scholarly journals Determination of Benzoic Acid, Sorbic Acid and Dehydroacetic Acid in Margarine by High Performance Liquid Chromatography

1985 ◽  
Vol 26 (4) ◽  
pp. 385-388_1
Author(s):  
Chiaki MURAKAMI ◽  
Takenori MARUYAMA ◽  
Isao NIIYA
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Benzoic Acid ◽  
High Performance ◽  
Sorbic Acid ◽  
Dehydroacetic Acid

scholarly journals Low-level Determination of 4-Hydrazino BenzoicAcid in Drug Substance by High Performance Liquid Chromatography/Mass Spectrometry

2010 ◽  
Vol 7 (2) ◽  
pp. 403-408 ◽  
Author(s):  
S. Harikrishna ◽  
K. Nagabhushana Reddy ◽  
Y. Suresh ◽  
M. Ramakrishna ◽  
M. Sarat ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Benzoic Acid ◽  
High Performance ◽  
Liquid Chromatography Mass Spectrometry ◽  
Monitoring Methods ◽  
Drug Substances ◽  
Ppm Level

HPLC/MS single ion monitoring methods have been evaluated for the determination of trace levels of 4- hydrazino benzoic acid (4-HBA) in drug substances. These 4-HBA have been highlighted as potential genotoxins. HPLC/MS was found to be more promising and limits of quantification was 0.52 ppm. For one drug substances excellent recoveries of 104.6% were obtained at the 0.5 ppm level.

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