scholarly journals Diabetic Nephropathy in Children and Adolescents in the Kyrgyz Republic

2019 ◽  
Vol 5 (4) ◽  
pp. 157-162
Author(s):  
E. Alymbaev ◽  
O. Тerekhova ◽  
G. Maimerova ◽  
G. Kozhonazarova
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Type Diabetes ◽  
Children And Adolescents ◽  
Retrospective Analysis ◽  
Disease Duration ◽  
Kyrgyz Republic ◽  
Case Histories

The article presents a retrospective analysis of case histories of 392 children and adolescents with 1 type diabetes from 2011 to 2018. The analysis found that 60 children and adolescents suffer from diabetic nephropathy (which composes 15%). It was revealed that mostly diabetic nephropathy occurs in boys, as well as disease duration of type 1 diabetes at the time of diagnosis of diabetic nephropathy was 5–10 years.

scholarly journals Influence of Disease Duration on Circulating Levels of miRNAs in Children and Adolescents with New Onset Type 1 Diabetes

2018 ◽  
Author(s):  
Nasim Samandari ◽  
Aashiq H Mirza ◽  
Simranjeet Kaur ◽  
Philip Hougaard ◽  
Lotte Broendum Nielsen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Disease Duration ◽  
Repeated Measurements ◽  
P Value ◽  
First Year ◽  
Immune Mediated ◽  
Remission Phase ◽  
Mirna Expression Profiling

The objective of this study was to identify circulating miRNAs affected by disease duration in newly diagnosed children with type 1 diabetes. Forty children and adolescents from The Danish Remission Phase Cohort were followed with blood samples drawn at 1, 3, 6, 12 and 60 months after diagnosis. Pancreatic autoantibodies were measured at each visit. Cytokines were measured only the first year. miRNA expression profiling was performed by RT-qPCR and quantified for 179 human plasma miRNAs. The effect of disease duration was analyzed by mixed models for repeated measurements, adjusted for sex and age. Eight miRNAs (hsa-miR-10b-5p, hsa-miR-17-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-99a-5p, hsa-miR-125b-5p, hsa-miR-423-3p and hsa-miR-497-5p) were found to significantly change expression (adjusted p-value < 0.05) with disease progression. Three pancreatic autoantibodies ICA, IA-2A, GADA65 and 4 cytokines IL-4, IL-10, IL-21, IL-22 were associated with the miRNAs at different time points. Pathway analysis revealed association with various immune-mediated signaling pathways. Eight miRNAs, involved in immunological pathways changed expression levels during the first five years after diagnosis in children with type 1 diabetes, and were associated with variations in cytokine and pancreatic antibodies, suggesting a possible effect on the immunological processes in the early phase of the disease.

scholarly journals Preclinical diagnosis of diabetic nephropathy in children and adolescents with type 1 diabetes

2011 ◽  
Vol 14 (2) ◽  
pp. 78-81
Author(s):  
Tatiana Petrovna Anikeeva ◽  
Evgeny Ignat'evich Volchanskiy
Keyword(s):  
Blood Flow ◽  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Children And Adolescents ◽  
Vascular Complications ◽  
Hardware System ◽  
Hemodynamic Characteristics ◽  
Patients At Risk ◽  
Arteriolar Tone

Aim. To evaluate the diagnostic and prognostic value of hemodynamic characteristics and endothelial function (EF), viz. endothelium-dependent vasodilation (EDVD) and vasoconstriction (EDVC), during development of diabetic nephropathy (DN). Materials and methods. A total of 155 children and adolescents aged 9-17 years (residents of Volgograd) with type 1 diabetes mellitus (DM1) from 1 to 14 years in duration were examined at the Endocrinological Department of the Regional Childrens Clinical Hospital. The patients were divided into 3 groups depending on DM1 duration. EF and arteriolar tone (AT) were determined by the rheovasographic method. AT was calculated from vascular distension by a pulse wave based on tetrapolar rheovasography of the shoulder and its first derivative. Rheograms were registered using the Valenta software-hardware system. EF was evaluated in a reactive (working) hyperemia test with occlusion of blood vessels in the arm for 4 min followed by decompression; these procedures resulted in an abrupt acceleration of blood flow and endothelium response to shear stress by EDVD. EDVC was determined by occlusion of blood flow in the wrist area that caused its steady decline in the brachial artery and a decrease of its diameter suggesting enhanced vascular tone. Rheovasography was performed during occlusion. Results. Children with DM1 showed enhanced EDVC and impaired EDVD diagnosed before manifestation of microalbuminurea (MAU) characteristic of early DM1. Conclusion. Changes of EF determined from AT, EDVD and EDVC in children with DM1 before manifestation of microalbuminurea make it possible to identify patients at risk of vascular complications.

scholarly journals Protein Intake and Early Diabetic Nephropathy in Children and Adolescents with Type 1 Diabetes † 464

1998 ◽  
Vol 43 ◽  
pp. 82-82
Author(s):  
Bonnie E O'Hayon ◽  
Elizabeth A Cummings ◽  
Marc G Ossip ◽  
Denis Daneman ◽  
Etienne B Sochett
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Children And Adolescents ◽  
Protein Intake ◽  
Early Diabetic Nephropathy

Elevated Urinary VEGF-A,Transferrin, and Angiotensinogen Levels in Normoalbuminuric Children and Adolescents with Type 1 Diabetes; Can They Be Early Markers of Diabetic Kidney Disease?

2021 ◽  
Author(s):  
Aydilek Dağdeviren Çakır ◽  
Seha Kamil Saygılı ◽  
Nur Canpolat ◽  
Dildar Konukoğlu ◽  
Hande Turan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Kidney Disease ◽  
Children And Adolescents ◽  
Diabetic Kidney Disease ◽  
Disease Duration ◽  
Healthy Children ◽  
Diabetic Kidney ◽  
The Mean

Objective: We hypothesized that diabetic kidney disease (DKD) begins early, before albuminuria occurs. We therefore aimed to assess potential early urinary biomarkers of (DKD) in normoalbuminuric and normotensive children and adolescents with Type 1 Diabetes (T1D) to evaluate the relationship between these markers and clinical and laboratory risk factors for DKD. Methods: This cross-sectional study included 75 children and adolescents with T1D (62% females, mean age 13.9 ± 3.2 years) with normoalbuminuria [an albumin/creatinine ratio (ACR) below 30 mg/g creatinine]. Fifty-five age- and sex-matched healthy children and adolescents served as controls. For the assessment of early DKD, urinary levels of angiotensinogen (AGT), transferrin, nephrin, vascular endothelial growth factor-A (VEGF-A), and kidney injury molecule-1 (KIM-1) were measured in adequately collected 24-h urine samples using enzyme-linked immunoassays. Results: The mean disease duration was 7.3± 3.2 (ranged 2.1 - 15.7) years and the mean HbA1c level was 8.8±1.4%. The median levels of urine VEGF-A/Cr, AGT/Cr, and Transferrin/Cr were significantly higher in normoalbuminuric patients with T1D, compared with those of controls (p<0.001, p=0.02, and p=0.001, respectively), but there was no difference in nephrin/Cr and KIM-1/Cr between the two groups. Although, none of the patients had albuminuria, the median level of urine ACR was significantly higher in the patient group than the control group (p=0.003). The ACR was positively correlated with glomerular filtration rate (GFR). Urinary transferrin/Cr, AGT/Cr, and VEGF-A/Cr were significantly correlated with ACR, but not with either GFR or diabetic risk factors including HbA1c or disease duration. Conclusion: Normoalbuminuric and normotensive children and adolescents with T1D have elevated urinary VEGF, AGT and transferrin levels, which may indicate the development of DKD before albuminuria occurs.

scholarly journals MicroRNAs and Risk Factors for Diabetic Nephropathy in Egyptian Children and Adolescents with Type 1 Diabetes

2020 ◽  
Vol Volume 13 ◽  
pp. 2485-2494 ◽  
Author(s):  
Shereen Abdelghaffar ◽  
Hassan Shora ◽  
Sahar Abdelatty ◽  
Fatma Elmougy ◽  
Reham El Sayed ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Children And Adolescents ◽  
Egyptian Children
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