scholarly journals IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection

2021 ◽  
Vol 11 ◽  
Author(s):  
Isabella Quinti ◽  
Eva Piano Mortari ◽  
Ane Fernandez Salinas ◽  
Cinzia Milito ◽  
Rita Carsetti
Keyword(s):  
Inflammatory Diseases ◽  
Humoral Response ◽  
Iga Deficiency ◽  
Primary Antibody ◽  
Secretory Iga ◽  
Selective Iga Deficiency ◽  
Viral Shedding ◽  
Iga Antibodies ◽  
Epithelial Barriers ◽  
Possible Cause

A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. IgA is active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. It protects the epithelial barriers from pathogens and modulates excessive immune responses in inflammatory diseases. An early SARS-CoV-2 specific humoral response is dominated by IgA antibodies responses greatly contributing to virus neutralization. The lack of anti-SARS-Cov-2 IgA and secretory IgA (sIgA) might represent a possible cause of COVID-19 severity, vaccine failure, and possible cause of prolonged viral shedding in patients with Primary Antibody Deficiencies, including patients with Selective IgA Deficiency. Differently from other primary antibody deficiency entities, Selective IgA Deficiency occurs in the vast majority of patients as an asymptomatic condition, and it is often an unrecognized, Studies are needed to clarify the open questions raised by possible consequences of a lack of an IgA response to SARS-CoV-2.

scholarly journals IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jason R. Catanzaro ◽  
Juliet D. Strauss ◽  
Agata Bielecka ◽  
Anthony F. Porto ◽  
Francis M. Lobo ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
16S Rrna Gene Sequencing ◽  
Iga Deficiency ◽  
Secretory Iga ◽  
Rrna Gene ◽  
Healthy Controls ◽  
Microbiota Composition ◽  
Antibody Isotype ◽  
Selective Iga Deficiency ◽  
Gut Microbiota Composition

Abstract Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) in humans is often described as asymptomatic. Here, we determined the effects of IgA deficiency on human gut microbiota composition and evaluated the possibility that mucosal secretion of IgM can compensate for a lack of secretory IgA. We used 16S rRNA gene sequencing and bacterial cell sorting to evaluate gut microbiota composition and taxa-specific antibody coating of the gut microbiota in 15 sIgAd subjects and matched controls. Despite the secretion of compensatory IgM into the gut lumen, sIgAd subjects displayed an altered gut microbiota composition as compared to healthy controls. These alterations were characterized by a trend towards decreased overall microbial diversity as well as significant shifts in the relative abundances of specific microbial taxa. While secretory IgA in healthy controls targeted a defined subset of the microbiota via high-level coating, compensatory IgM in sIgAd subjects showed less specificity than IgA and bound a broader subset of the microbiota. We conclude that IgA plays a critical and non-redundant role in controlling gut microbiota composition in humans and that secretory IgA has evolved to maintain a diverse and stable gut microbial community.

Familial selective IgA deficiency with circulating anti-IgA antibodies: A distinct group of patients?

1991 ◽  
Vol 58 (1) ◽  
pp. 92-101 ◽  
Author(s):  
P.C.J. de Laat ◽  
C.M.R. Weemes ◽  
J.A.J.M. Bakkeren ◽  
F.C.A. van den Brandt ◽  
T.G.P.M. van Lith ◽  
...  
Keyword(s):  
Distinct Group ◽  
Iga Deficiency ◽  
Selective Iga Deficiency ◽  
Iga Antibodies

scholarly journals Anti-IgA antibodies against α2 and A2m (1), and defective lymphokine production in a case with selective IgA deficiency

1986 ◽  
Vol 9 (6) ◽  
pp. 507-513
Author(s):  
Naomi Wakasugi ◽  
Takayoshi Satoh ◽  
Naohiro Ozawa ◽  
Masaru Shimizu ◽  
Shigehiko Kamoshita
Keyword(s):  
Iga Deficiency ◽  
Selective Iga Deficiency ◽  
Lymphokine Production ◽  
Iga Antibodies

Anti-IgA antibodies in selective IgA deficiency and in primary immunodeficient patients treated with γ-globulin

1988 ◽  
Vol 47 (2) ◽  
pp. 199-207 ◽  
Author(s):  
Antonio Ferreira ◽  
Maria Cruz Garcia Rodriguez ◽  
Margarita Lopez-Trascasa ◽  
Dora Pascual Salcedo ◽  
Gumersindo Fontan
Keyword(s):  
Iga Deficiency ◽  
Selective Iga Deficiency ◽  
Iga Antibodies

Selective IgA deficiency associated with three organspecific autoimmune diseases, anti-IgA antibodies and erythrocyte-binding IgA

1987 ◽  
Vol 10 (3) ◽  
pp. 309-317
Author(s):  
Yukinobu Ichikawa ◽  
Mitsuaki Uchiyama ◽  
Shigeru Arimori ◽  
Junichi Ogawa ◽  
Hiroshi Inoue ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Iga Deficiency ◽  
Selective Iga Deficiency ◽  
Iga Antibodies ◽  
Erythrocyte Binding

scholarly journals IgA-deficient humans exhibit gut microbiota dysbiosis despite production of compensatory IgM

2018 ◽  
Author(s):  
Jason R Catanzaro ◽  
Juliet D Strauss ◽  
Agata Bielecka ◽  
Anthony F Porto ◽  
Francis M Lobo ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
16S Rrna Gene Sequencing ◽  
Iga Deficiency ◽  
Secretory Iga ◽  
Intestinal Lumen ◽  
Rrna Gene ◽  
Microbiota Composition ◽  
Antibody Isotype ◽  
Selective Iga Deficiency ◽  
Gut Microbiota Composition

ABSTRACTImmunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) is the most common primary immunodeficiency in humans and is often described as asymptomatic. Here, we determined the effects of IgA deficiency on human gut microbiota composition and evaluated the possibility that secretion of IgM can compensate for a lack of secretory IgA. We used 16S rRNA gene sequencing and bacterial cell sorting to evaluate gut microbiota composition and IgA or IgM coating of the gut microbiota in 15 sIgAd subjects and 15 matched controls. Although sIgAd subjects secreted a significant amount of IgM into the intestinal lumen, this was insufficient to fully compensate for the lack of secretory IgA. Indeed, sIgAd subjects displayed an altered gut microbiota composition as compared to healthy controls, which was characterized by a trend towards decreased overall microbial diversity and significant shifts in the relative abundances of specific microbial taxa. While IgA targets a defined subset of the microbiota via high-level coating, compensatory IgM binds a broader subset of the microbiota in a less targeted manner. We conclude that IgA plays a critical and non-redundant role in controlling gut microbiota composition in humans and that secretory IgA has evolved to maintain a diverse and stable gut microbial community that promotes human health, enhances resistance to infection, and is resilient to perturbation.

scholarly journals Selective IgA Deficiency and Allergy: A Fresh Look to an Old Story

Medicina ◽  
2022 ◽  
Vol 58 (1) ◽  
pp. 129
Author(s):  
Bianca Laura Cinicola ◽  
Federica Pulvirenti ◽  
Martina Capponi ◽  
Marta Bonetti ◽  
Giulia Brindisi ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Atopic Disease ◽  
Iga Deficiency ◽  
Normal Serum ◽  
Secretory Iga ◽  
Primary Immune Deficiency ◽  
Recurrent Infections ◽  
Selective Iga Deficiency ◽  
The Relationship ◽  
Allergic Disorders

Selective IgA deficiency (SIgAD) is the most common human primary immune deficiency (PID). It is classified as a humoral PID characterized by isolated deficiency of IgA (less than 7 mg/dL but normal serum IgG and IgM) in subjects greater than 4 years of age. Intrinsic defects in the maturation of B cells and a perturbation of Th cells and/or cytokine signals have been hypothesized to contribute to SIgAD pathogenesis. The genetic basis of IgA deficiency remains to be clarified. Patients with SIgAD can be either asymptomatic or symptomatic with clinical manifestations including allergy, autoimmunity and recurrent infections mainly of the respiratory and gastrointestinal tract. Studies analyzing allergy on SIgAD patients showed prevalence up to 84%, supporting in most cases the relationship between sIgAD and allergic disease. However, the prevalence of allergic disorders may be influenced by various factors. Thus, the question of whether allergy is more common in SIgAD patients compared to healthy subjects remains to be defined. Different hypotheses support an increased susceptibility to allergy in subjects with SIgAD. Recurrent infections due to loss of secretory IgA might have a role in the pathogenesis of allergy, and vice versa. Perturbation of microbiota also plays a role. The aim of this review is to examine the association between SIgAD and atopic disease and to update readers on advances over time at this important interface between allergy and SIgAD.

Sign in / Sign up

Export Citation Format

Share Document