scholarly journals Relationship of serum ionized calcium and magnesium concentration with parasympathetic nerve Function in type 2 diabetes mellitus

2016 ◽  
Vol 11 (2) ◽  
pp. 70-73
Author(s):  
Md Khairul Alam ◽  
Noorzahan Begum ◽  
Shelina Begum
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ionized Calcium ◽  
Magnesium Concentration ◽  
Nerve Function ◽  
Parasympathetic Nerve ◽  
Serum Ionized Calcium ◽  
Calcium And Magnesium

Background: Changes in serum Ca2+ and Mg2+ level may have some relationship to the occurrence of autonomic neuropathy in diabetes.Objective: To observe relationship between parasympathetic nerve function and serum ionized calcium & magnesium in type 2 diabetes mellitus (T2DM).Methods: This cross sectional study was carried out in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka on 47 T2DM patients aged 40-68 years of both sexes. Twenty five patients were recently diagnosed diabetics (RDM) and 22 were long term diabetics (LDM) with 10-20 years duration of diabetes. Parasympathetic nerve functions of all patients were assessed by three simple non-invasive cardiovascular reflex tests. Ionized serum calcium and magnesium were measured by ion sensitive electrode method using NOVA electrode. Data were analyzed by unpaired‘t’test and Pearson’s correlation co-efficient test.Results: Serum ionized calcium and magnesium levels were significantly higher in RDM (P<0.001) and LDM (P<0.001) compared to healthy control. On correlation analysis, significant negative correlation of parasympathetic nerve function with Mg2+was found in both RDM and LDM patients.Conclusion: The result of this study concluded that higher calcium and magnesium ion may be associated with type 2 diabetes and parasympathetic nerve function of diabetic patients may have inverse relationship to serum Mg2+.Bangladesh Soc Physiol. 2016, December; 11(2): 70-73

scholarly journals Effect of Deep Relaxation Technique on Cardiac Autonomic Dysfunction in Type 2 Diabetes Mellitus

2018 ◽  
Vol 13 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Farhana Rahman ◽  
Sultana Ferdousi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Heart Rate ◽  
Type 2 Diabetes Mellitus ◽  
Autonomic Dysfunction ◽  
Time Domain ◽  
Autonomic Nerve ◽  
Nerve Function ◽  
Autonomic Nerve Function

Background: Type 2 Diabetes Mellitus (T2DM) may be associated with autonomic dysfunction. Performance of deep relaxation technique (DRT) may cause upturn of this deranged nerve function.Objective: To evaluate the impact of DRT on cardiac autonomic nerve function by analysis of time domain series of Heart Rate Variability (HRV) in T2DM patients.Methods: This prospective study was carried out on 30 female T2DM patients aged 50-55 years with duration of diabetes of 5-10 years enrolled from the Out Patient Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka. They performed DRT (20 minutes twice daily) for 3 months. Thirty apparently healthy female with similar age who did not perform DRT or any other form of exercise, were included as control. To assess the cardiac autonomic nerve function, time domain measures of HRV of all subjects were recorded by a data acquisition device Power Lab (Australia). HRV data of all subjects were collected at baseline (pre) and also after 3 months(Post). For statistical analysis, paired and independent sample t-test were used.Results: The pre-intervention values of resting HR was significantly higher (p<0.001) and mean R-R interval, SDRR, CVRR, SDSD, RMSSD and pRR50% were significantly lower (p<0.001) in all diabetic patients compared to control. After 3 months of DRT, there was significant decrement in resting mean heart rate (p<0.01) and significant increment in mean R-R interval, SDRR, CVRR, SDSD, RMSSD and pRR50% (p<0.001) compared to their pre-intervention values.Conclusion: Cardiac autonomic nerve dysfunction may occur in T2DM and 3 months regular practice of DRT mayy significantly improv cardiac autonomic nerve function with parasympathetic dominance.J Bangladesh Soc Physiol. 2018, June; 13(1): 22-28

scholarly journals Intakes of Zinc, Potassium, Calcium, and Magnesium of Individuals with Type 2 Diabetes Mellitus and the Relationship with Glycemic Control

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1948 ◽  
Author(s):  
Paula Brandão-Lima ◽  
Gabrielli Carvalho ◽  
Ramara Santos ◽  
Beatriz Santos ◽  
Natalia Dias-Vasconcelos ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Binary Logistic Regression ◽  
Binary Logistic Regression Analysis ◽  
Micronutrient Intake ◽  
Calcium And Magnesium ◽  
The Relationship

The role of the concomitant intake of zinc, potassium, calcium, and magnesium in the glycemic control of individuals with type 2 diabetes mellitus (T2DM) has not been extensively discussed. We evaluated the relationship between the dietary intake of these micronutrients and glycemic markers in 95 individuals with T2DM (mean age 48.6 ± 8.4 years). Hierarchical grouping analysis was used to divide the individuals into two clusters according to their micronutrient intake, and differences between clusters were statistically assessed. Effects of individual and combination intake of micronutrients on glycated hemoglobin percentage (%HbA1c) were assessed using multiple linear regression and binary logistic regression analysis. We observed a high likelihood of inadequate intake of the four micronutrients. The group with lower micronutrient intake (cluster 1) displayed higher %HbA1c (p = 0.006) and triglyceride (p = 0.010) levels. High %HbA1c showed an association with cluster 1 (odds ratio (OR) = 3.041, 95% confidence interval (CI) = 1.131; 8.175) and time of T2DM diagnosis (OR = 1.155, 95% CI = 1.043; 1.278). Potassium (β = −0.001, p = 0.017) and magnesium (β = −0.007, p = 0.015) intakes were inversely associated with %HbA1c. Reduced concomitant intake of the four micronutrients studied proved to be associated with risk of increased %HbA1c in individuals with T2DM, which was particularly predicted by magnesium and potassium intakes.

Relationship Between AST/ALT Ratio and Peripheral Nerve Function in Type 2 Diabetes Mellitus

Nano LIFE ◽  
2020 ◽  
Vol 10 (01n02) ◽  
pp. 2040004 ◽  
Author(s):  
Yinan Zhang ◽  
Lizhi Zhang ◽  
Fengwen Li ◽  
Bo Liu ◽  
Chen Chu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Nerve ◽  
Liver Enzymes ◽  
Nerve Function ◽  
Peripheral Nerve Function ◽  
Glutamyl Transferase ◽  
Group 1

Background: The aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio is suggested to be related to the increased risks of many metabolic diseases, whereas its association with neurological function in type 2 diabetes mellitus (T2DM) has not been understood. In this study, we aim to investigate the relationships between serum liver enzymes (ALT, AST, the AST/ALT ratio, gamma-glutamyl transferase (GGT)) and peripheral nerve function in patients with T2DM. Methods: In Group 1, we analyzed the associations between parameters of nerve function and liver enzymes in 460 T2DM patients from rural area of Shanghai. Besides, the same methods were applied to another group of 828 T2DM subjects from urban area of Shanghai. Results: In Group 1, the AST/ALT ratio was significantly higher in patients with abnormal nerve conduction [Formula: see text]. The peripheral nerve function significantly declined with increasing tertiles of AST/ALT ratio ([Formula: see text]). After adjustment for all potential confounders, the ratio of AST/ALT was still negatively correlated with the composite Z-scores of conduction velocity (CV). In Group 2, similar significant associations were found between the AST/ALT ratio and peripheral nerve function after adjustment for covariates. Conclusions: In two independent T2DM populations, the AST/ALT ratio was independently and consistently related to peripheral nerve function. The AST/ALT ratio might be helpful to highlight T2DM patients at high risk for diabetic peripheral neuropathy.

scholarly journals Influence of Risk Factors and Diabetic Complications on Peripheral Nerve Function in Type 2 Diabetes Mellitus

2015 ◽  
Vol 61 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Bălașa Rodica ◽  
Z. Bajko ◽  
Smaranda Maier ◽  
S. Voidăzan ◽  
Anca Moțățăianu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycaemic Control ◽  
Peripheral Nerve ◽  
Sural Nerve ◽  
Sensory Nerve ◽  
Nerve Function ◽  
Peripheral Nerve Function

Abstract Objective: The aim of this study was to evaluate the impact of age, diabetes duration, glycaemic control, existence of cardiac autonomic neuropathy (CAN), retinopathy and of macroangiopathy on the peripheral nerve function in patients with type 2 diabetes. Methods: One hundred forty-nine type 2 diabetes mellitus patients were assessed with peripheral motor and sensory nerve conduction tests and cardiovascular reflex tests, as well as being evaluated for retinopathy, common carotid artery intimal-media-thickness (IMT) and anklebrachial index (ABI). Results: The duration of diabetes has the strongest effect in the reduction of the amplitude of motor response in the peroneal nerve and of the sensory amplitude in the sural nerve. The strongest correlations were found between glycaemic control and decreasing motor amplitude in the median nerve and sensory amplitude in the sural nerve, respectively. The motor and sensory nerve action potential amplitudes were significantly affected in the group of patients with CAN. According to multivariate logistic regression analysis, duration of diabetes and presence of CAN were the most important factors that influenced the motor and sensory nerve function. Conclusion: The presence of CAN together with diabetes duration and poor glycaemic control were associated with impaired peripheral nerve function, while macroangiopathy does not seem to be associated with the impairment of these electrophysiological parameters.

The study of new biomarkers of bone metabolism of sclerostin and cathepsin K in patients with type 2 diabetes mellitus

2019 ◽  
Vol 64 (6) ◽  
pp. 363-370
Author(s):  
Guzel M. Nurullina ◽  
Guzyal I. Akhmadullina
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Bone Metabolism ◽  
Cathepsin K ◽  
Ionized Calcium ◽  
Mineral Density ◽  
25 Oh Vitamin D

BACKGROUND: Deterioration of bone tissue in type 2 diabetes mellitus (T2D): lead to the increased bone brittleness and to higher risk of low-energy fractures. AIM: to study serum levels of sclerostin and cathepsin K in assessing bone metabolism in patients with type 2 diabetes mellitus. MATERIAL AND METHODS: 102 postmenopausal women aged from 46 to 67 years were examined. All patients were divided into 4 groups: the first group included 39 patients with type 2 diabetes (T2DM) and postmenopausal osteoporosis (PO), the second group — 25 patients with PO without T2DM, the third group included 21 patients with T2DM but without PO, and the fourth group (control) — 17 people. Patinets of all groups were tested for ionized calcium, phosphorus, total alkaline phosphatase (ALP), parathyroid hormone, 25 (OH) vitamin D, bone mineral density in groups I, II, and IV, levels of sclerostin and cathepsin Kin seru, were also obtained. RESULTS: No statistically significant differences have been observed between groups in sclerostin levels, a positive correlation was found between sclerostin and НbА1с (r=0.43; p=0.009) in the group of patients with T2DM and PO, a negative correlation was found between sclerostin and ionized calcium (r=–0.45; p=0.037) in the group of patients with PO. Cathepsin C in the first group was lower than in the second group (p=0.046), but taking into account Bonferroni correction this difference was not statistically significant. In the first and third groups, 25 (OH) vitamin D was lower than in the groups without T2D. The ALP negatively correlated with the duration of the postmenopause (r=–0.39 and r=–0.64; р=0.05, respectively). CONCLUSIONS: Cathepsin С was lower in patients with T2DM2 and PO, which may indirectly indicate a decreased bone resorption. Concentration of sclerostin, which plays a key role in the mechanism of inhibiting osteoblastogenesis, positively correlated with НbА1с.

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