Adverse Reactions of the Second Dose of the BNT162b2 mRNA COVID-19 Vaccine in Healthcare Workers in South Korea

BACKGROUND In April 2020, two independent clinical trials (CT) to assess SARS-Cov-2 prophylaxis in healthcare workers were started in our Hospital: MeCOVID (melatonin vs placebo) and EPICOS (tenofovir disoproxil/emtricitabine vs hydroxychloroquine vs the combination of both vs placebo). OBJECTIVE We aim to evaluate the motivations to participate and the reasons to choose one or another. METHODS Both CTs were offered to personnel through the internal news bulletin. After the screening visit, all subjects were asked to answer a web-based survey. RESULTS In the first month, 206 healthcare workers were screened and 160 randomized. Survey participation was quite high, 73.3%. The main motivation to participate was “to contribute to scientific knowledge” 53.0%, followed by “to avoid SARS-Cov-2 infection” and “the interest to be tested for SARS-CoV-2”. We found differences between physicians and nurses in the expected personal benefits (P<0.05). The vast majority of the volunteers selected the MeCOVID study, the main reason was the fear of adverse reactions associated with treatments in EPICOS, 69.4%. CONCLUSIONS Healthcare workers´ motivations to participate in prophylaxis trials in a pandemic context appear to be driven mostly by their desire to contribute to science and getting some health benefits. Safety seems to weight way more than efficacy to choose between CTs.

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Healthcare Workers Infection in South Korea and Italy During the Pandemic of COVID-19: A Retrospective Study Based on Open Data

SSRN Electronic Journal ◽

10.2139/ssrn.3696803 ◽

2020 ◽

Author(s):

Kexin Zhang ◽

Jiarui Yang ◽

Ziyuan Liu ◽

Xiaodan Jiang ◽

Ruilan Dong ◽

...

Keyword(s):

Retrospective Study ◽

South Korea ◽

Healthcare Workers ◽

Open Data

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Antibody Response to Live Attenuated Vaccines in Adults in Japan

Open Medicine ◽

10.1515/med-2016-0085 ◽

2016 ◽

Vol 11 (1) ◽

pp. 482-488 ◽

Cited By ~ 2

Author(s):

Taku Ogawa ◽

Fukumi Uchiyama-Nakamura ◽

Aiko Sugata-Tsubaki ◽

Yutaka Yamada ◽

Kenji Uno ◽

...

Keyword(s):

Single Dose ◽

Antibody Titer ◽

Healthcare Workers ◽

Adverse Reactions ◽

Varicella Vaccine ◽

Limited Sample ◽

Live Attenuated Vaccine ◽

Post Vaccination ◽

Vaccination Response ◽

Severe Adverse Reactions

AbstractThe purpose of this study was to examine the efficacy rendered with a single dose of live attenuated measles, rubella, mumps, and varicella containing vaccine.We inoculated healthcare workers (HCWs) with a single dose of vaccine to a disease lacking in antibody titer for those not meeting the criteria of our hospital (measles: <16.0 (IgG enzyme immunoassay (EIA)), rubella: ≤1:32 (hemagglutination-inhibition), mumps: <4.0 (IgG EIA), and varicella: <4.0 (IgG EIA)). At 28–60 days after vaccination, the antibody titer was tested again.We included 48 HCWs. A total of 32, 15, 31, and 10 individuals were inoculated with a single dose of measles-containing, rubella-containing, mumps, or varicella vaccine, respectively, and showed significant antibody elevation (9.2 ± 12.3 to 27.6 ± 215.6, p<0.001; 8 ± 1.2 to 32 ± 65.5, p<0.001; 3.0 ± 1.0 to 13.1 ± 8.6, p<0.05; and 2.6 ± 1.3 to 11.8 ± 8.1, p<0.001, respectively). Major side effects were not observed.In a limited population, a single dose of live attenuated vaccine showed elevation of antibody titer without any severe adverse reactions. However, whether the post-vaccination response rate criteria of our university was fulfilled could not be determined owing to limited sample size.

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Seroprevalence of Measles in Healthcare Workers in South Korea

Infection and Chemotherapy ◽

10.3947/ic.2019.51.1.58 ◽

2019 ◽

Vol 51 (1) ◽

pp. 58 ◽

Cited By ~ 4

Author(s):

Jiwon Jung ◽

Sun-Kyung Kim ◽

Sun Hee Kwak ◽

Min Jee Hong ◽

Sung-Han Kim

Keyword(s):

South Korea ◽

Healthcare Workers

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Adverse Reactions Associated With Respirator Fit Testing of Healthcare Workers in British Columbia, Canada: A Review of Compensation Claim Cases

Archives of Environmental & Occupational Health ◽

10.3200/aeoh.62.4.197-200 ◽

2007 ◽

Vol 62 (4) ◽

pp. 197-200 ◽

Cited By ~ 3

Author(s):

Sami Youakim

Keyword(s):

British Columbia ◽

Healthcare Workers ◽

Adverse Reactions ◽

Compensation Claim ◽

Fit Testing

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Seroprevalence of Measles in Healthcare Workers in South Korea

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2020.1022 ◽

2020 ◽

Vol 41 (S1) ◽

pp. s386-s387

Author(s):

Sun Kyung Kim ◽

Jiwon Jung ◽

Sun Hee Kwak ◽

Min Jee Hong ◽

Eun Ok Kim ◽

...

Keyword(s):

South Korea ◽

Birth Cohort ◽

Healthcare Workers ◽

Medical Center ◽

Adult Population ◽

Care Hospital ◽

Healthcare Facilities ◽

Asan Medical ◽

Measles Vaccination ◽

Antibody Tests

Background: Measles is a highly contagious disease that is transmissible by airborne particles but is preventable by vaccination. South Korea has maintained a highly immunized adult population; however, small local outbreaks of measles continued to occur, and there have been some reports of pockets of underimmunity among the young adult population. It is important to know the seroepidemiology of healthcare workers (HCWs) for policy-making process, but data on the seroprevalence of measles in HCWs in South Korea are limited. Methods: We investigated the seroprevalence of HCWs at Asan Medical Center, a 2,705-bed tertiary-care hospital in Seoul, South Korea, with 8,329 HCWs. In 2014, after an outbreak of measles occurred in a university in Seoul, Asan Medical Center required measles IgG tests for all HCWs born in and after 1967 for point-prevalence surveillance. In addition, we have routinely performed measles antibody test for new HCWs since 2014. In 2018, antibody tests were administered to HCWs who were born before 1967 or who had taken a leave of absence in 2014. We provided MMR vaccination to all HCWs whose antibody tests yielded negative results. Results: In total, 7,411 HCWs (89%) underwent measles antibody tests from 2014 to 2018. The overall seropositivity was 73% (95% CI, 72%–74%); seroprevalence was 73% in HCWs born in of after 1967, whereas the seroprevalence in HCWs born before 1967 was 98%. The seroprevalence sharply decreased from 85% in the 1986 birth cohort to 42% in the 1995 birth cohort. Conclusions: In conclusion, the proportion of measles-susceptible individuals was substantially high in HCWs, especially in young adults. Because the impact of measles outbreak in healthcare facilities would be critical, a policy regarding routine serologic screening followed by measles vaccination or routine measles vaccination in healthcare facilities should be considered, especially for young Korean HCWs.Funding: NoneDisclosures: None

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