Clinicopathological distinction of two categories of oral squamous cell carcinoma of the tongue: de novo vs. sequential types

2012 ◽  
Vol 16 (3+4) ◽  
pp. 81-88 ◽  
Author(s):  
Masanao Saito ◽  
Takanori Kobyashi ◽  
Ritsuo Takagi ◽  
Takashi Saku
Head & Neck ◽  
2016 ◽  
Vol 39 (2) ◽  
pp. 297-304 ◽  
Author(s):  
Jia Hui Ng ◽  
N. Gopalakrishna Iyer ◽  
Min-Han Tan ◽  
Gustaf Edgren

Cancers ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1166 ◽  
Author(s):  
Xin-Hui Khoo ◽  
Ian C. Paterson ◽  
Bey-Hing Goh ◽  
Wai-Leng Lee

Drug resistance remains a severe problem in most chemotherapy regimes. Recently, it has been suggested that cancer cell-derived extracellular vesicles (EVs) could mediate drug resistance. In this study, the role of EVs in mediating the response of oral squamous cell carcinoma (OSCC) cells to cisplatin was investigated. We isolated and characterized EVs from OSCC cell lines showing differential sensitivities to cisplatin. Increased EV production was observed in both de novo (H314) and adaptive (H103/cisD2) resistant lines compared to sensitive H103 cells. The protein profiles of these EVs were then analyzed. Differences in the proteome of EVs secreted by H103 and H103/cisD2 indicated that adaptation to cisplatin treatment caused significant changes in the secreted nanovesicles. Intriguingly, both resistant H103/cisD2 and H314 cells shared a highly similar EV protein profile including downregulation of the metal ion transporter, ATP1B3, in the EVs implicating altered drug delivery. ICP-MS analysis revealed that less cisplatin accumulated in the resistant cells, but higher levels were detected in their EVs. Therefore, we inhibited EV secretion from the cells using a proton pump inhibitor and observed an increased drug sensitivity in cisplatin-resistant H314 cells. This finding suggests that control of EV secretion could be a potential strategy to enhance the efficacy of cancer treatment.


Head & Neck ◽  
2015 ◽  
Vol 38 (7) ◽  
pp. 993-1001 ◽  
Author(s):  
Max Riemann ◽  
Christian Knipfer ◽  
Maximilian Rohde ◽  
Werner Adler ◽  
Maria Schuster ◽  
...  

Author(s):  
Patrícia Colombo Corrêa ◽  
Íris Mattos Santos-Pirath ◽  
Chandra Chiappin Cardoso ◽  
Camila Mattiolo ◽  
Bruno Vieira Dias ◽  
...  

Aims: We report a rare case of therapy-related AML with t(8;21)(q22;q22.1) that occurred after treatment for mantle cell lymphoma (MCL) and oral squamous cell carcinoma (OSCC). Presentation of Case: A 52 years-old male patient was diagnosed with MCL in leukemic phase. The treatment consisted in R-CHOP rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone, then patient experienced remission. Three months later, he presented a lump that was diagnosed as OSCC, which was surgically removed and treated with cisplatin and radiotherapy. Then, the patient’s hemogram presented 35.0% of blasts and, after morphologic, phenotypic and molecular analysis, it was classified as AML with t(8;21)(q22;q22.1). However, due to the previous historic of chemotherapy and radiotherapy, the final diagnosis was t-AML. Discussion: The correct diagnosis of therapy related malignancies is important due to its severity as they are very aggressive and, usually, considered incurable. t-AMLs with t(8;21)(q22;q22.1) is considered as favorable karyotype, still, it has a poorer outcome compared with its de novo counterpart. Conclusion: t-AML with t(8;21)(q22;q22.1) is rare and few cases are described in the literature. More reports are necessary to better elucidate the mechanisms involved in this disease to define better treatment strategies to prevent these events and to improve the poor outcomes.


2020 ◽  
Vol 8 (11) ◽  
Author(s):  
Dannilo Wiklymber Roldao Mendonça ◽  
Helinaldo Corrêa da Conceicao ◽  
Gleicy Gomes de Lima ◽  
Maria de Fátima Araújo ◽  
Lioney Nobre Cabral ◽  
...  

O câncer de boca representa um problema de saúde pública em todo o mundo, das neoplasias malignas que podem afetar a cavidade oral, o carcinoma espinocelular (CEC), destaca-se por cerca de 90% de todas as lesões malignas diagnosticadas na boca. Descrever o diagnóstico de um caso de (CEC) em região de assoalho bucal em um paciente tabagista. Paciente com 43 anos de idade, sexo masculino, melanoderma, garimpeiro, cor parda, compareceu ao atendimento na Policlínica Odontológica da Universidade do Estado do Amazonas (UEA) para exame estomatológico de rotina. Durante a anamnese o paciente relatou ser tabagista e etilista há mais de 30 anos e fazia uso de cigarros de maconha frequentemente. Ainda através da anamnese, soube-se que o paciente foi exposto por muito tempo à luz solar quando o mesmo trabalhava como garimpeiro. Mencionou também sentir bastante dor e ardência na região da lesão. Diante das informações clínicas colhidas, chegou-se à hipótese diagnóstica de (CEC). O diagnóstico foi confirmado por meio de biopsia incisional e exame histopatológico, com posterior encaminhamento para tratamento médico junto ao centro de controle de oncologia de Manaus (AM). Compete ao cirurgião-dentista diagnosticar e tratar em conjunto com outras especialidades, já que o diagnóstico precoce desta neoplasia torna-se essencial.Descritores: Neoplasias Bucais; Carcinoma de Células Escamosas; Soalho Bucal.ReferênciasFerlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M et al. Cancer incidence and mortality wordwide: sources, methods and major patterns in Globocan 2012. Int J Cancer. 2015;136(5):E359-386.Instituto Nacional de Câncer Jose Alencar Gomes da Silva. Estimativa 2018: incidência de câncer no Brasil / Coordenação de Prevenção e Vigilância. – Rio de Janeiro: INCA, 2017.Dib LL, Sabba LMB, Marques LA, Araújo NS. Fatores prognósticos em carcinoma de bordas de língua: análise clínica e histopatológica. Acta Oncol Bras. 1994;14(2):88-93.Regezi JA, Sciubba JJ, Jordan RCK. Patologia oral: correlações clinicopatológicas. 5. Ed. Rio de Janeiro: Elsevier; 2008.Neville BW, Damm DD, Alen CM, Bouquot JE.  Patologia oral e maxilofacial. Rio de Janeiro: Elsevier; 2009.Abreu MAMM, Pimentel DRN, Silva OMP, Blachman IT, Michalany NS, Hirata CH et al. Squamous cell carcinoma of the lip: assessment of prognostic factors. Rev Bras Otorrinolaringol. 2004;70(6):765-70.Oliveira LR, Ribeiro Silva A, Zucoloto S. Perfil da incidência e da sobrevida de pacientes com carcinoma epidermóide oral em uma população brasileira. J Bras Patol Med Lab. 2006;42(5):385-92.Figuero Ruiz E, Carretero Peláez MA, Cerero Lapiedra R, Esparza Gómez G, Moreno López LA. Effects of the consumption of alcohol in the oral cavity: relationship with oral cancer. Med Oral. 2004;9(1):14-23.Fardin M, Freitas SM, Dedivitis RA, Rapoport A, Denardin OVP, A-Sobrinho J. Fatores de risco no prognóstico do câncer da boca: estudo de 1440 casos. Rev Bras Cirurgia Cabeça Pescoço. 2004;33(1):27-33.Silva PSL, Leão VML, Scarpel RD. Caracterização da população portadora de câncer de boca e orofaringe atendida no setor de cabeça e pescoço em hospital de referência na cidade de Salvador – BA. Rev CEFAC. 2009;11(3):441-47.Souza LRB, Ferraz KD, Pereira NS, Martins MV. Conhecimento acerca do câncer bucal e atitudes frente à sua etiologia e prevenção em um grupo de horticultores de Teresina (PI). Rev Bras Cancerol. 2012;58(1):31-9.Syrjänen S, Lodi G, von Bultzingslowen I, Aliko A, Arduino P, Campisi G et al. Human papilloma viruses in oral carcinoma and oral potentially malignant disorders: a systematic review. Oral Dis. 2011;17(Suppl 1):58-72.Vidal AKL, Caldas Júnior AF, Mello RJV, Brandão VRA, Rocha GI, Taromaru E. J Bras Patol Med Lab. 2004;40(1):21-6.Sina M, Pedram M, Ghojazadeh M, Kochaki A, Aghbali A. P53 gene codon 72 polymorphism in patients with oral squamous cell carcinoma in the population of northern Iran. Med Oral Patol Oral Cir Bucal. 2014;19(6):e550-55.Marchioni DML, Fisberg RM, Gois Filho JF, Kowalski LP, Carvalho MB, Abrahão M et al. Fatores dietéticos e câncer oral: estudo caso-controle na região metropolitana de São Paulo, Brasil. Cad Saúde Pública. 2007;23(3):553-64.Paiva M, Pileggi C, Nobile CGA, Angelillo IF. Association between fruit and vegetable consumption and oral cancer: a meta-analysis of observational studies. Am J Clin Nutr. 2006;83(5):1126-34.Brown LM, Moradi T, Gridley G, Plato N, Dosemeci M, Fraumeni Jr JF. Exposures in the paiting trades and paint manufacturing industry and risck among men and women in Sweden. J Occup Environ Med. 2002;44(3):258-64.Silva MFA. Avaliação da condição de saúde bucal e da qualidade de vida em pacientes com câncer de cabeça e pescoço após radioterapia [monografia]. Campina Grande: UEPB; 2012.Coaracy AEV, Lopes FF, Cruz MCFN, Bastos EG. Correlação entre os dados clínicos e histopatológicos dos casos de carcinoma espinocelular oral do Instituto Maranhense de Oncologia Aldenora Bello, em São Luís, MA. J Bras Patol Med Lab. 2008;44(1): 31-5.Iamarron A, Pattanaporn K, Pongsiriwet S, Wanachantararak S, Prapayasatok S,Jittidecharaks S et al. Analysis of 587 cases of oral squamous cell carcinoma in northern Thailand with a focus on young people. Int J Oral Maxillofac Surg. 2004;33(1):84-8.Sassi LM, Oliveira BV, Pedruzzi PAG, Ramo GHA, Stramandinoli RT, Gugelmin G et al. Carcinoma espinocelular de boca em paciente jovem: relato de caso e avaliação dos fatores de risco. RSBO. 2010;7(1):105-9.Friedlander PL, Schantz SP, Shaha AR, Yu G, Shah JP. Squamous cell carcinoma of the tongue in young patients: a matched-pair analysis. Head Neck. 1998;20(5):363-68.Gomes LC, Macena FCS, Ferreira VS, Barreto VR. Revisão de Literatura: câncer de boca - diagnóstico e fatores de riscos associados. Rev Interdisciplinar em saúde. 2018;5(4):655-70.Myers JN, Elkins T, Roberts D, Byers RM. Squamous cell carcinoma of the tongue in young adults: increasing incidence and factors that predict treatment outcomes. Otolaryngol Head Neck Surg. 2000;122(1):44-51.Souza DP. Carcinoma espinocelular relacionado ao hábito de mascar tabaco: relato de caso clínico [monografia]. Manaus: Universidade do Estado do Amazonas – UEA; 2017.


2011 ◽  
Vol 15 (4) ◽  
pp. 107-112 ◽  
Author(s):  
Shoko Tsuruoka ◽  
Kou Matsuo ◽  
Ayataka Ishikawa ◽  
Noriaki Yamamoto ◽  
Yoshihiro Yamashita ◽  
...  

Author(s):  
RENEE OLIVEIRA DO NASCIMENTO ◽  
CAMILA MARIA BEDER RIBEIRO G. PANJWANI ◽  
VERA LUCIA TENóRIO CORREIA DA SILVA ◽  
CATARINA RODRIGUES ROSA DE OLIVEIRA ◽  
CLAYTON CLENISSON DE CARVALHO SILVA ◽  
...  

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