scholarly journals Influence of Disease Duration on Circulating Levels of miRNAs in Children and Adolescents with New Onset Type 1 Diabetes

2018 ◽  
Author(s):  
Nasim Samandari ◽  
Aashiq H Mirza ◽  
Simranjeet Kaur ◽  
Philip Hougaard ◽  
Lotte Broendum Nielsen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Disease Duration ◽  
Repeated Measurements ◽  
P Value ◽  
First Year ◽  
Immune Mediated ◽  
Remission Phase ◽  
Mirna Expression Profiling

The objective of this study was to identify circulating miRNAs affected by disease duration in newly diagnosed children with type 1 diabetes. Forty children and adolescents from The Danish Remission Phase Cohort were followed with blood samples drawn at 1, 3, 6, 12 and 60 months after diagnosis. Pancreatic autoantibodies were measured at each visit. Cytokines were measured only the first year. miRNA expression profiling was performed by RT-qPCR and quantified for 179 human plasma miRNAs. The effect of disease duration was analyzed by mixed models for repeated measurements, adjusted for sex and age. Eight miRNAs (hsa-miR-10b-5p, hsa-miR-17-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-99a-5p, hsa-miR-125b-5p, hsa-miR-423-3p and hsa-miR-497-5p) were found to significantly change expression (adjusted p-value < 0.05) with disease progression. Three pancreatic autoantibodies ICA, IA-2A, GADA65 and 4 cytokines IL-4, IL-10, IL-21, IL-22 were associated with the miRNAs at different time points. Pathway analysis revealed association with various immune-mediated signaling pathways. Eight miRNAs, involved in immunological pathways changed expression levels during the first five years after diagnosis in children with type 1 diabetes, and were associated with variations in cytokine and pancreatic antibodies, suggesting a possible effect on the immunological processes in the early phase of the disease.

scholarly journals Influence of Disease Duration on Circulating Levels of miRNAs in Children and Adolescents with New Onset Type 1 Diabetes

2018 ◽  
Vol 4 (4) ◽  
pp. 35 ◽  
Author(s):  
Nasim Samandari ◽  
Aashiq Mirza ◽  
Simranjeet Kaur ◽  
Philip Hougaard ◽  
Lotte Nielsen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Disease Duration ◽  
Repeated Measurements ◽  
P Value ◽  
Recent Onset ◽  
Onset Type ◽  
Remission Phase ◽  
Mirna Expression Profiling

Circulating microRNAs (miRNAs) have been implicated in several pathologies including type 1 diabetes. In the present study, we aimed to identify circulating miRNAs affected by disease duration in children with recent onset type 1 diabetes. Forty children and adolescents from the Danish Remission Phase Cohort were followed with blood samples drawn at 1, 3, 6, 12, and 60 months after diagnosis. Pancreatic autoantibodies were measured at each visit. Cytokines were measured only the first year. miRNA expression profiling was performed by RT-qPCR. The effect of disease duration was analyzed by mixed models for repeated measurements adjusted for sex and age. Eight miRNAs (hsa-miR-10b-5p, hsa-miR-17-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-99a-5p, hsa-miR-125b-5p, hsa-miR-423-3p, and hsa-miR-497-5p) were found to significantly change in expression (adjusted p-value < 0.05) with disease progression. Three pancreatic autoantibodies, ICA, IA-2A, and GAD65A, and four cytokines, IL-4, IL-10, IL-21, and IL-22, were associated with the miRNAs at different time points. Pathway analysis revealed associations with various immune-mediated signaling pathways. Eight miRNAs that were involved in immunological pathways changed expression levels during the first five years after diagnosis and were associated with variations in cytokine and pancreatic antibodies, suggesting a possible effect on the immunological processes in the early phase of the disease.

scholarly journals Diabetic Nephropathy in Children and Adolescents in the Kyrgyz Republic

2019 ◽  
Vol 5 (4) ◽  
pp. 157-162
Author(s):  
E. Alymbaev ◽  
O. Тerekhova ◽  
G. Maimerova ◽  
G. Kozhonazarova
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Type Diabetes ◽  
Children And Adolescents ◽  
Retrospective Analysis ◽  
Disease Duration ◽  
Kyrgyz Republic ◽  
Case Histories

The article presents a retrospective analysis of case histories of 392 children and adolescents with 1 type diabetes from 2011 to 2018. The analysis found that 60 children and adolescents suffer from diabetic nephropathy (which composes 15%). It was revealed that mostly diabetic nephropathy occurs in boys, as well as disease duration of type 1 diabetes at the time of diagnosis of diabetic nephropathy was 5–10 years.

scholarly journals Influence of the Type of Basal Insulin and Other Variables on Clinical Outcomes in Children with Newly Diagnosed Type 1 Diabetes

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Ruth M. Garrison ◽  
Jeremy L. Johnson ◽  
Michelle E. Condren ◽  
Kevin C. Farmer ◽  
David H. Jelley
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Basal Insulin ◽  
Retrospective Chart Review ◽  
Severe Hypoglycemia ◽  
First Year ◽  
Newly Diagnosed ◽  
Diabetes Clinic ◽  
Pediatric Diabetes

Background. Basal insulin detemir and glargine each have characteristics that may make them a superior choice in children and adolescents with type 1 diabetes, but there is a paucity of data on glycemic results in this population. Objective. Examination of variables associated with achievement of HbA1c goal in children and adolescents with newly diagnosed type 1 diabetes. Methods. The primary outcome, factors associated with achievement of HbA1c goal, was examined in a retrospective chart review. Variables, including type of basal insulin, were collected during the first year of diagnosis of patients in a pediatric diabetes clinic. Secondary outcomes included change in HbA1c, severe hypoglycemic events, and episodes of DKA. Results. 94 patients were included in the study. HbA1c at diagnosis was found to be a significant predictor of achievement of goal at 3 months (P=0.002) and of change in HbA1c at 3 and 12 months (P<0.001 for each). Severe hypoglycemia and episodes of DKA were uncommon. Conclusions. Choice of basal insulin was not found to be a predictor of achieving HbA1c goal or of change in HbA1c over the course of the first year of diagnosis with type 1 diabetes.

Decline of C-peptide during the first year after diagnosis of Type 1 diabetes in children and adolescents

2013 ◽  
Vol 100 (2) ◽  
pp. 203-209 ◽  
Author(s):  
Johnny Ludvigsson ◽  
Annelie Carlsson ◽  
Ahmed Deli ◽  
Gun Forsander ◽  
Sten-A. Ivarsson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
First Year ◽  
C Peptide

Elevated Urinary VEGF-A,Transferrin, and Angiotensinogen Levels in Normoalbuminuric Children and Adolescents with Type 1 Diabetes; Can They Be Early Markers of Diabetic Kidney Disease?

2021 ◽  
Author(s):  
Aydilek Dağdeviren Çakır ◽  
Seha Kamil Saygılı ◽  
Nur Canpolat ◽  
Dildar Konukoğlu ◽  
Hande Turan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Kidney Disease ◽  
Children And Adolescents ◽  
Diabetic Kidney Disease ◽  
Disease Duration ◽  
Healthy Children ◽  
Diabetic Kidney ◽  
The Mean

Objective: We hypothesized that diabetic kidney disease (DKD) begins early, before albuminuria occurs. We therefore aimed to assess potential early urinary biomarkers of (DKD) in normoalbuminuric and normotensive children and adolescents with Type 1 Diabetes (T1D) to evaluate the relationship between these markers and clinical and laboratory risk factors for DKD. Methods: This cross-sectional study included 75 children and adolescents with T1D (62% females, mean age 13.9 ± 3.2 years) with normoalbuminuria [an albumin/creatinine ratio (ACR) below 30 mg/g creatinine]. Fifty-five age- and sex-matched healthy children and adolescents served as controls. For the assessment of early DKD, urinary levels of angiotensinogen (AGT), transferrin, nephrin, vascular endothelial growth factor-A (VEGF-A), and kidney injury molecule-1 (KIM-1) were measured in adequately collected 24-h urine samples using enzyme-linked immunoassays. Results: The mean disease duration was 7.3± 3.2 (ranged 2.1 - 15.7) years and the mean HbA1c level was 8.8±1.4%. The median levels of urine VEGF-A/Cr, AGT/Cr, and Transferrin/Cr were significantly higher in normoalbuminuric patients with T1D, compared with those of controls (p<0.001, p=0.02, and p=0.001, respectively), but there was no difference in nephrin/Cr and KIM-1/Cr between the two groups. Although, none of the patients had albuminuria, the median level of urine ACR was significantly higher in the patient group than the control group (p=0.003). The ACR was positively correlated with glomerular filtration rate (GFR). Urinary transferrin/Cr, AGT/Cr, and VEGF-A/Cr were significantly correlated with ACR, but not with either GFR or diabetic risk factors including HbA1c or disease duration. Conclusion: Normoalbuminuric and normotensive children and adolescents with T1D have elevated urinary VEGF, AGT and transferrin levels, which may indicate the development of DKD before albuminuria occurs.

Bone turnover markers during the remission phase in children and adolescents with type 1 diabetes

2019 ◽  
Vol 21 (2) ◽  
pp. 366-376 ◽  
Author(s):  
Jens O. B. Madsen ◽  
Camilla W. Herskin ◽  
Bo Zerahn ◽  
Andreas K. Jensen ◽  
Niklas R. Jørgensen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Bone Turnover ◽  
Children And Adolescents ◽  
Bone Turnover Markers ◽  
Turnover Markers ◽  
Remission Phase

scholarly journals Psychological and behavioral complications in children and adolescents with type 1 diabetes mellitus in Sohag

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Saber Hadad ◽  
Magda Mohamed Ali ◽  
Taher Abdelraheem Sayed
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Conduct Problems ◽  
Emotional Problems ◽  
P Value ◽  
Peer Problems ◽  
Diabetic Children

Abstract Background Type 1 diabetes mellitus is a chronic disease mainly diagnosed in children and adolescents. It has multiple psychiatric comorbidities. Our aim in this study was to determine the prevalence of psychological and behavioral problems in children and adolescents diagnosed with type 1 diabetes and to find if there is a strong correlation between these problems and different epidemiological- and disease-related factors such as age of the child, duration of diabetes, and other risk factors. We conducted a cross-sectional study and compared between 564 children diagnosed with diabetes mellitus type 1 (who attended Specialized Health Insurance Clinic in Sohag City, Upper Egypt, during the year 2018/2020) and 564 non-diabetic children matched with the diabetic children for age, sex, and socio-economic status. We used “Strengths and Difficulties Questionnaire (SDQ)” to screen for behavioral, social, and emotional problems in diabetic and control children. “SDQ” is a 25-item brief behavioral screening questionnaire that consists of five subscales which are emotional problems, hyperactivity-inattention problems, conduct problems, peer problems, and prosocial behavior subscales. It generates total score and individual score for each subscale. Results In our study, we found that diabetic children had significantly higher prevalence of emotional and behavioral problems than control children (92.37% of diabetic children versus 20.2% of control children had abnormal total SDQ score with P value < 0.001). All subscales of SDQ except prosocial subscale were significantly affected in children with type 1 diabetes mellitus than control children with P value < 0.001. Certain factors were significantly associated with impaired subscales of SDQ scale. We found a positive correlation between age and emotional, hyperactivity and conduct problems as these problems were more frequent in older children. Female children had more hyperactivity and conduct problems than male children (68.6%, 71.7% vs. 58.0%, 62.0%, P 0.002 and 0.003, respectively) while male children were more affected by emotional problems than female children (68% vs. 57.4%, P 0.003). Peer problems were more prevalent in children of parents with higher educational level. Children with positive family history of diabetes were less affected by emotional problems than children with negative family history (50% vs.64.3%, P 0.04). Longer duration of disease was associated with increased prevalence of peer and emotional problems. Poor control of diabetes increased the prevalence of conduct and emotional problems (P 0.007 and 0.022, respectively). Conclusion Children with type 1 diabetes mellitus have more emotional, hyperactivity, conduct, and peer problems than non-diabetic children. These findings indicate a need to screen diabetic children and adolescents for behavioral and emotional problems and treat these problems if found.

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