scholarly journals Identification of myeloid dendritic cells and plasmacytoid dendritic cells in the peripheral blood of rheumatoid arthritis

2013 ◽  
Vol 4 ◽  
Author(s):  
Falaleeva Svetlana ◽  
Kurilin Vasily ◽  
Shkaruba Nadezhda ◽  
Chumasova Oksana ◽  
Sizikov Aleksey ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Dendritic Cells ◽  
Peripheral Blood ◽  
Plasmacytoid Dendritic Cells ◽  
Myeloid Dendritic Cells

AB0450 Myeloid Dendritic Cells and Plasmacytoid Dendritic Cells as Possible Target for the Immunotherapy in Patients with Rheumatoid Arthritis

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 957.1-957
Author(s):  
S.A. Falaleeva ◽  
V.V. Kurilin ◽  
N.S. Shkaruba ◽  
O.A. Chumasova ◽  
A.E. Sizikov ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Dendritic Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Myeloid Dendritic Cells

Longitudinal Peripheral Blood Lymphocyte Subsets Correlate with Decreased Disease Activity in Juvenile Dermatomyositis

2013 ◽  
Vol 40 (7) ◽  
pp. 1200-1211 ◽  
Author(s):  
Floranne C. Ernste ◽  
Cynthia S. Crowson ◽  
Consuelo Lopez de Padilla ◽  
Molly S. Hein ◽  
Ann M. Reed
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Disease Activity ◽  
Nk Cells ◽  
Peripheral Blood ◽  
Juvenile Dermatomyositis ◽  
Plasmacytoid Dendritic Cells ◽  
Myeloid Dendritic Cells ◽  
Hla Dr ◽  
Vas Scores

Objective:To determine the clinical characteristics and subsets of peripheral blood lymphocytes (PBL), which correlate with decreased disease activity in patients with juvenile dermatomyositis (JDM).Methods.Peripheral blood mononuclear cells from 24 patients with JDM were collected at Mayo Clinic Rochester between 2007 and 2011. These were analyzed using fluorescence-activated cell sorting and flow cytometry. Clinical disease activity was determined by visual analog scales (VAS) collected in 2 consecutive visits and correlated with PBL subsets.Results.The change in CD3+CD69+ T cells correlated with the change in global VAS scores. The change in HLA-DR- CD11c+ myeloid dendritic cells also correlated with the change in extramuscular VAS scores. There were trends toward decreased levels of HLA-DR- CD11c+ cells with decreased muscle and global VAS scores, but these did not reach significance. The change in HLA-DR- CD123+ plasmacytoid dendritic cells negatively correlated with the change in muscle VAS scores. Although not statistically significant, decreased levels of CD3-CD16- CD56+ natural killer (NK) cells and HLA-DR- CD86+ myeloid dendritic cells, and increased levels of CD16+CD56- NK cells, correlated with decreased VAS scores.Conclusion.Changes in CD3+CD69+ T cells, HLA-DR- CD11c+ myeloid dendritic cells, and HLA-DR- CD123+ plasmacytoid dendritic cells are associated with improved clinical course in JDM and could be used as markers for disease activity, but findings need to be verified in a larger, independent cohort. Lack of significant differences among most of our PBL subsets suggests that lymphocyte phenotyping may be difficult to definitively correlate with disease activity in JDM.

01.10 Peripheral blood plasmacytoid dendritic cells in early rheumatoid arthritis

2017 ◽  
Author(s):  
Faye AH Cooles ◽  
Amy E Anderson ◽  
Dennis W Lendrem ◽  
Julie Norris ◽  
Arthur G Pratt ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Dendritic Cells ◽  
Early Rheumatoid Arthritis ◽  
Peripheral Blood ◽  
Plasmacytoid Dendritic Cells

Alteration of Balance between Myeloid Dendritic Cells and Plasmacytoid Dendritic Cells in Peripheral Blood of Patients with Asthma

2002 ◽  
Vol 166 (8) ◽  
pp. 1050-1054 ◽  
Author(s):  
Hiroyuki Matsuda ◽  
Takafumi Suda ◽  
Hideo Hashizume ◽  
Koushi Yokomura ◽  
Kazuhiro Asada ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Peripheral Blood ◽  
Plasmacytoid Dendritic Cells ◽  
Myeloid Dendritic Cells

Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome

2009 ◽  
Vol 69 (6) ◽  
pp. 1235-1238 ◽  
Author(s):  
Petra Vogelsang ◽  
Johan G Brun ◽  
Gunnvor Øijordsbakken ◽  
Kathrine Skarstein ◽  
Roland Jonsson ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Sjögren’S Syndrome ◽  
Peripheral Blood ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Healthy Controls ◽  
Myeloid Dendritic Cells ◽  
Antigen Presenting ◽  
Sjögren‘S Syndrome

ObjectiveSjögren's syndrome (SS) is a lymphoproliferative autoimmune disease, characterised by dryness of the mouth and eyes. Dendritic cells (DC) are potent antigen-presenting cells crucial for initiating and maintaining primary immune responses. This study quantified interferon-producing plasmacytoid DC (pDC) and two myeloid DC subsets (mDC1 and mDC2) in peripheral blood (PB) from primary SS (pSS) patients and healthy controls.MethodsBlood samples from 31 pSS patients and 28 gender and age-matched healthy controls were analysed by flow cytometry using the Miltenyi Blood DC enumeration kit. The presence of pDC in salivary glands (SG) from pSS patients was analysed by immunohistochemistry.ResultsPatients with pSS had significantly less pDC and mDC2 in PB compared with healthy controls. Moreover, pDC are present in SG from patients with pSS.ConclusionPatients with pSS have alterations among DC populations in PB, and pDC are present in the SG, suggesting a potential role of these cells in SS.

scholarly journals Activation of Plasmacytoid Dendritic Cells with TLR9 Agonists Initiates Invariant NKT Cell-Mediated Cross-Talk with Myeloid Dendritic Cells

2006 ◽  
Vol 177 (2) ◽  
pp. 1028-1039 ◽  
Author(s):  
Carlos J. Montoya ◽  
Hyun-Bae Jie ◽  
Lena Al-Harthi ◽  
Candice Mulder ◽  
Pablo J. Patiño ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cross Talk ◽  
Plasmacytoid Dendritic Cells ◽  
Myeloid Dendritic Cells ◽  
Nkt Cell ◽  
Invariant Nkt Cell

scholarly journals Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells

2021 ◽  
Vol 22 (15) ◽  
pp. 8349
Author(s):  
Giulio Verna ◽  
Marina Liso ◽  
Elisabetta Cavalcanti ◽  
Giusy Bianco ◽  
Veronica Di Sarno ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Intestinal Barrier ◽  
Plasmacytoid Dendritic Cells ◽  
Myeloid Dendritic Cells ◽  
Soluble Factors ◽  
Secreted Factors ◽  
Mucosal Tissues ◽  
Basolateral Side ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Dendritic cells (DCs) can be divided by lineage into myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs). They both are present in mucosal tissues and regulate the immune response by secreting chemokines and cytokines. Inflammatory bowel diseases (IBDs) are characterized by a leaky intestinal barrier and the consequent translocation of bacterial lipopolysaccharide (LPS) to the basolateral side. This results in DCs activation, but the response of pDCs is still poorly characterized. In the present study, we compared mDCs and pDCs responses to LPS administration. We present a broad panel of DCs secreted factors, including cytokines, chemokines, and growth factors. Our recent studies demonstrated the anti-inflammatory effects of quercetin administration, but to date, there is no evidence about quercetin’s effects on pDCs. The results of the present study demonstrate that pDCs can respond to LPS and that quercetin exposure modulates soluble factors release through the same molecular pathway used by mDCs (Slpi, Hmox1, and AP-1).

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