Comprehensive Assessment of the Safety of a New Antituberculosis Drug from the Diarylquinolines Group
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The safety of the new anti-tuberculosis drug Tiozonide was studied by bioinformatics and preclinical methods using laboratory animals and with the participation of healthy volunteers. The absence of toxic effects on the main life support systems of mammals predicted by QSAR models was confi rmed by the results of acute, subchronic and chronic toxicity tests in various laboratory animals. Monitoring of the vital indicators of volunteers and a comparative analysis of the generalized results of these indicators before (screening), during and after the study showed the absence of reliable and clinically signifi cant changes that threaten the life and health of people.
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1990 ◽
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2013 ◽
Vol 2
(3)
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pp. 208-216
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2017 ◽
Vol 29
(3)
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pp. 241-249
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