Platelet-Derived Growth Factor-D Activates Complement System to Propagate Macrophage Polarization and Neovascularization
Keyword(s):
Platelet-derived growth factor-D (PDGF-D) is highly expressed in immune cells. However, the potential role of PDGF-D in immune system remains thus far unclear. Here, we reveal a novel function of PDGF-D in activating both classical and alternative complement pathways that markedly increase chemokine and cytokine responses to promote macrophage polarization. Pharmacological targeting of the complement C3a receptor using SB290157 alleviated PDGF-D-induced neuroinflammation by blocking macrophage polarization and inhibited pathological choroidal neovascularization. Our study thus suggests that therapeutic strategies targeting both PDGF-D and the complement system may open up new possibilities for the treatment of neovascular diseases.
1989 ◽
Vol 23
(2-3)
◽
pp. 209-218
◽
Keyword(s):
2011 ◽
Vol 6
(2)
◽
pp. 372-377
◽
1990 ◽
Vol 265
(9)
◽
pp. 5066-5071
Keyword(s):
2006 ◽
Vol 140
(1)
◽
pp. 28-34
◽
2003 ◽
Vol 10
(2)
◽
pp. 216-220