scholarly journals The studying of bioecological features of saffron (Crocus sativus L.) in Nakhchivan Autonomous Republic

2019 ◽  
Vol 5 (3) ◽  
pp. 22-26
Author(s):  
T. Pashayev ◽  
I. Mammadov
Keyword(s):  
Economic Efficiency ◽  
Scientific Research ◽  
Crocus Sativus ◽  
Water Conditions ◽  
Feeding Area ◽  
Biological Development ◽  
First Time ◽  
Autonomous Republic ◽  
Different Altitudes ◽  
Crocus Sativus L

The article provides information about introduction to Nakhchivan AR and first cultivation of saffron (Crocus sativus L.). For the first time the scientific research works were carried out for to study biological development characteristics and economic indicators of planting saffron in Nakhchivan. Searching for new regions and cultivating large areas for partial repayment of our country’s need for this plant is one of today’s important issues. For this purpose, small quantities of bulbs from Bilgah saffron factory were planted in Nakhchivan Autonomous Republic, and scientific research was started. Experiments have been made to study the effect of the depth of planting, the irradiation and sowing times, the irrigation and water conditions on biological development, flowering and productivity of saffron. Onions of all sizes are planted at depths of 5, 10, 15, 20 cm, keeping 60×10 cm feeding area. All experiments were conducted of the four periods at 15 June, 15 July, 15 August and 1 September with 100 onions in each option. Based on the results of the researches, it is possible to say with confidence that the saffron can be adapted to the sharp continental climat of Nakhchivan Autonomous Republic and can be planted and grown at different altitudes of the region. Given the high profitability and economic efficiency, we believe that the establishment of saffron plantations in the Autonomous Republic will be very important.

scholarly journals Development of New Extracts of Crocus sativus L. By-Product from Two Different Italian Regions as New Potential Active Ingredient in Cosmetic Formulations

Cosmetics ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 51
Author(s):  
Maria Rosa Gigliobianco ◽  
Manuela Cortese ◽  
Dolores Vargas Peregrina ◽  
Carla Villa ◽  
Giulio Lupidi ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Skin Irritation ◽  
Sodium Dodecyl ◽  
Water Extract ◽  
Crocus Sativus ◽  
Green Solvents ◽  
Biological Potential ◽  
Italian Regions ◽  
First Time ◽  
Crocus Sativus L

This project aimed to apply eco-friendly extraction methods to Crocus sativus L. by-product (flowers without stigmas i.e., tepals composed of petals and sepals) to recover extracts with high antioxidant capacity and polyphenol content, to be used in cosmetic products. Flowers grown in two different Italian regions (Sample 1—Alba in Piemonte, north of Italy and Sample 2—Sibillini in Marche, centre of Italy) were subjected for the first time to different eco-friendly microwave-mediated green solvents extractions (MGSE) andquali-quantitative determination in antioxidant molecules. Firstly, the extracts from Sample 1 were selected according to their total phenol content (TPC) by Folin–Ciocalteu’s assay and antioxidant capacity (AC) by spectrophotometric assays. Then, according to preliminary results, MGSE carried out in ethanol 70°, water, and glycerin were selected as the most performing methods and applied to both Samples 1 and 2. The best results were obtained using green solvents, such as water or ethanol 70°, for the samples coming from Marche. The identification and quantification of phenolic compounds, belonging to anthocyanins and flavonols classes, was performed by using UPLC-DAD-ESI-MS. Concerning flavonols content, the most abundant analyte is kaempferol 3-O-sophoroside and the extract in water from Sample 1 showed the higher amount of flavonols, reaching the concentration of 25.35 mg of kaempferol 3-O-glucoside equivalent per gram of tepals DW of raw material. Among anthocyanins, the most abundant was delphinidin 3,5-O-diglucoside and the high concentration of anthocyanin was detected in water and ethanol extract. Two new compounds, myricetin-di-glucoside and primflasine, were identified for the first time in Crocus sativus L. by-product by high-resolution mass spectrometry (HRMS). The green batches obtained by extraction were thus characterized and evaluated for their biological potential and safety in keratinocyte HaCaT cells. The extracts were not cytotoxic up to 0.03 mg/mL. The water and ethanol 70° extracts were the most effective in counteracting oxidative stress induced by H2O2 and UVA exposure and reduced cytotoxicity induced by UVB exposure. The water extract was also able to significantly reduce cytotoxicity induced by sodium dodecyl sulphate-induced damage. Taken together, these results suggest a potential use of these waste materials as cosmeceutical preparations such as antiaging, and as anti-skin irritation formulation by-products.

Neuentwicklung einer HPLC-Methode zur Qualitätskontrolle von Safran (Crocus sativus L.)

2016 ◽  
Vol 37 (S 01) ◽  
Author(s):  
K Kuchta ◽  
HH Jin ◽  
RW Wang ◽  
HH He ◽  
L Fang ◽  
...  
Keyword(s):  
Crocus Sativus ◽  
Crocus Sativus L

Biotechnological Studies in Saffron (Crocus sativus L.) Plant

2017 ◽  
Vol 7 (2) ◽  
pp. 343-352
Author(s):  
YONCA SURGUN ACAR ◽  
RABİA İŞKİL ◽  
BETÜL BÜRÜN
Keyword(s):  
Crocus Sativus ◽  
Crocus Sativus L

A Novel Scheme for the Synthesis of 21-Acetoxypregna-1,4,9(11)-triene- 17α,21-diol-3,20-dione from 9α-Hydroxyandrostenedione

2020 ◽  
Vol 16 (5) ◽  
pp. 606-610
Author(s):  
Nguyen T. Diep ◽  
Luu D. Huy
Keyword(s):  
Double Bond ◽  
Chemical Synthesis ◽  
Economic Efficiency ◽  
Final Stage ◽  
Side Chain ◽  
Entire Process ◽  
Drug Synthesis ◽  
First Time

Background: Vietnam currently imports up to 90% of the pharmaceuticals it consumes and 100% of the steroid-based pharmaceuticals. The ability for efficient chemical synthesis of the steroids could create commercial opportunities to address this issue. Synthesis of 21-acetoxypregna-1,4,9(11)- triene-17α,21-diol-3,20-dione is considered a key intermediate in the scheme of steroidal drug synthesis. Previous synthesis attempts of such steroids (corticoids) introduce a double bond at C-1(2) in the final stage of synthesis, which delivers a poor yield and reduces the economic efficiency of the process. Objective: To study and develop a novel and effective method for the synthesis of 21-acetoxypregna- 1,4,9(11)-triene-17α,21-diol-3,20-dione. Methods: Using 9α-hydroxyandrostenedione as a substrate chemical synthesis was performed as follows: pregnane side chain construction at C-17 (acetylene method), introduction of C-1(2) double bond (using SeO2), epimerization of C-17 (via 17-ONO2 ester) and Stork’s iodination. Results: 21-acetoxypregna-1,4,9(11)-triene-17α,21-diol-3,20-dione was prepared from 9α- hydroxyandrostenedione with an improved yield compared to previous attempts. Conclusion: Here, 21-acetoxypregna-1,4,9(11)-triene-17α,21-diol-3,20-dione has been synthesized from 9α-hydroxyandrostenedione based on a novel, effective and commercially feasible scheme. The introduction of the C-1(2) double bond at an earlier stage of the synthesis has increased the economic efficiency of the entire process. For the first time, the indirect epimerization mechanism has been clarified along with the configuration of the C-17 stereo-center which has been confirmed using NOESY data.

Anti-toxicant Properties of Saffron and Relevance to Protection from Toxins and Drugs

2020 ◽  
Vol 16 (3) ◽  
pp. 265-283
Author(s):  
Kyriaki Hatziagapiou ◽  
George I. Lambrou
Keyword(s):  
Redox Reactions ◽  
Case Reports ◽  
Meta Analysis ◽  
Reactive Oxygen ◽  
Crocus Sativus ◽  
Protective Effects ◽  
Nitrogen Species ◽  
Eligibility Criteria ◽  
Crocus Sativus L

Background: Reactive oxygen species and reactive nitrogen species, which are collectively called reactive oxygen nitrogen species, are inevitable by-products of cellular metabolic redox reactions, such as oxidative phosphorylation in the mitochondrial respiratory chain, phagocytosis, reactions of biotransformation of exogenous and endogenous substrata in endoplasmic reticulum, eicosanoid synthesis, and redox reactions in the presence of metal with variable valence. Among medicinal plants there is a growing interest in Crocus sativus L. It is a perennial, stemless herb, belonging to Iridaceae family, cultivated in various countries such as Greece, Italy, Spain, Israel, Morocco, Turkey, Iran, India, China, Egypt and Mexico. Objective: The present study aims to address the anti-toxicant role of Crocus sativus L. in the cases of toxin and drug toxification. Materials and Methods: An electronic literature search was conducted by the two authors from 1993 to August 2017. Original articles and systematic reviews (with or without meta-analysis), as well as case reports were selected. Titles and abstracts of papers were screened by a third reviewer to determine whether they met the eligibility criteria, and full texts of the selected articles were retrieved. Results: The authors focused on literature concerning the role of Crocus Sativus L. as an anti-toxicant agent. Literature review showed that Saffron is a potent anti-toxicant agent with a plethora of applications ranging from anti-oxidant properties, to chemotherapy protective effects. Conclusion: Literature findings represented in current review herald promising results for using Crocus Sativus L. and/or its active constituents as anti-toxicant, chemotherapy-induced protection and toxin protection.

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