Synthesis of Poly(ethylene glycol) Block Copolymers as Potential Water-Soluble Drug Carriers

1995 ◽  
Vol 60 (10) ◽  
pp. 1765-1780 ◽  
Author(s):  
Michal Pechar ◽  
Jiří Strohalm ◽  
Karel Ulbrich
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
Water Soluble Drug ◽  
Poly Ethylene ◽  
The Relationship

The synthesis of a model water-soluble drug carrier based on poly(ethylene glycol) (PEG) block copolymers is described. In the copolymers, two blocks of PEG are linked by a biodegradable oligopeptide or amino acid linkage containing the glutamic acid residue. 4-Nitroaniline as a drug model is attached to the γ-carboxyl group of glutamic acid of the polymer carrier via an enzymatically degradable oligopeptide spacer. The oligopeptides used were potential substrates for chymotrypsin. The relationship between the structure of oligopeptides linking two PEG blocks and the rate of chymotrypsin-catalyzed polymer chain degradation as well as the relationship between the structure of the spacer and kinetics of drug model release from the carrier after incubation in chymotrypsin solution is discussed in detail. The results showed that by modifying the structure of oligopeptides in the polymer construct, changes in the rates of both polymer degradation and the drug model release can be achieved in a very broad range.

Y-shaped block copolymer (methoxy-poly(ethylene glycol))2-b-poly(l-glutamic acid): preparation, self-assembly, and use as drug carriers

RSC Advances ◽  
2014 ◽  
Vol 4 (78) ◽  
pp. 41588-41596 ◽  
Author(s):  
Lixin Yang ◽  
Xiuli Hu ◽  
Weiqi Wang ◽  
Shi Liu ◽  
Tingting Sun ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Solid Tumors ◽  
Self Assembly ◽  
Drug Carriers ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Polymer Drugs

The nano polymer drugs based on Y-shaped block copolymer mPEG2-PGA show a great potential on the treatment for solid tumors.

Influence of racemization on stereocomplex-induced gelation of water-soluble polylactide-poly(ethylene glycol) block copolymers

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Helene Nouailhas ◽  
Feng Li ◽  
Abdelsalm El Ghzaoui ◽  
Suming Li ◽  
Jean Coudane
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Poly(L-glutamic acid)-co-poly(ethylene glycol) block copolymers for protein conjugation

2020 ◽  
Vol 324 ◽  
pp. 228-237 ◽  
Author(s):  
Katia Maso ◽  
Antonella Grigoletto ◽  
Lucia Raccagni ◽  
Marino Bellini ◽  
Ilaria Marigo ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Protein Conjugation ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Nano-Sized Micelles of Block Copolymers of Methoxy Poly(ethylene glycol)-Poly(ε-caprolactone)-Graft-2-Hydroxyethyl Cellulose for Doxorubicin Delivery

2008 ◽  
Vol 8 (5) ◽  
pp. 2362-2368 ◽  
Author(s):  
Ming-Fa Hsieh ◽  
Nguyen Van Cuong ◽  
Chao-Hsuan Chen ◽  
Yung Tsung Chen ◽  
Jui-Ming Yeh
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Water Soluble ◽  
Hydroxyethyl Cellulose ◽  
Drug Resistant ◽  
Wild Type ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Mcf 7 ◽  
Resistant Cells

The amphiphilic block copolymers methoxy poly(ethylene glycol)-poly(ε-caprolactone) was grafted to 2-hydroxyethyl cellulose to produce the water-soluble copolymers. Doxorubicin loaded nanoparticles were prepared by dialysis method and the sizes of nanoparticles were determined by dynamic light scattering in solution and atomic force microscopes. As results the sizes were detected in a range of 197.4 to 340.7 nm. The in-vitro release of Dox was studied in phosphate and acetate buffered solution at 37 °C. The results showed that 43 and 53% of Dox remained after an incubation period of 7 days. The cytotoxicity of Dox loaded micelles was investigated in two different human MCF-7/wild type and MCF-7/Adriamycin drug resistant cells lines. The Dox-loaded micelles showed reduced cytotoxicity compared to free Dox in MCF-7/wild type and MCF-7/Adriamycin drug resistant cells.

scholarly journals Polypeptides Micelles Composed of Methoxy-Poly(Ethylene Glycol)-Poly(l-Glutamic Acid)-Poly(l-Phenylalanine) Triblock Polymer for Sustained Drug Delivery

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 230 ◽  
Author(s):  
Xingzheng Liu ◽  
Rongrong Fan ◽  
Boting Lu ◽  
Yuan Le
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Drug Carrier ◽  
Drug Loading ◽  
Poly Ethylene Glycol ◽  
Sustained Drug Release ◽  
Poly Ethylene ◽  
Triblock Polymers

Methoxy-poly(ethylene glycol)-poly(l-glutamic acid)-poly(l-phenylalanine) triblock polymers with different architecture were synthesized as drug carrier to obtain sustained and controlled release by tuning the composition. These triblock polymers were prepared by ring opening polymerization and poly(ethylene glycol) was used as an initiator. Polymerization was confirmed by 1H NMR, FT-IR and gel penetration chromatography. The polymers can self-assemble to form micelles in aqueous medium and their critical micelle concentrations values were examined. The micelles were spherical shape with size of 50–100 nm and especially can arranged in a regular manner. Sorafenib was selected as the model drug and the drug loading performance was dependent on the composition of the block copolymer. In vitro drug release indicated that the polymers can realize controlled and sustained drug release. Furthermore, in vitro cytotoxicity assay showed that the polymers were biocompatible and the drug-loaded micelles can increase toxicity towards tumor cells. Confocal fluorescence microscopy assays illustrated that the micelles can be uptaken quickly and release drug persistently to inhibit tumor cell growth.

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