scholarly journals Association of Vitamin D with Inflammatory Bowel Disease Activity in Pediatric Patients

2019 ◽  
Vol 34 (32) ◽  
Author(s):  
Seoyoung Kim ◽  
Yunkoo Kang ◽  
Sowon Park ◽  
Hong Koh ◽  
Seung Kim
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Disease Activity ◽  
Bowel Disease ◽  
Pediatric Patients ◽  
Inflammatory Bowel

P-052 YI Vitamin D Status and Inflammatory Bowel Disease—The Role in Disease Activity and Quality of Life

2013 ◽  
Vol 19 ◽  
pp. S48
Author(s):  
Francisca Dias de Castro ◽  
Joana Magalhães ◽  
Pedro Carvalho ◽  
Maria João Moreira ◽  
Paula Mota ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Disease Activity ◽  
Bowel Disease ◽  
Vitamin D Status ◽  
Inflammatory Bowel

S2003 Serum Vitamin D Level and Disease Activity in Pediatric Inflammatory Bowel Disease

2010 ◽  
Vol 138 (5) ◽  
pp. S-299
Author(s):  
Adam Safdi ◽  
Sharon D'Mello ◽  
Thomas D. Walters ◽  
Anne M. Griffiths ◽  
Lee Denson
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Disease Activity ◽  
Bowel Disease ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Pediatric Inflammatory Bowel Disease ◽  
Inflammatory Bowel

scholarly journals P298 Vitamin D status and inflammatory bowel disease – the role in disease activity and quality of life

2014 ◽  
Vol 8 ◽  
pp. S188
Author(s):  
F. Dias de Castro ◽  
J. Magalhães ◽  
P. Boal Carvalho ◽  
M.J. Moreira ◽  
P. Mota ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Disease Activity ◽  
Bowel Disease ◽  
Vitamin D Status ◽  
Inflammatory Bowel

scholarly journals AB1281-HPR THE LEVELS OF VITAMIN D IN THE SPONDYLOARTHRITIS. DOES THE DEFICIT CORRESPOND TO THE INFLAMMATORY ACTIVITY?

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1931.1-1931
Author(s):  
D. Castro-Corredor ◽  
M. A. Ramírez Huaranga ◽  
A. I. Rebollo Giménez ◽  
M. D. Mínguez Sánchez ◽  
J. Anino-Fernández ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Vitamin D Deficiency ◽  
Bowel Disease ◽  
Inflammatory Activity ◽  
Mineral Density ◽  
Vitamin D Levels ◽  
Inflammatory Bowel

Background:Spondyloarthritis is a group of chronic inflammatory diseases with involvement of the axial skeleton (mainly), and also of peripheral joints. Patients with spondyloarthritis have a significant prevalence of vitamin D levels below normal and that would correlate with the degree of activity of the disease.Objectives:To determine the association between vitamin D deficiency and the degree of activity of the disease (inflammatory activity) in a cohort of patients with spondyloarthritis.Methods:Case-control type analytical observational study. We propose a retrospective review of the database of patients with spondyloarthritis (according ASAS2010 criteria) who were treated in the outpatient clinics of the Rheumatology Service of the General University Hospital of Ciudad Real during June 2018 to June 2019. Patients with the data will be selected. necessary for the analysis of the variables under study. The numerical variables of normal distribution evaluated will be described using measures of frequency and measures of central tendency / dispersion as appropriate. To assess the association between vitamin D levels and activity index, the odds ratio (OR) is calculated, with a 95% confidence level and the T-student for related samples.Results:The final results of the study are presented. 115 patients were analyzed, of which 64 were men and 51 women, with an average age of 45.97 years (+/- 13.41 DE). 47% were ankylosing spondylitis, 21% psoriatic arthropathy, 16% undifferentiated spondyloarthritis, 7% spondyloarthropathy associated with inflammatory bowel disease and 9% were spondyloarthropathy associated with inflammatory bowel disease. The average of the activity was a BASDAI of 4.57 (+/- 2.35 SD) and measured by DAPSA was 12.61 (+/- 6.76 SD). 63 and 14 patients had activity measured by BASDAI and DAPSA, respectively. 49.56% patients presented an elevation of acute phase reactants. Vitamin D levels were 23.81 (+/- 10.5 SD). 77.4% presented figures of vitamin D deficiency or insufficiency. When performing the association analysis, the vitamin D deficit / insufficiency presented an OR 10 (95% CI: 3.66-27.29, p=<0.0001) with the degree of activity measured with BASDAI and DAPSA and against the elevation of RCP it was 3.63 (95% CI 1.43-9.25, p = 0.0092) and against the elevation of ESR it was 2.76 (95% CI 1.09-7, 0, p = 0.0438). Regarding the comparative analysis of means between vitamin D deficiency/insufficiency and BASDAI/DAPSA it was +3.29 (95% CI: 1.34-8.09, p=0.0084).Conclusion:Patients with spondyloarthritis, as in other autoimmune diseases, vitamin D deficiency is associated with increased inflammatory activity (BASDAI, DAPSA, RCP and ESR), measured in different time periods. Therefore, an optimization of vitamin D levels can imply an improvement in the patient’s clinical situation, measured by both BASDAI and DAPSA, as well as by RCP and ESR.In addition, it is necessary to monitor bone mineral density due to the risk of fracture in these patients for their multietiology (corticosteroid treatments, biological FAMEs, inflammatory activity).References:[1]Lange U, Teichmann J, Strunk J, Müller-Ladner U, Schmidt KL. Association of 1.25 vitamin D3 deficiency, disease activity and low bone mass in ankylosing spondylitis. Osteoporos Int. 2005;16:1999-2004.[2]Durmus B, Altay Z, Baysal O, Ersoy Y. Does vitamin D affect disease severity in patients with ankylosing spondylitis? Chin Med J. 2012;125:2511-2515.[3]Mermerci Baskan B, Pekin Dogan y, Sivas F, Bodur H, Ozoran K. The relation between osteoporosis and vitamin D levels and disease activity in ankylosing spondylitis. Rheumatol Int. 2010;30:375-381.Disclosure of Interests:None declared

scholarly journals Laboratory Assessment of Disease Activity in Pediatric Patients with Inflammatory Bowel Disease: What’s New?

2020 ◽  
Vol 11 (2) ◽  
pp. 58-71
Author(s):  
Rayna Shentova-Eneva ◽  
Tsvetelina Velikova
Keyword(s):  
Inflammatory Bowel Disease ◽  
Disease Activity ◽  
Bowel Disease ◽  
Laboratory Tests ◽  
Pediatric Patients ◽  
Clinical Activity ◽  
Full Potential ◽  
Inflammatory Bowel ◽  
Pediatric Ibd

Laboratory tests are an integral part of both the diagnostic and follow-up algorithm of patients with inflammatory bowel disease (IBD). Their advantages over other non-invasive methods for assessing disease activity are greater objectivity than clinical activity indices and imaging studies. This review aims to analyze shortly the most common laboratory tests used to assess disease activity in pediatric patients with IBD. In addition to the conventional blood and serum markers that are not specific for gut inflammation, although routinely used, we also reviewed the established fecal markers such as calprotectin, lactoferrin, M2-pyruvate kinase, osteoprotegerin, HMGB1, chitinase 3-like 1, and the promising non-coding microRNA. In conclusion, neither marker is unique to the pediatric IBD. More clinical data are required to assess biomarkers’ full potential for diagnosis, management, and follow-up of pediatric IBD patients.

scholarly journals Relationship Between Vitamin D Deficiency and Disease Activity in Patients with Inflammatory Bowel Disease in Ahvaz, Iran

2020 ◽  
Vol Volume 13 ◽  
pp. 419-425
Author(s):  
Esmat Rasouli ◽  
Narges Sadeghi ◽  
Abazar Parsi ◽  
Seyed Jalal Hashemi ◽  
Morteza Nayebi ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Disease Activity ◽  
Vitamin D Deficiency ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Serum vitamin D but not zinc levels are associated with different disease activity status in patients with inflammatory bowel disease

Medicine ◽  
2019 ◽  
Vol 98 (15) ◽  
pp. e15172 ◽  
Author(s):  
Nicolae-Catalin Mechie ◽  
Eirini Mavropoulou ◽  
Volker Ellenrieder ◽  
Golo Petzold ◽  
Steffen Kunsch ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Disease Activity ◽  
Bowel Disease ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Inflammatory Bowel ◽  
Zinc Levels
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