scholarly journals Evaluation of Total Adiponectin, Adipocyte Fatty Acid Binding Protein and Fibroblast Growth Factor 21 Levels in Individuals With Metabolic Syndrome

2014 ◽  
pp. 219-228 ◽  
Author(s):  
D. NOVOTNY ◽  
H. VAVERKOVA ◽  
D. KARASEK ◽  
J. LUKES ◽  
L. SLAVIK ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acid ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Although many studies have investigated the relationships of several adipokines to metabolic syndrome (MetS), the interrelationships of adiponectin (ADP), adipocyte fatty acid binding protein (A-FABP) and fibroblast growth factor 21 (FGF 21) have not been described in detail. We examined 209 asymptomatic dyslipidemic patients divided into MetS+ (n=73) and MetS- (n=136) groups. The aim of study was to evaluate the relationships between observed adipokines, to compare the levels of total ADP, A-FABP and FGF 21 in individuals with and without MetS, and to elucidate the relationships of individual adipokines to lipid parameters, markers of insulin resistance and endothelial hemostatic markers in these groups. In MetS+ group, we found the independent positive association ADP with A-FABP (beta=0.4888, p=0.0382), A-FABP with FGF 21 (beta=0.3811, p=0.0002) and von Willebrand factor (beta=0.4502, p=0.0013), and FGF 21 with A-FABP (beta=0.4422, p=0.0002). Our study has confirmed the well-established risk profile of subjects with MetS, although clinically asymptomatic. MetS+ patients had also lower levels of ADP and higher levels of A-FABP and FGF 21. Our study evaluated the interrelationships of ADP, A-FABP and FGF 21 in asymptomatic dyslipidemic subjects with diagnosis of MetS. Especially strong association between A-FABP and FGF 21 needs to be clarified in further studies.

Serum heart type fatty acid binding protein levels in metabolic syndrome

Endocrine ◽  
2009 ◽  
Vol 36 (3) ◽  
pp. 433-437 ◽  
Author(s):  
Erdem Akbal ◽  
Mustafa Özbek ◽  
Fahri Güneş ◽  
Ömer Akyürek ◽  
Kemal Üreten ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Protein Levels ◽  
Acid Binding Protein

Adipocyte fatty acid-binding protein: A predictive marker of metabolic syndrome

2017 ◽  
Vol 263 ◽  
pp. e202
Author(s):  
Michal Karpisek ◽  
David Stejskal ◽  
Martina Hlozankova ◽  
Viktor Ruzicka
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Protein A ◽  
Predictive Marker ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

The fatty acid binding protein-4 (FABP4) is a strong biomarker of metabolic syndrome and lipodystrophy in HIV-infected patients

2008 ◽  
Vol 199 (1) ◽  
pp. 147-153 ◽  
Author(s):  
Blai Coll ◽  
Anna Cabre ◽  
Carlos Alonso-Villaverde ◽  
Iolanda Lazaro ◽  
Gerard Aragonés ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Plasma concentrations of adipocyte fatty acid binding protein in patients with Cushing's syndrome

2010 ◽  
pp. 963-971
Author(s):  
V Ďurovcová ◽  
J Marek ◽  
V Hána ◽  
M Matoulek ◽  
V Zikán ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Plasma Concentrations ◽  
Resting Energy Expenditure ◽  
Hdl Cholesterol ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Simple Obesity

Serum adipocyte fatty acid-binding protein (FABP-4) concentrations are linked to human obesity and other features of metabolic syndrome. Patients with Cushing´s syndrome (CS) develop numerous features of metabolic syndrome due to chronic cortisol excess. Here we tested the hypothesis that chronically increased cortisol levels in CS patients may alter circulating levels of FABP-4. Fourteen patients with CS, 19 patients with simple obesity (OB) and 36 healthy control subjects (C) were included in the study. Serum FABP-4 concentrations were significantly higher in both CS and OB patients relative to C group, but they did not differ between CS and OB groups. In a combined population of all groups, serum FABP-4 levels correlated positively with BMI, body fat content, serum glucose, triglycerides, HbA1c and HOMA index and were inversely related to HDL-cholesterol, resting energy expenditure and freeT3 levels. We conclude that FABP-4 levels are significantly increased in both patients with simple obesity and obese patients with Cushing´s syndrome. We suggest that increased FABP-4 concentrations in CS patients are rather due to their excessive fat accumulation and related metabolic abnormalities than due to a direct effect of cortisol on FABP-4 production.

scholarly journals Association of Intestinal Fatty Acid Binding Protein (FABP2) Polymorphism with Metabolic Syndrome Risk

2018 ◽  
Vol 50 (1) ◽  
Author(s):  
Muhammad Saqlain ◽  
Humaira Kalsoom ◽  
Muhammad Fiaz ◽  
Abid Mahmood ◽  
Rizwan Aziz Qazi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein
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