCB and negative cytology or negative HPV DNA test referred to colposcopy, between January 2010 and June 2019, were retrospectively evaluated. Results: Among the 212 PCB patients, 161 (75.9%) were cytology negative and 51 (24.1%) were HPV DNA test (n=40) or co-test (n=11)  (negative for HPV DNA test and cytology) negative. There were no cases of invasive cancer. The women referred with negative cytology were more likely than those with negative HPV DNA to have CIN (21/161 (13%),  1/51 (1.9%) p=0.042. Seven women (4.3%) were diagnosed with high-grade cervical dysplasia in the negative cytology group. None of the patients in the HPV DNA negative group was diagnosed with high-grade cervical dysplasia. Conclusion: Our data show that a normal Pap smear cytology in women with PCB does not rule out the possibility of  HSIL. HPV DNA testing is a useful triage test to determine if colposcopy referral is required in the context of post-coital bleeding with negative smear test.

Combined Pap Smear, Cervicography and HPV DNA Testing in the Detection of Cervical Intraepithelial Neoplasia and Cancer

2000 ◽  
Vol 44 (3) ◽  
pp. 310-318 ◽  
Author(s):  
Silvano Costa ◽  
Mario Sideri ◽  
Kari Syrjänen ◽  
Patrizia Terzano ◽  
Maria De Nuzzo ◽  
...  
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Pap Smear ◽  
Intraepithelial Neoplasia ◽  
Dna Testing ◽  
Hpv Dna ◽  
Hpv Dna Testing

STUDY OF EXPRESSION OF BCL-2 MARKER IN PREMALIGNANT LESIONS OF CERVICAL CANCER

2021 ◽  
pp. 46-47
Author(s):  
Bhubaneswar Saikia ◽  
Tulika Thakuria.
Keyword(s):  
Cervical Cancer ◽  
Apoptotic Cell ◽  
Intraepithelial Neoplasia ◽  
Premalignant Lesions ◽  
Dna Test ◽  
Hpv Dna ◽  
Medical College ◽  
Proliferation And Apoptosis ◽  
Incident Cases

Background: Cervical cancer is one of the common cancers in women of developing countries. Persistent human papilloma virus (HPV) is probably the best predictor of cervical carcinogenesis, but HPV DNA test being costlier expression of certain markers of cell proliferation and apoptosis have been studied. The present study was conducted to evaluate the expression of bcl-2 in premalignant lesions of uterine cervix. Methods: Specimens of cervical biopsy retrieved from incident cases for routine histopathological evaluation from the Department of Obstetrics and Gynaecology, Gauhati Medical College and Hospital, Guwahati, India formed the source of data. Results: A total of 40 cases were studied in the present study comprising of 23 cases of Cervical intraepithelial neoplasia (CIN) 1, 9 cases of CIN 2, 6 cases of CIN 3, and 2 cases of Carcinoma in situ (CIS). It was observed that there was increase in bcl-2 positivity with increasing grade of CIN (CIN 1=69.57%, CIN 2=77.78%, CIN 3=83.33%, CIS=100%). Conclusions: Bcl-2 being an intracellular membrane protein prevents apoptotic cell death. Hence, bcl-2 can be used as a biomarker to know the severity of the premalignant lesions. Thus, it may also help in identifying the high risk premalignant lesions which needs further surveillance and treatment

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