scholarly journals Aerobic Exercise of Low to Moderate Intensity Corrects Unequal Changes in BKCa Subunit Expression in the Mesenteric Arteries of Spontaneously Hypertensive Rats

2017 ◽  
pp. 219-233 ◽  
Author(s):  
Y. ZHANG ◽  
Y. CHEN ◽  
L. ZHANG ◽  
N. LU ◽  
L. SHI
Keyword(s):  
Aerobic Exercise ◽  
Spontaneously Hypertensive Rats ◽  
Exercise Group ◽  
Mesenteric Arteries ◽  
Moderate Intensity ◽  
Hypertensive Rats ◽  
Bkca Channels ◽  
Spontaneously Hypertensive ◽  
Low Intensity ◽  
L 14

Accumulating evidence indicates that hypertension is associated with “ion channel remodeling” of vascular smooth muscle cells (VSMCs). The objective of this study was to determine the effects of exercise intensity/volume on hypertension-associated changes in large-conductance Ca2+-activated K+ (BKCa) channels in mesenteric arteries (MAs) from spontaneously hypertensive rats (SHR). Male SHRs were randomly assigned to three groups: a low-intensity aerobic exercise group (SHR-L: 14 m/min), a moderate-intensity aerobic exercise group (SHR-M: 20 m/min), and a sedentary group (SHR). Age-matched Wistar-Kyoto rats (WKYs) were used as normotensive controls. Exercise groups completed an 8-week exercise program. Elevation of the α and β1 proteins was unequal in MA myocytes from SHRs, with the β1 subunit increasing more than the α subunit. BKCa contribution to vascular tone regulation was higher in the myocytes and arteries of SHRs compared to WKYs. SHR BKCa channel subunit protein expression, β1/α ratio, whole cell current density and single-channel open probability was also increased compared with WKYs. Aerobic exercise lowered systemic blood pressure and normalized hypertension-associated BKCa alterations to normotensive control levels in the SHRs. These effects were more pronounced in the moderate-intensity group than in the low-intensity group. There is a dose-effect for aerobic exercise training in the range of low to moderate-intensity and accompanying volume for the correction of the pathological adaptation of BKCa channels in myocytes of MAs from SHR.

scholarly journals Low‐intensity aerobic exercise improves cardiac remodelling of adult spontaneously hypertensive rats

2019 ◽  
Vol 23 (9) ◽  
pp. 6504-6507 ◽  
Author(s):  
Luana U. Pagan ◽  
Ricardo L. Damatto ◽  
Mariana J. Gomes ◽  
Aline R. R. Lima ◽  
Marcelo D. M. Cezar ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Spontaneously Hypertensive Rats ◽  
Cardiac Remodelling ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Low Intensity

scholarly journals Aerobic Exercise Upregulates DNA Methylation of Agtr1a and Mas1 Genes to Improve Mesenteric Arterial Function in Spontaneously Hypertensive Rats

2021 ◽  
Author(s):  
Yu Chen ◽  
Shanshan Li ◽  
Zhaoxia Xu ◽  
Yanyan Zhang ◽  
Huirong Zhang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Protein Expression ◽  
Aerobic Exercise ◽  
Vascular Function ◽  
Spontaneously Hypertensive Rats ◽  
Mesenteric Arteries ◽  
Angiotensin Receptors ◽  
Ang Ii ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Abstract The imbalance between vasoconstrictive axis and vasodilative axis of the renin-angiotensin system (RAS) is involved in the pathogenesis of hypertension. Exercise modulates components of the RAS and influences vascular function. This study aimed to investigate the balance of RAS axes and the mechanism of DNA methylation of the Agtr1a (AT1aR) and Mas1 (MasR) genes in aerobic exercise-induced improvement of the function of mesenteric arteries (MAs) in hypertension. Spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats were subjected to exercise training or kept sedentary. Plasma RAS peptides, vascular function, and molecular properties were assessed. Aerobic exercise significantly decreased blood pressure in SHR. Plasma levels of RAS peptides increased in SHR, and the level of Ang II was much higher than Ang-(1–7), whereas exercise efficiently inhibited this inappropriate increase. In addition, Ang II-induced maximal contraction of MAs is largely through Type 1 angiotensin receptors (AT1R), while Mas receptor (MasR) inhibits this contribution. Exercise effectively suppressed hypertension-associated mRNA and protein expression upregulation of AT1R and MasR and increased MasR/AT1R ratio in SHR by triggering hypermethylation of Agtr1a and Mas1 genes, with increasing DNMT1 and DNMT3b protein expression and ratio of SAM/SAH. These findings suggest that aerobic exercise alleviates vascular tone by upregulating the methylation status of the Agtr1a and Mas1 genes and inhibiting the imbalanced increase in the vasoconstrictive and vasodilative axes during hypertension.

The effect of moderate-intensity exercise on the expression of HO-1 mRNA and activity of HO in cardiac and vascular smooth muscle of spontaneously hypertensive rats

2016 ◽  
Vol 94 (4) ◽  
pp. 448-454 ◽  
Author(s):  
Cailing Ren ◽  
Jie Qi ◽  
Wanwei Li ◽  
Jun Zhang
Keyword(s):  
Blood Pressure ◽  
Cardiac Muscle ◽  
Spontaneously Hypertensive Rats ◽  
Exercise Group ◽  
Moderate Intensity ◽  
Control Group ◽  
Hypertensive Rats ◽  
Moderate Intensity Exercise ◽  
Spontaneously Hypertensive ◽  
Sedentary Group

The objective of this study was to observe the effects of moderate-intensity training on the activity of heme oxygenase (HO) and expression of HO-1 mRNA in the aorta and the cardiac muscle of spontaneously hypertensive rats (SHRs). After 9 weeks of swimming exercise, the activity of HO and expression of HO-1 mRNA in the SHRs were measured. The resting blood pressure in the exercise group was increased by 1.7% (P > 0.05), whereas it was significantly elevated by 10.3% (P < 0.01) in the SHR rats. Compared with animals in the control and sedentary groups, the expression level of HO-1 mRNA of aorta and cardiac muscle in the exercise group was significantly enhanced (P < 0.01). The HO activity and the content of plasma carbon monoxide (CO) in the sedentary group were dramatically decreased (P < 0.05 and P < 0.01, respectively) compared with the control group. HO activity and content of plasma CO in the exercise group were significantly higher compared with those in the sedentary group (P < 0.05 and P < 0.01, respectively). The HO/CO metabolic pathway might be involved in the regulation of blood pressure of the SHR models.

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