scholarly journals Allergological Importance of Invertebrate Glutathione Transferases in Tropical Environments

2021 ◽  
Vol 2 ◽  
Author(s):  
Josefina Zakzuk ◽  
Ana Lozano ◽  
Luis Caraballo
Keyword(s):  
Cross Reactivity ◽  
Clinical Impact ◽  
House Dust Mites ◽  
Glutathione Transferases ◽  
Allergic Reactions ◽  
Dust Mites ◽  
Tropical Environments ◽  
Allergenic Activity ◽  
Glutathione S Transferases ◽  
Structural Aspects

Glutathione-S transferases (GSTs) are part of a ubiquitous family of dimeric proteins that participate in detoxification reactions. It has been demonstrated that various GSTs induce allergic reactions in humans: those originating from house dust mites (HDM), cockroaches, and helminths being the best characterized. Evaluation of their allergenic activity suggests that they have a clinical impact. GST allergens belong to different classes: mu (Blo t 8, Der p 8, Der f 8, and Tyr p 8), sigma (Bla g 5 and Asc s 13), or delta (Per a 5). Also, IgE-binding molecules belonging to the pi-class have been discovered in helminths, but they are not officially recognized as allergens. In this review, we describe some aspects of the biology of GST, analyze their allergenic activity, and explore the structural aspects and clinical impact of their cross-reactivity.

scholarly journals Current view on studying of the role of tropomyiosin in the development of crossallergic reactions

2018 ◽  
Vol 15 (3) ◽  
pp. 16-24
Author(s):  
T G Fedoskova ◽  
A I Martynov ◽  
N V Kobizskaya ◽  
D V Shabanov
Keyword(s):  
House Dust ◽  
Preventive Measures ◽  
Clinical Symptoms ◽  
Cross Reactivity ◽  
House Dust Mites ◽  
Current View ◽  
Allergic Reactions ◽  
Dust Mites ◽  
High Prevalence

Cross-reactivity to proteins is the issue of the day due to the severity of clinical symptoms, high prevalence of this phenomenon and the absence of preventive measures . Cross-reactivity is found in pollen, house dust, insects, food allergy, helminthes etc. Multiple studies have confirmed the important role of the protein tropomyosin in the development of sensitization to house dust mites allergens, food allergens and insects. The presence of tropomyosin is detected in the allergen spectrum of many arthropods, in particular insects and crustaceans. The researchers have noted the possibility of development of various cross-allergic reactions to tropomyosin protein. Arthropods are the main type of the Earth’s fauna. Clinical symptoms of allergic reactions to Arthropods differ in severity; this is the issue of studying of the the cross-reactivity to tropomyosin protein.

scholarly journals IgE-dependent reactivity of canine sera from three regions of Poland

2020 ◽  
Vol 76 (06) ◽  
pp. 6410-2020
Author(s):  
BARTOSZ JANIA ◽  
MARTA DOPIERAŁA ◽  
EWA WÓJCIK ◽  
KATARZYNA RYMUZA ◽  
KATARZYNA ANDRASZEK
Keyword(s):  
House Dust ◽  
Genetic Predisposition ◽  
Dermatophagoides Pteronyssinus ◽  
House Dust Mites ◽  
Allergic Reactions ◽  
Dust Mites ◽  
Dermatophagoides Farinae ◽  
Acarus Siro ◽  
Study Support ◽  
Health Complications

Allergies in dogs have become a relatively frequent topic of discussion in veterinary surgeries. Many dogs, both purebred and of mixed breeds, are diagnosed for allergies. Allergies have many causes, from genetic predisposition to the environmental conditions in which the animal lives. Allergies in dogs are troublesome because they can lead to serious health complications when diagnosed late or left untreated. The results of the study support the hypothesis that the percentage of allergies to individual allergens varied by region (Tab. 4). Differences were observed in the case of Dermatophagoides pteronyssinus and Dermatophagoides farinae house dust mites, Acarus siro, and Tyrophagus. The remaining allergens caused allergic reactions in similar percentages of dogs from northern, central and southern Poland.

HOUSE DUST MITE ALLERGENS: FROM NATIVE EXTRACTS TO MODIFIED PREPARATIONS

2021 ◽  
Author(s):  
Anna Vasilyeva ◽  
Valentina M. Berzhets ◽  
Nina S. Petrova ◽  
Svetlana V. Khlgatian ◽  
Stanislava Yu. Petrova ◽  
...  
Keyword(s):  
House Dust ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Dermatophagoides Pteronyssinus ◽  
House Dust Mites ◽  
Dust Mites ◽  
Binding Reaction ◽  
Dust Mite ◽  
Allergenic Activity ◽  
Elisa Inhibition

The growth of allergic diseases dictates the need to develop new forms of therapeutic allergens with high immunogenic and low allergenic activity. For many years, our laboratory has been developing drugs for the diagnosis and treatment of house dust mites (HDM) allergies. The purpose of this study is to summarize the results of the five-year development of therapeutic preparations of HDM allergens. During this period, we obtained the following forms of therapeutic allergens: a granular sublingual dosage form of a mixed allergen from Dermatophagoides pteronyssinus (Der.p) and Dermatophagoides farinaе (Der.f) and a succinylated monomeric HDM allergoid Der.p. The physicochemical and immunobiological properties of the obtained preparations were studied by methods: electrophoresis in PAGE in the presence of SDS-sodium, micropoint immunoblot, ELISA, inhibition of the binding reaction of allergen-specific IgE in the sera of patients. The research results showed that the obtained preparations have a reduced allergenic and increased immunogenic activity in comparison with native extracts. The created forms of mite allergens can be further used to treat patients sensitized to HDM of the genus Dermatophagoides.

scholarly journals Group 10 Allergens (Tropomyosins) from House-Dust Mites May Cause Covariation of Sensitization to Allergens from Other Invertebrates

2012 ◽  
Vol 3 (2) ◽  
pp. ar.2012.3.0036 ◽  
Author(s):  
Rubaba Hamid Shafique ◽  
Muhammad Inam ◽  
Muhammad Ismail ◽  
Farhana Riaz Chaudhary
Keyword(s):  
House Dust ◽  
Cross Reactivity ◽  
Amino Acid Sequences ◽  
House Dust Mites ◽  
Published Data ◽  
Dust Mites ◽  
Cockroach Allergen ◽  
Ige Binding ◽  
Group 10

Group 10 allergens (tropomyosins) have been assumed to be a major cause of cross-reactivity between house-dust mites (HDMs) and other invertebrates. Despite all of the published data regarding the epidemiology, percent IgE binding and level of sensitization in the population, the role of tropomyosin as a cross-reactive allergen in patients with multiple allergy syndrome still remains to be elucidated. Homology between amino acid sequences reported in allergen databases of selected invertebrate tropomyosins was determined with Der f 10 as the reference allergen. The 66.9 and 54.4% identities were found with selected crustacean and insect species, respectively, whereas only 20.4% identity was seen with mollusks. A similar analysis was performed using reported B-cell IgE-binding epitopes from Met e1 (shrimp allergen) and Bla g7 (cockroach allergen) with other invertebrate tropomyosins. The percent identity in linear sequences was higher than 35% in mites, crustaceans, and cockroaches. The polar and hydrophobic regions in these groups were highly conserved. These findings suggest that tropomyosin may be a major cause of covariation of sensitization between HDMs, crustaceans, and some species of insects and mollusks.

179 Sensitization to house dust mites in asthmatic children in Argentina and cross-reactivity studies

1996 ◽  
Vol 97 (1) ◽  
pp. 227-227
Author(s):  
C BAENACAGNANI ◽  
E FERNANDEZCALDAS ◽  
L ARLIAN ◽  
R CODINA ◽  
M CUELLO ◽  
...  
Keyword(s):  
House Dust ◽  
Cross Reactivity ◽  
House Dust Mites ◽  
Dust Mites ◽  
Asthmatic Children

scholarly journals Tropomyosin: A panallergen that causes a worldwide allergic problem

2021 ◽  
Vol 42 (5) ◽  
pp. e145-e151
Author(s):  
Francesco Papia ◽  
Chiara Bellia ◽  
Carina Gabriela Uasuf
Keyword(s):  
Immunoglobulin E ◽  
Current Knowledge ◽  
Major Allergen ◽  
Cross Reactivity ◽  
House Dust Mites ◽  
Dust Mites ◽  
Food Allergens ◽  
Important Food ◽  
Heat Stable ◽  
Different Sources

Background: Panallergens are proteins that take part in key processes of organisms and, therefore, are ubiquitously distributed with highly conserved sequences and structures. One class of these panallergens is composed of the tropomyosins. The highly heat-stable tropomyosins comprise the major allergens in crustaceans and mollusks, which make them important food allergens in exposed populations. Tropomyosins are responsible for a widespread immunoglobulin E cross-reactivity among allergens from different sources. Allergic tropomyosins are expressed in many species, including parasites and insects. Methods: This panallergen class is divided, according to it capacity of induced allergic symptoms, into allergenic or nonallergenic tropomyosin. Although vertebrate tropomyosins share ∼55% of sequence homology with invertebrate tropomyosins, it has been thought that the invertebrate tropomyosins would not have allergic properties. Nevertheless, in recent years, this opinion has been changed. In particular, tropomyosin has been recognized as a major allergen in many insects. Results: A high grade of homology has been shown among tropomyosins from different species, such as crustaceans and insects, which supports the hypothesis of cross-reactivity among tropomyosins from divergent species. Moreover, the emerging habit of consuming edible insects has drawn the attention of allergists to invertebrate tropomyosin protein due to its potential allergenic risk. Nevertheless, evidence about tropomyosin involvement in clinical allergic response is still scarce and deserves more investigation. Conclusion: This review intended to report allergic reactions associated with different tropomyosins when considering house dust mites, parasites, seafood, and insects, and to summarize our current knowledge about its cross-reactivity because this could help physicians to accurately diagnose patients with food allergy.

scholarly journals Sensitization and Geographical Distribution of Main Aeroallergens in Iran

2018 ◽  
Author(s):  
Fardis Teifoori ◽  
Idoia Postigo ◽  
Mohammad Abtahi ◽  
Mehdi Dehghani ◽  
Jorge Martinez
Keyword(s):  
Environmental Factors ◽  
House Dust ◽  
Pollen Grains ◽  
House Dust Mites ◽  
Allergic Reactions ◽  
Preventive Strategies ◽  
Dust Mites ◽  
Animal Dander ◽  
Allergic Disorders ◽  
Ubiquitous Presence

Aeroallergens are one of the most important environmental factors that induce allergic reactions in sensitized population. Pollen grains, molds, house dust mites, and animal dander are of major concern because of their abundant sources and ubiquitous presence in environments. Identifying the allergens in geographical areas plays an important role in the diagnosis; prevention and management of allergic disorders. Here, we discussed the most common aeroallergens in Iran and suggested appropriate preventive strategies to decrease the morbidity of allergic patients. The sensitivity to the most common aeroallergens affecting Iranian population is summarized in Table 1. Further delineation of these factors is provided below

scholarly journals A novel IoT architecture for measuring and visualizing influence of common factors on house dust concentration

2021 ◽  
Vol 4 (1) ◽  
pp. 1-8
Author(s):  
Goran Đambić ◽  
Danijel Kučak ◽  
Tomislav Ražov
Keyword(s):  
House Dust ◽  
Common Factors ◽  
Dust Concentration ◽  
House Dust Mites ◽  
Allergic Reactions ◽  
Dust Mites ◽  
Airborne Dust ◽  
Allergen Source ◽  
Settled Dust ◽  
Do So

The house dust mites are considered to be an allergen source and a main cause of allergic rhinitis and allergic asthma. House dust mites, their feces and other allergens which they produce are usually major constituents of house dust. Any stir in the air causes settled dust, and therefore allergen source found in it, to become airborne and thus easier to be inhaled by people, possibly causing different kinds of allergic reactions (sneezing, for example). In this paper, the correlation between common home activities (walking around, bed making, vacuuming etc.) and airborne dust concentration is examined. In order to do so, a novel Internet of things architecture is proposed that is capable of establishing that correlation. This proposed system not only collects dust concentration but it also visualizes it in an easy to understand and interpret way.

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