Thyroid Metabolism in the Recessive Sex-Linked Dwarf Female Chicken

Van Wyk et al. have reported a case of goiter and hypothyroidism in an infant maintained 8 months on a diet of soybean milk (Mull-Soy®). Their studies of this case and comparison with apparently normal individuals have led them to infer the presence in soy of a goitrogen which, in susceptible persons, modifies thyroid metabolism. We are studying the effect of soybean products on thyroid activity in rats and it seems desirable to present certain preliminary observations at this time. Rats, housed in individual wire-screen cages, were fed diets simulating soybean milk in composition and fortified with vitamins and iron to meet the known requirements. Water, ion-exchanged to remove traces of iodine, was provided ad libitum.

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Calcium Homeostasis and Eggshell Biomineralization in Female Chicken

Vitamin D ◽

10.1016/b978-0-12-809965-0.00022-7 ◽

2018 ◽

pp. 361-382 ◽

Cited By ~ 5

Author(s):

Yves Nys ◽

Nathalie Le Roy

Keyword(s):

Calcium Homeostasis ◽

Female Chicken

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Gut Microbiome Alterations in Patients With Thyroid Nodules

Frontiers in Cellular and Infection Microbiology ◽

10.3389/fcimb.2021.643968 ◽

2021 ◽

Vol 11 ◽

Author(s):

Ang Li ◽

Tiantian Li ◽

Xinxin Gao ◽

Hang Yan ◽

Jingfeng Chen ◽

...

Keyword(s):

Gut Microbiota ◽

Gut Microbiome ◽

Thyroid Nodules ◽

Genome Wide Association Study ◽

Adult Population ◽

Lower Grade ◽

High Grade ◽

Microbial Composition ◽

Thyroid Metabolism ◽

Relative Abundances

Thyroid nodules are found in nearly half of the adult population. Accumulating evidence suggests that the gut microbiota plays an important role in thyroid metabolism, yet the association between gut microbiota capacity, thyroid nodules, and thyroid function has not been studied comprehensively. We performed a gut microbiome genome-wide association study in 196 patients with thyroid nodules and 283 controls by using whole-genome shotgun sequencing. We found that participants with high-grade thyroid nodules have decreased number of gut microbial species and gene families compared with those with lower grade nodules and controls. There are also significant alterations in the overall microbial composition in participants with high-grade thyroid nodules. The gut microbiome in participants with high-grade thyroid nodules is characterized by greater amino acid degradation and lower butyrate production. The relative abundances of multiple butyrate producing microbes are reduced in patients with high-grade thyroid nodules and the relative abundances of L-histidine metabolism pathways are associated with thyrotropin-releasing hormone. Our study describes the gut microbiome characteristics in thyroid nodules and a gut-thyroid link and highlight specific gut microbiota as a potential therapeutic target to regulate thyroid metabolism.

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