scholarly journals A comparative study between topical insulin versus normal saline dressings in wound healing in diabetic foot ulcers

2019 ◽  
Vol 3 (1) ◽  
pp. 26-32
Author(s):  
Dr. Vijay V Kamat ◽  
Dr. CG Sunil
Keyword(s):  
Wound Healing ◽  
Comparative Study ◽  
Normal Saline ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

scholarly journals A COMPARATIVE STUDY OF IONIC SILVER BASED DRESSINGS VERSUS CONVENTIONAL DRESSINGS IN MANAGEMENT OF DIABETIC FOOT ULCERS.

2020 ◽  
pp. 77-79
Author(s):  
Ravishankar. N ◽  
Shivakumar. S ◽  
Abirami. K
Keyword(s):  
Wound Healing ◽  
Comparative Study ◽  
Diabetic Foot ◽  
T Test ◽  
Foot Ulcers ◽  
Colloidal Silver ◽  
Diabetic Foot Ulcers ◽  
Ulcer Area ◽  
Ionic Silver ◽  
End Point

AIMS: To compare the efficacy of ionic silver-based dressings with conventional saline dressings in the management of diabetic foot ulcers. OBJECTIVES: To study the efficacy of ionic silver based amorphous hydrogel dressing containing colloidal silver in management of diabetic foot ulcer healing and to compare the time taken for wound healing, number of days taken to reach the end point and cost-effectiveness, with that of conventional saline dressings. METHODS: This was a case control, prospective, comparative study conducted in Department of Surgery, JSS Hospital, Mysuru. Totally 100 patients with diabetic foot ulcers were included, equally divided into -cases (received colloidal silver dressings) and controls (received saline dressings), Simple randomization was done. Study Duration- 18 Months. Data collected regarding changes in wound size, presence of granulation tissue, slough, presence or absence of discharge, was analysed - by Chi square test, Independent T test and Paired T test. RESULTS: There was significant percentage reduction in ulcer area, 66.76±16.8 % in colloidal silver group, compared to only 2.71±4.53% in conventional saline group. The number of days to end point was significantly lesser in colloidal silver group, compared to conventional group (23.16±8.16 days vs 48.34±18.06 days), reduction of ulcer area (from 100%) was more at day 14 (48% in silver group, 89.69% in conventional group). CONCLUSION: The faster rate of wound healing in lesser number of days with significantly more reduction in ulcer area over a period of time, shows that ionic silver based amorphous hydrogel wound dressings with colloidal silver is more efficient than conventional saline dressings in diabetic foot ulcers management. As the number of dressings and number of days to end point is significantly lesser, ionic silver-based dressings are a comparatively more cost-effective treatment option as per our study.

Punch Grafting for the Management of Hard-to-Heal Diabetic Foot Ulcers: A Prospective Case Series

2021 ◽  
pp. 153473462110310
Author(s):  
Marta García-Madrid ◽  
Irene Sanz-Corbalán ◽  
Aroa Tardáguila-García ◽  
Raúl J. Molines-Barroso ◽  
Mateo López-Moral ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Outcomes ◽  
Diabetic Foot ◽  
Donor Site ◽  
Case Series ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Wound Debridement ◽  
Prospective Case Series

Punch grafting is an alternative treatment to enhance wound healing which has been associated with promising clinical outcomes in various leg and foot wound types. We aimed to evaluate the clinical outcomes of punch grafting as a treatment for hard-to-heal diabetic foot ulcers (DFUs). Six patients with chronic neuropathic or neuroischemic DFUs with more than 6 months of evolution not responding to conventional treatment were included in a prospective case series between May 2017 and December 2020. All patients were previously debrided using an ultrasound-assisted wound debridement and then, grafted with 4 to 6 mm punch from the donor site that was in all cases the anterolateral aspect of the thigh. All patients were followed up weekly until wound healing. Four (66.7%) DFUs were located in the heel, 1 (16.7%) in the dorsal aspect of the foot and 1 (16.7%) in the Achilles tendon. The median evolution time was 172 (interquartile range [IQR], 25th-75th; 44-276) weeks with a median area of 5.9 (IQR; 1.87-37.12) cm2 before grafting. Complete epithelization was achieved in 3 (50%) patients at 12 weeks follow-up period with a mean time of 5.67 ± 2.88 weeks. Two of the remaining patients achieved wound healing at 32 and 24 weeks, respectively, and 1 patient showed punch graft unsuccessful in adhering. The median time of wound healing of all patients included in the study was 9.00 (IQR; 4.00-28.00) weeks. The wound area reduction (WAR) at 4 weeks was 38.66% and WAR at 12 weeks was 88.56%. No adverse effects related to the ulcer were registered through the follow-up period. Autologous punch graft is an easy procedure that promotes healing, achieving wound closure in chronic DFUs representing an alternative of treatment for hard-to-heal DFUs in which conservative treatment has been unsuccessful.

Therapeutic Properties of Honey for the Management of Wounds; Is There a Role in the Armamentarium of Diabetic Foot Ulcer Treatment? Results From In vitro and In vivo Studies

2021 ◽  
pp. 153473462110268
Author(s):  
Ioanna A. Anastasiou ◽  
Ioanna Eleftheriadou ◽  
Anastasios Tentolouris ◽  
Georgia Samakidou ◽  
Nikolaos Papanas ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Diabetic Animal ◽  
Cochrane Library ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Therapeutic Properties

Diabetic foot ulcers are one of the most dreadful complications of diabetes mellitus and efforts to accelerate diabetic wound healing are of paramount importance to prevent ulcer infections and subsequent lower-limb amputations. There are several treatment approaches for the management of diabetic foot ulcers and honey seems to be a safe and cost-effective therapeutic approach on top of standard of care. The aim of this review was to summarize the therapeutic properties of honey and the data regarding its possible favorable effects on diabetic wound healing. A literature search of articles from 1986 until April 2021 was performed using MEDLINE, EMBASE, and the Cochrane Library to assess for studies examining the therapeutic wound healing properties of honey, it's in vitro effect, and the efficacy and/or mechanism of action of several types of honey used for the treatment of diabetic animal wounds. Honey has antioxidant, anti-inflammatory, and antibacterial properties and in vitro studies of keratinocytes and fibroblasts, as well as studies in diabetic animal models show that treatment with honey is associated with increased re-epithelialization and collagen production, higher wound contraction, and faster wound healing. The use of honey could be a promising approach for the management of diabetic foot ulcers.

scholarly journals Surgical Treatment of Diabetic Foot Ulcers Complicated by Osteomyelitis with Gentamicin-Loaded Calcium Sulphate-Hydroxyapatite Biocomposite

2021 ◽  
Vol 10 (2) ◽  
pp. 371
Author(s):  
Kor H. Hutting ◽  
Wouter B. aan de Stegge ◽  
Jaap J. van Netten ◽  
Wouter A. ten Cate ◽  
Luuk Smeets ◽  
...  
Keyword(s):  
Wound Healing ◽  
Surgical Treatment ◽  
Treatment Regimen ◽  
Diabetic Foot ◽  
Prospective Trial ◽  
Calcium Sulphate ◽  
Foot Ulcers ◽  
Ulcer Recurrence ◽  
Diabetic Foot Ulcers ◽  
Cox Regression Analysis

Diabetic foot ulcers, complicated by osteomyelitis, can be treated by surgical resection, dead space filling with gentamicin-loaded calcium sulphate-hydroxyapatite (CaS-HA) biocomposite, and closure of soft tissues and skin. To assess the feasibility of this treatment regimen, we conducted a multicenter retrospective cohort study of patients after failed conventional treatments. From 13 hospitals we included 64 patients with forefoot (n = 41 (64%)), midfoot (n = 14 (22%)), or hindfoot (n = 9 (14%)) ulcers complicated by osteomyelitis. Median follow-up was 43 (interquartile range, 20–61) weeks. We observed wound healing in 54 patients (84%) and treatment success (wound healing without ulcer recurrence) in 42 patients (66%). Treatment failures (no wound healing or ulcer recurrence) led to minor amputations in four patients (6%) and major amputations in seven patients (11%). Factors associated with treatment failures in univariable Cox regression analysis were gentamicin-resistant osteomyelitis (hazard ratio (HR), 3.847; 95%-confidence interval (CI), 1.065–13.899), hindfoot ulcers (HR, 3.624; 95%-CI, 1.187–11.060) and surgical procedures with gentamicin-loaded CaS-HA biocomposite that involved minor amputations (HR, 3.965; 95%-CI, 1.608–9.777). In this study of patients with diabetic foot ulcers, complicated by osteomyelitis, surgical treatment with gentamicin-loaded CaS-HA biocomposite was feasible and successful in 66% of patients. A prospective trial of this treatment regimen, based on a uniform treatment protocol, is required.

The efficacy of platelet-derived wound healing formula (PDWHF) in diabetic foot ulcers: Revisited

2010 ◽  
Vol 6 (1) ◽  
pp. 93-103
Author(s):  
Hany M Abdel Aziz ◽  
Basim M Zaki ◽  
Nahed S Boughdadi ◽  
Karim El-Lamie ◽  
Ashraf Maher ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers
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