scholarly journals Recurrent Toxoplasma Retinitis Treated with Long-Term Oral Antibiotics

2021 ◽  
Vol 62 (11) ◽  
pp. 1565-1569
Author(s):  
Hosuck Yeom ◽  
Seung Hun Park ◽  
Heeyoon Cho ◽  
Yong Un Shin
Keyword(s):  
Visual Acuity ◽  
Low Dose ◽  
Oral Antibiotics ◽  
Vitreous Opacity ◽  
Oral Steroids ◽  
Dose Oral ◽  
Retinal Inflammation ◽  
The Right ◽  
Intravitreal Dexamethasone

Purpose: The purpose of this case was to report the inhibition of toxoplasma retinitis reactivation with long-term, low-dose antibiotics.Case summary: A 76-year-old woman complained of poor vision and floaters in her right eye. The corrected visual acuity (LogMAR) of the right eye was 0.5, and there was an area of yellow infiltration and dye leakage on the retinal fluorescein angiography images. Toxoplasma IgG were detected in the serum, the patient was diagnosed with toxoplasma retinitis, and the patient was advised oral trimethoprim-sulfamethoxazole, clindamycin, and steroids. Her visual acuity improved and the inflammation resolved. However, she again had decreased visual activity and retinal inflammation in her right eye after 5 months. The inflammation improved with oral steroids, but she was shifted to intravitreal dexamethasone because of the side effects of systemic steroids. Although the inflammation improved initially, there was worsening of inflammation (evidenced by vitreous opacity) after 2 months, which was treated with oral antibiotics. After vitrectomy for the removal of residual vitreous opacity, antibiotics were stopped because of the stable disease course. After discontinuation of the antibiotics, inflammation was noted again, and low-dose trimethoprim-sulfamethoxazole was administered. Low-dose antibiotics were continued for 5 months and the disease remained stable without any retinal inflammation.Conclusions: Long-term, low-dose oral antibiotics may prevent reactivation of recurrent toxoplasma retinitis.

Amelioration of flulike symptoms at the onset of interferon β- 1b therapy in multiple sclerosis by low-dose oral steroids is related to a decrease in interleukin-6 induction

1998 ◽  
Vol 44 (4) ◽  
pp. 682-685 ◽  
Author(s):  
E. M. MartíNez-CáCeres ◽  
J. Río ◽  
M. Barrau ◽  
I. Durán ◽  
C. Borrás ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Interleukin 6 ◽  
Low Dose ◽  
Interferon Β ◽  
Oral Steroids ◽  
Dose Oral

Long-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal women

2006 ◽  
Vol 22 (11) ◽  
pp. 627-635 ◽  
Author(s):  
Andrea R. Genazzani ◽  
Nicola Pluchino ◽  
Silvia Begliuomini ◽  
Massimo Stomati ◽  
Francesca Bernardi ◽  
...  
Keyword(s):  
Oral Administration ◽  
Postmenopausal Women ◽  
Adrenocorticotropic Hormone ◽  
Low Dose ◽  
Dose Oral ◽  
Adrenal Response

Long-term follow-up of fixed low-dose oral immunotherapy for children with wheat-induced anaphylaxis

2021 ◽  
Author(s):  
Ken-ichi Nagakura ◽  
Yoko Miura ◽  
Takaaki Itonaga ◽  
Makoto Nishino ◽  
Kyohei Takahashi ◽  
...  
Keyword(s):  
Low Dose ◽  
Oral Immunotherapy ◽  
Long Term Follow Up ◽  
Dose Oral

Inflammatory myofibroblastic tumour of the conjunctiva masquerading as ocular surface squamous neoplasia

2020 ◽  
pp. 112067212097361
Author(s):  
Manpreet Singh ◽  
Manu Saini ◽  
Debajyoti Chatterjee ◽  
Aditi Mehta ◽  
Manpreet Kaur ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Ocular Surface ◽  
Surgical Excision ◽  
Excision Biopsy ◽  
Inflammatory Myofibroblastic Tumour ◽  
Complete Surgical Excision ◽  
Oral Steroids ◽  
Rare Site ◽  
The Right

A 63-year-male had painless, progressive, yellowish-pink, immobile conjunctival mass with prominent feeder vessels in the right eye of 1-year duration. The rest of the ophthalmic examination was unremarkable. MRI showed no extension into orbit or extraocular muscles. An excision biopsy with the amniotic membrane patch was performed. Histopathology confirmed inflammatory myofibroblastic tumour (IMT) with SMA and calponin positivity on immunohistochemistry. Complete surgical excision, amniotic membrane, and oral steroids provided long-term relief from recurrence. The conjunctiva is a rare site for IMT, and IMT should be kept in the differentials for atypical cases of ocular surface neoplasia.

Author response for "Long‐term follow‐up of fixed low‐dose oral immunotherapy for children with severe cow’s milk allergy"

2020 ◽  
Author(s):  
Yoko Miura ◽  
Ken‐ichi Nagakura ◽  
Makoto Nishino ◽  
Mari Takei ◽  
Kyohei Takahashi ◽  
...  
Keyword(s):  
Low Dose ◽  
Oral Immunotherapy ◽  
Author Response ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Long Term Follow Up ◽  
Dose Oral

scholarly journals Effects of Cranberry Juice on Pharmacokinetics of β-Lactam Antibiotics following Oral Administration

2009 ◽  
Vol 53 (7) ◽  
pp. 2725-2732 ◽  
Author(s):  
Meng Li ◽  
Marilee A. Andrew ◽  
Joanne Wang ◽  
David H. Salinger ◽  
Paolo Vicini ◽  
...  
Keyword(s):  
Low Dose ◽  
Recurrent Urinary Tract Infection ◽  
Oral Absorption ◽  
Test Dose ◽  
Membrane Transporters ◽  
Oral Antibiotics ◽  
Cranberry Juice ◽  
Oral Test ◽  
Concurrent Use ◽  
Dose Oral

ABSTRACT Cranberry juice consumption is often recommended along with low-dose oral antibiotics for prophylaxis for recurrent urinary tract infection (UTI). Because multiple membrane transporters are involved in the intestinal absorption and renal excretion of β-lactam antibiotics, we evaluated the potential risk of pharmacokinetic interactions between cranberry juice and the β-lactams amoxicillin (amoxicilline) and cefaclor. The amoxicillin-cranberry juice interaction was investigated in 18 healthy women who received on four separate occasions a single oral test dose of amoxicillin at 500 mg and 2 g with or without cranberry juice cocktail (8 oz) according to a crossover design. A parallel cefaclor-cranberry juice interaction study was also conducted in which 500 mg cefaclor was administered with or without cranberry juice cocktail (12 oz). Data were analyzed by noncompartmental methods and nonlinear mixed-effects compartmental modeling. We conclude that the concurrent use of cranberry juice has no significant effect on the extent of oral absorption or the renal clearance of amoxicillin and cefaclor. However, delays in the absorption of amoxicillin and cefaclor were observed. These results suggest that the use of cranberry juice at usual quantities as prophylaxis for UTI is not likely to alter the pharmacokinetics of these two oral antibiotics.

scholarly journals An Unusual Transorbital Penetrating Injury and Principles of Management

2014 ◽  
Vol 7 (4) ◽  
pp. 310-312 ◽  
Author(s):  
AndrewPeter Dekker ◽  
AbdelHamid El-Sawy ◽  
DariusStephen Rejali
Keyword(s):  
Visual Acuity ◽  
Case Report ◽  
Multidisciplinary Approach ◽  
Penetrating Injury ◽  
Significant Morbidity ◽  
Low Velocity ◽  
Cranial Fossa ◽  
The Right ◽  
Ethmoid Sinuses

The objective of this study was to present an unusual low velocity transorbital penetrating injury. The study design was a clinical record (case report). A 38-year-old gentleman tripped and fell face first onto the wing of an ornamental brass eagle. This penetrated the inferomedial aspect of the right orbit, breaching the lamina papyracea to extend into the ethmoid sinuses and reaching the dura of the anterior cranial fossa. The foreign body was removed in theater under a joint ophthalmology and ENT procedure. The patient was left with reduced visual acuity in the right eye but no other long-term sequelae. Transorbital penetrating injury presents unusual challenges to investigation and management requiring a multidisciplinary approach to prevent significant morbidity and mortality. If managed well the prognosis is good.

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