scholarly journals Phytochemical Screening and Free Radical Scavenging Activity of Cinnamomum tamala Leaf Extract

2021 ◽  
Vol 7 (2) ◽  
Author(s):  
Rani Raksha ◽  
Kumar Rajesh ◽  
Sharma Preeti ◽  
Hajam Younis Ahmad ◽  
Rai Seema
Keyword(s):  
Free Radical ◽  
Leaf Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Scavenging Activity ◽  
Phytochemical Screening ◽  
Bioactive Components ◽  
Cinnamomum Tamala

Traditional plant-based medicines are still needed by the whole world for their primary healthcare benefits. The phytochemicals or plant extract could be used to treat different diseases and new formulation for the drug discovery in pharmaceuticals. Cinnamomum tamala is commonly called as Indian bay leaf or Tejpatta. The leaves and bark of Cinnamomum tamala are used to cure various diseases due to its various properties including astringent, stimulant and carminative. Hence, the objective of this study was to determine the comparative phytochemical screening and free radical scavenging activity of the leaf of Cinnamomum tamala. To achieve this, extract was prepared in three solvents (ethanol, ethanol, aqueous and chloroform). Phytochemical screening (qualitative and quantitative) was evaluated in all the three fractions to compare the solubility of various bioactive components. Phytochemical screening showed the presence of polyphenols, flavonoids, alkaloids, flavones and flavonols, tannins, carbohydrates, amino acids and proteins, saponins and glycosides in leaves of Cinnamomum tamala. Quantitative analysis showed that the total polyphenolic content, total flavonoids content, total alkaloids and total flavones and flavonols content in the hydroalcoholic extract was 48.1 mg GA (gallic acid)/g, 22.1 mg QE (Quercetin)/g, 59.9 mg/g and 1.75 mg RE (Rutin)/g, respectively. DPPH free radical assay revealed that Cinnamomum tamala hydroalcoholic leaf extract at a 100 µm/ml concentration showed 96.99± 0.99% inhibition activity. It can be concluded that most of the bioactive components are found soluble in hydroalcoholic solvent. Cinnamomum tamala hydroalcoholic leaf extract contains various bioactive and also exhibits significant free radical scavenging activity. Hence, it can be used as an alternative remedy for the treatment of various diseases.

scholarly journals Phytochemical Screening and Free Radical Scavenging Activity of Hydroethanolic Leaf Extract of Senna sieberiana DC (Caesalpiniaceae) and its Fractions

2019 ◽  
pp. 1-6
Author(s):  
Alioune Dior Fall ◽  
Awa Ndiaye Sy ◽  
Serigne Ibra Mbacké Dieng ◽  
Abdou Sarr ◽  
Mbaye Dieng
Keyword(s):  
Free Radical ◽  
Ethyl Acetate ◽  
Leaf Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Scavenging Activity ◽  
Phytochemical Screening ◽  
Ic50 Values

Objectives: The aim of this study was to identify the phytochemical groups of hydroethanolic leaf extract of Senna sieberiana DC and its fractions and to investigate their free radical scavenging activity. Methods: S. sieberiana leaves were extracted with hydroethanolic solvent. From the hydroethanolic extract 3 fractions were obtained after a liquid/liquid fractionation (dichloromethane, ethyl acetate and water). Phytochemical screening of the leaf extract and its fractions was done using standard reactions. Free radical scavenging activity was assessed using DPPH and ABTS assays.  Results: Tannins, flavonoids, anthracenic derivatives, sterols and triterpenoids were the main phytochemical constituents of the leaf extract and fractions. The hydro-ethanolic leaf extract of Senna sieberiana, its dichloromethane, ethyl acetate and aqueous fractions and ascorbic acid had respective IC50 values of 191.6±3.82 - 495.73±8.96 - 165.8±4.85 - 50.40±2.65 - 19.53±0.13 µg/ml in ABTS assay.  In DPPH assay,  the IC50 values were  44.8 ± 1.22 - 218.93±9.01 - 32.13 ± 1.8 - 26.4±0.11- 4.66±0.07 µg/ml respectively for the leaf extract, dichloromethane, ethyl acetate and aqueous fractions and ascorbic acid. Conclusion: The hydroethanolic leaf extract of S. sieberiana had shown free radical scavenging activity. The aqueous fraction was more active among plant tested samples. 

scholarly journals Phytochemical Screening, Free Radical Scavenging and α-Amylase Inhibitory Activities of Selected Medicinal Plants from Western Nepal

Medicines ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. 70 ◽  
Author(s):  
Kusum Sai ◽  
Rashmi Thapa ◽  
Hari Prasad Devkota ◽  
Khem Raj Joshi
Keyword(s):  
Free Radical ◽  
Medicinal Plants ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Total Phenolic ◽  
Scavenging Activity ◽  
Phytochemical Screening ◽  
Inhibitory Activities

Background: More than 700 plants are reported to be used for medicinal purposes in Nepal; however, many of them are not studied for their scientific evidences. The aims of the present study were the estimation of the total phenolic and flavonoid contents, and the evaluation of the free radical scavenging and α-amylase inhibitory activities of five selected medicinal plants from western Nepal: Aeschynanthus parviflorus Wall. (Gesneriaceae), Buddleja asiatica Lour. (Loganiaceae), Carica papaya L. (Caricaceae), Drepanostachyum falcatum (Nees) Keng f. (Gramineae) and Spondias pinnata (L. f.) Kurz (Anacardiaceae). Methods: The total phenolic content (TPC) and total flavonoid content (TFC) were measured using Folin-Ciocalteu’s phenol reagent and aluminium chloride methods, respectively. A 1,1–diphenyl–2–picrylhydrazyl (DPPH) free radical scavenging assay was used to evaluate the free radical scavenging activity and an α-amylase inhibitory assay was carried out to determine the in vitro antidiabetic activity. Results: The phytochemical screening of five hydroalcoholic plant extracts revealed the presence of various secondary metabolites, including alkaloids, flavonoids, reducing sugars, saponins, terpenoids and tannins. The amounts of total phenolics and flavonoids were found to be the highest in B. asiatica leaf extract, which also showed the most potent free radical scavenging activity. Extract of C. papaya fruits showed the highest α-amylase inhibitory activity, whereas the extracts of B. asiatica leaves and S. pinnata leaves exhibited moderate activity. Conclusions: Some of the medicinal plants selected in this study showed high TPC and TFC values and potent bioactivities. These results may provide the scientific evidences of the traditional uses of these plants. However, further detailed studies on bioactive compounds isolation and identification and evaluation of in vivo pharmacological activities should be performed in future.

scholarly journals Phytochemical Screening and Free Radical Scavenging Activity of Dialium guineense (Jacq) Fruit Pulp

2018 ◽  
Vol 3 (3) ◽  
pp. 97-103
Author(s):  
Emmanuel Mshelia Halilu ◽  
Millicient Ladi Umaru ◽  
Troy Malgwi Salvia ◽  
Musa Yusuf Dibal ◽  
Abdulrahman Adamu Isah ◽  
...  
Keyword(s):  
Free Radical ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Scavenging Activity ◽  
Fruit Pulp ◽  
Phytochemical Screening

Evaluation of phenolic contents, free radical scavenging activity and functional group analysis of the leaf extract of a medicinal plant in Niger Delta region

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Free Radical ◽  
Niger Delta ◽  
Leaf Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Scavenging Activity ◽  
Delta Region ◽  
Niger Delta Region

Funtumia africana leaves have been used by the people of Niger Delta region of Nigeria to treat diabetes. This study aims to evaluate the polyphenolic contents, antioxidant, and free radical scavenging activities of the leaf crude extract and fractions. The crude aqueous methanolic leaf extract of F. africana was extracted by liquid-liquid partitioning into n-hexane, dichloromethane, ethyl acetate and n-butanol fractions. The free radical scavenging activity of the fractions was measured in vitro by using the ferric-reducing antioxidant power (FRAP), 2, 2-diphenyl-1-picryl dihydrazyl (DPPH), and nitric oxide (NO) assays. Phytochemical screening showed the presence of tannins, saponins, alkaloids, terpenoids, steroids, reducing sugars, cardiac glycosides and flavonoids in the extract and polar fractions. The highest total phenolics, total flavonoids and total antioxidant capacity were found to be 1331.18±41.56 mg GAE/g, 833.96±19.14 mg QUE/g and 83.74±1.88 mgAAE/g respectively in the butanol fraction. The n-hexane and butanol fractions demonstrated strong DPPH scavenging activity with IC50 values of 0.06±0.57 and 0.06±0.5 μg/ml, respectively. The DCM fraction showed the highest NO scavenging activity with IC50 value of 0.741±0.07 mg/ml, while hexane fraction has negligible effect. The butanolic fraction has the highest ferric reducing antioxidant activity with value of 48.46±0.15 mg AAE/g of sample.

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