Drug Carriers With Star Polymer Structures

In this review we summarize several synthetic approaches to the advanced synthesis of star-like polymer-based drug carriers. Moreover, their application as nanomedicines for therapy or the diagnosis of neoplastic diseases and their biodistribution are reviewed in detail. From a broad spectrum of star-like systems, we focus only on fully water-soluble systems, mainly based on poly(ethylene glycol) or N-(2-hydroxypropyl)methacrylamide polymer and copolymer arms and polyamidoamine dendrimers serving as the core of the star-like systems.

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Water-soluble star polymers with a phthalocyanine as the core and poly(ethylene glycol) chains as branches

Journal of Applied Polymer Science ◽

10.1002/app.36631 ◽

2012 ◽

Vol 126 (4) ◽

pp. 1359-1368 ◽

Cited By ~ 10

Author(s):

Placido Mineo ◽

Rossana Alicata ◽

Norberto Micali ◽

Valentina Villari ◽

Emilio Scamporrino

Keyword(s):

Ethylene Glycol ◽

Star Polymers ◽

Water Soluble ◽

Poly Ethylene Glycol ◽

The Core ◽

Poly Ethylene

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Water-soluble dendrimer-poly(ethylene glycol) starlike conjugates as potential drug carriers

Journal of Polymer Science Part A Polymer Chemistry ◽

10.1002/(sici)1099-0518(19990901)37:17<3492::aid-pola7>3.0.co;2-0 ◽

1999 ◽

Vol 37 (17) ◽

pp. 3492-3503 ◽

Cited By ~ 98

Author(s):

Mingjun Liu ◽

Kenji Kono ◽

Jean M. J. Fr�chet

Keyword(s):

Ethylene Glycol ◽

Drug Carriers ◽

Water Soluble ◽

Potential Drug ◽

Poly Ethylene Glycol ◽

Poly Ethylene

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Synthesis of Poly(ethylene glycol) Block Copolymers as Potential Water-Soluble Drug Carriers

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19951765 ◽

1995 ◽

Vol 60 (10) ◽

pp. 1765-1780 ◽

Cited By ~ 11

Author(s):

Michal Pechar ◽

Jiří Strohalm ◽

Karel Ulbrich

Keyword(s):

Block Copolymers ◽

Ethylene Glycol ◽

Glutamic Acid ◽

Drug Carrier ◽

Drug Carriers ◽

Water Soluble ◽

Poly Ethylene Glycol ◽

Water Soluble Drug ◽

Poly Ethylene ◽

The Relationship

The synthesis of a model water-soluble drug carrier based on poly(ethylene glycol) (PEG) block copolymers is described. In the copolymers, two blocks of PEG are linked by a biodegradable oligopeptide or amino acid linkage containing the glutamic acid residue. 4-Nitroaniline as a drug model is attached to the γ-carboxyl group of glutamic acid of the polymer carrier via an enzymatically degradable oligopeptide spacer. The oligopeptides used were potential substrates for chymotrypsin. The relationship between the structure of oligopeptides linking two PEG blocks and the rate of chymotrypsin-catalyzed polymer chain degradation as well as the relationship between the structure of the spacer and kinetics of drug model release from the carrier after incubation in chymotrypsin solution is discussed in detail. The results showed that by modifying the structure of oligopeptides in the polymer construct, changes in the rates of both polymer degradation and the drug model release can be achieved in a very broad range.

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