scholarly journals Low‐intensity aerobic exercise improves cardiac remodelling of adult spontaneously hypertensive rats

2019 ◽  
Vol 23 (9) ◽  
pp. 6504-6507 ◽  
Author(s):  
Luana U. Pagan ◽  
Ricardo L. Damatto ◽  
Mariana J. Gomes ◽  
Aline R. R. Lima ◽  
Marcelo D. M. Cezar ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Spontaneously Hypertensive Rats ◽  
Cardiac Remodelling ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Low Intensity

scholarly journals Aerobic Exercise of Low to Moderate Intensity Corrects Unequal Changes in BKCa Subunit Expression in the Mesenteric Arteries of Spontaneously Hypertensive Rats

2017 ◽  
pp. 219-233 ◽  
Author(s):  
Y. ZHANG ◽  
Y. CHEN ◽  
L. ZHANG ◽  
N. LU ◽  
L. SHI
Keyword(s):  
Aerobic Exercise ◽  
Spontaneously Hypertensive Rats ◽  
Exercise Group ◽  
Mesenteric Arteries ◽  
Moderate Intensity ◽  
Hypertensive Rats ◽  
Bkca Channels ◽  
Spontaneously Hypertensive ◽  
Low Intensity ◽  
L 14

Accumulating evidence indicates that hypertension is associated with “ion channel remodeling” of vascular smooth muscle cells (VSMCs). The objective of this study was to determine the effects of exercise intensity/volume on hypertension-associated changes in large-conductance Ca2+-activated K+ (BKCa) channels in mesenteric arteries (MAs) from spontaneously hypertensive rats (SHR). Male SHRs were randomly assigned to three groups: a low-intensity aerobic exercise group (SHR-L: 14 m/min), a moderate-intensity aerobic exercise group (SHR-M: 20 m/min), and a sedentary group (SHR). Age-matched Wistar-Kyoto rats (WKYs) were used as normotensive controls. Exercise groups completed an 8-week exercise program. Elevation of the α and β1 proteins was unequal in MA myocytes from SHRs, with the β1 subunit increasing more than the α subunit. BKCa contribution to vascular tone regulation was higher in the myocytes and arteries of SHRs compared to WKYs. SHR BKCa channel subunit protein expression, β1/α ratio, whole cell current density and single-channel open probability was also increased compared with WKYs. Aerobic exercise lowered systemic blood pressure and normalized hypertension-associated BKCa alterations to normotensive control levels in the SHRs. These effects were more pronounced in the moderate-intensity group than in the low-intensity group. There is a dose-effect for aerobic exercise training in the range of low to moderate-intensity and accompanying volume for the correction of the pathological adaptation of BKCa channels in myocytes of MAs from SHR.

Aerobic exercise training improves oxidative stress and ubiquitin proteasome system activity in heart of spontaneously hypertensive rats

2015 ◽  
Vol 402 (1-2) ◽  
pp. 193-202 ◽  
Author(s):  
Luiz Henrique Soares de Andrade ◽  
Wilson Max Almeida Monteiro de Moraes ◽  
Eduardo Hiroshi Matsuo Junior ◽  
Elizabeth de Orleans Carvalho de Moura ◽  
Hanna Karen Moreira Antunes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Spontaneously Hypertensive Rats ◽  
Ubiquitin Proteasome System ◽  
Aerobic Exercise Training ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
System Activity ◽  
Ubiquitin Proteasome
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