scholarly journals Matrix Metalloproteinase 2 Is Associated With Secondary Caries Independent From the Restorative Material

2021 ◽  
Vol 2 ◽  
Author(s):  
Merve Benli ◽  
Luiza Arieta Frota de Souza ◽  
Kathleen Deeley ◽  
Adriana Modesto ◽  
Alexandre R. Vieira
Keyword(s):  
Matrix Metalloproteinase 2 ◽  
Restorative Material ◽  
Common Allele ◽  
Chi Square ◽  
Secondary Caries ◽  
University Of Pittsburgh ◽  
Point Analysis ◽  
The University ◽  
Pittsburgh School

Certain patients, despite receiving proper treatment, still show higher failure rates of restorative dental treatments. The aim of this work was to test if MMP2 and MMP3 alleles are overrepresented in individuals with secondary caries. A total of 1,089 individuals from the University of Pittsburgh School of Dental Medicine Dental Registry and DNA Repository project were selected for this study. From this total, 341 individuals were selected for having a record of secondary caries in any type of restoration and were matched with 748 individuals by sex, age, ethnicity, and restorative work in the same teeth that did not fail. Genomic DNA extracted from saliva was used to obtain genotypes in five markers of MMP2 and MMP3 using TaqMan chemistry and end-point analysis. Chi-square was used to test if differences in allele and genotype distributions were statistically different at an alpha of 0.05. The less common allele and homozygote genotype of MMP2 rs9923304 were less commonly found among individuals with secondary caries. The less common allele of MMP2 rs2287074 was also less frequent among individuals with secondary caries. These results provide statistical evidence for the role of MMP2 in failure of restorations due to secondary caries. We can conclude that MMP2 variation impacts the risk of having secondary caries, independent of the restorative material.

scholarly journals Oral candidiasis: relation to systemic diseases and medications

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Xiaozhu Chu
Keyword(s):  
Candida Albicans ◽  
Oral Candidiasis ◽  
Host Tissue ◽  
Mental Illnesses ◽  
Systemic Diseases ◽  
Oral Flora ◽  
University Of Pittsburgh ◽  
The University ◽  
Pittsburgh School

Background: Oral candidiasis is by far the most common oral fungal infection in humans. It is caused by the fungal organism Candida albicans. When the host is debilitated by other diseases and conditions, C. albicans, which is usually a part of the normal oral flora, can turn pathogenic and invade the host tissue to cause the infection. The purpose of this paper is to investigate the role of systemic diseases and medications in the development of oral candidiasis.Methods: A total of 12 cases with code indicating oral candidiasis were collected from the University of Pittsburgh School of Dental Medicine Dental Registry and DNA Repository. The systemic diseases and medications were descriptively analyzed.Results: 50% of the subjects had more than two systemic diseases. The most prevalent diseases were mental illnesses (50%), cardiovascular diseases (41.7%), and respiratory system diseases (33.3%). 50% of subjects were on polypharmacy therapies and 75% of subjects were taking medications that may contribute to oral candidiasis. Among the medications, antidepressants and inhalational corticosteroids may have strong potentials to cause oral candidiasis.Conclusion: Oral candidiasis is associated with having systemic diseases and intake of medication, especially with those medications can cause xerostomia. As the number of systemic diseases and medications increases, the risk of developing oral candidiasis may increase too.

Advancing Practice, Instruction, and Innovation Through Informatics (APIII 2005): Scientific Poster Session Abstracts

2006 ◽  
Vol 130 (6) ◽  
pp. 890-903
Keyword(s):  
Poster Session ◽  
University Of Pittsburgh ◽  
School Of Medicine ◽  
Pathology Informatics ◽  
Poster Sessions ◽  
Scientific Poster ◽  
The University ◽  
Development Center ◽  
Annual International Conference ◽  
Pittsburgh School

Abstract Scientific poster sessions (http://apiii.upmc.edu/abstracts/index.html) were conducted at the 10th annual international conference on Advancing Practice, Instruction, and Innovation Through Informatics (APIII 2005) on August 24–26, 2005, at Lake Tahoe, Calif. One of the course directors was Michael J. Becich, MD, PhD, professor of pathology and information sciences and telecommunications, director of the Center for Pathology Informatics, and director of Benedum Oncology Informatics Center at the University of Pittsburgh School of Medicine, Pittsburgh, Pa. Also serving as course director was John R. Gilbertson, MD, director of research and development, Center for Pathology Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pa.

Advancing Pathology Informatics, Imaging, and the Internet (APIII 2001)

2002 ◽  
Vol 126 (7) ◽  
pp. 781-802
Keyword(s):  
Poster Session ◽  
Associate Professor ◽  
The Internet ◽  
University Of Pittsburgh ◽  
National Conference ◽  
School Of Medicine ◽  
Pathology Informatics ◽  
The University ◽  
Pittsburgh School ◽  
Information Sciences

Abstract Scientific and E-Poster Session AbstractsScientific (http://apiii.upmc.edu/apiii2001) and E-poster (http://apiii.upmc.edu/apiii2001) sessions were conducted at the sixth national conference on Advancing Pathology Informatics, Imaging, and the Internet (APIII 2001) on October 3–5, 2001, in Pittsburgh, Pa. The course director was Michael J. Becich, MD, PhD, Associate Professor of Pathology and Information Sciences & Telecommunications, Director of the Center for Pathology Informatics at the University of Pittsburgh School of Medicine, and Director of Benedum Oncology Informatics Center.

scholarly journals The Role of Community Coordinated Efforts in Combating the Opioid Overdose Crisis: The Pennsylvania Opioid Overdose Reduction Technical Assistance Center

Commonwealth ◽  
2018 ◽  
Vol 20 (2-3) ◽  
Author(s):  
Lynn S. Mirigian ◽  
Marco F. Pugliese ◽  
Janice L. Pringle ◽  
Monica F. Gaydos
Keyword(s):  
Technical Assistance ◽  
Research Unit ◽  
Opioid Overdose ◽  
Implementation Framework ◽  
University Of Pittsburgh ◽  
Implementation Evaluation ◽  
Data Assessment ◽  
The University ◽  
Safety First

The Pennsylvania Opioid Overdose Reduction Technical Assistance Center (TAC) was developed by the University of Pittsburgh, School of Pharmacy, Program Evaluation and Research Unit (PERU) and funded by the Pennsylvania Commission on Crime and Delinquency (PCCD) in response to the need for local coordination and supported efforts to address the growing number of opioid overdoses in Pennsylvania. This article outlines the TAC’s initiatives to address this crisis in 42 counties across the Commonwealth of Pennsylvania, stressing the importance of communication and collaboration both within and between communities, such as public health, public safety, first responders, physicians, the criminal justice system, and families. The TAC uses the Implementation Framework (IF) developed by Dr. Janice Pringle to achieve accurate data assessment and the effective implementation, evaluation, and sustainability of programs.

scholarly journals Caries is Associated with Asthma and Epilepsy

2009 ◽  
Vol 03 (04) ◽  
pp. 297-303 ◽  
Author(s):  
Ida Anjomshoaa ◽  
Margaret E. Cooper ◽  
Alexandre R. Vieira
Keyword(s):  
Gender Differences ◽  
Regression Analysis ◽  
Health Behaviors ◽  
Disease Status ◽  
Caries Experience ◽  
Systemic Diseases ◽  
University Of Pittsburgh ◽  
The University ◽  
Oral Conditions ◽  
Pittsburgh School

ABSTRACTObjectives: There is evidence of association between systemic diseases and oral conditions, although it is not clear if these are direct or mediated by underlying factors such as health behaviors. The aim of this work was to evaluate whether self-reported systemic diseases were associated with caries experience.Methods: Medical history data and caries experience (DMFT and DMFS; Decayed, Missing due to caries, Filled Teeth/Surface) were obtained from the University of Pittsburgh School of Dental Medicine Dental Registry and DNA Repository. Information on 318 subjects (175 females and 143 males) was evaluated. Regression analysis was used to test for association between caries experience and disease status.Results: The stronger associations were found between caries experience and asthma and epilepsy. With respect to asthma, DMFT above 15 (R2 = 0.04) and DMFS above 50 (R2 = 0.02) were associated. After controlling for gender differences in asthma, the associations remained strong (R2 = 0.05 for both DMFT and DMFS). For epilepsy, DMFT above 15 (R2 = 0.18) and DMFS above 50 (R2 = 0.14) were associated.Conclusions: Asthma and epilepsy are associated with higher caries experience. (Eur J Dent 2009;3:297-303)

Reading and writing for healers

2017 ◽  
Vol 5 (4) ◽  
pp. 534
Author(s):  
Zsuzsa Horvath ◽  
Cynthia Salter ◽  
Judith Resick ◽  
Xiaohan Fan ◽  
Tanvi Mehta ◽  
...  
Keyword(s):  
Clinical Care ◽  
Narrative Medicine ◽  
Reflective Writing ◽  
University Of Pittsburgh ◽  
Written Text ◽  
Book Discussion ◽  
Event Series ◽  
Centered Care ◽  
The University

Aims, background and objectives: A growing body of research demonstrates that teaching close-reading and reflective writing to clinicians improves their ability to provide patient- and person-centered care. Through narrative medicine workshops, providers gain skills that can improve relationships with patients, increase empathy among clinicians and enhance clinical care. The goal of the event series (book discussion and reflective writing sessions) offered at the University of Pittsburgh School of Dental Medicine, USA was to provide participants an interactive opportunity to practise and reflect upon the basic tenets of narrative medicine. Methods: The objectives were to recognize how a written text can inform and enhance empathetic and humanistic thinking and to develop an increased appreciation for the importance of humanistic thinking in healthcare. The goal of this article was to share the outcomes of a unique program, which was offered in an interprofessional setting and organized by collaborators across disciplines within and outside of the healthcare professions. To evaluate the overall effectiveness of the introductory presentation, book discussion and reflective writing sessions, anonymous surveys were employed to study participants’ perception about the role of literature in healthcare, the role of reflection in the provision of care and insights gained in the sessions. Results: The study revealed overwhelmingly positive responses by the participants to the programming. Qualitative data analysis revealed multiple areas of learning. Discussion and Conclusion: Due to the success of the workshop series, the School of Dental Medicine will offer the event again and expects it to become a sustained yearly event that fosters collaborations across different schools of the University.

scholarly journals The Innovation Opportunity in Pharmacy Education Standards

2017 ◽  
Vol 8 (3) ◽  
pp. 8 ◽  
Author(s):  
Ravi M Patel
Keyword(s):  
Pharmacy Education ◽  
Education Standards ◽  
University Of Pittsburgh ◽  
The Rich ◽  
The University ◽  
Pittsburgh School

The changing landscape of healthcare and recent formal Standards for innovation in pharmacy education presents a unique opportunity. To realize this opportunity, pharmacy should learn from the successes of other fields to make use of the rich environment for improvement in healthcare. The University of Pittsburgh School of Pharmacy presents one example of a Program that utilizes a curriculum, projects, and partners to realize innovation. Educators in pharmacy can make use of the opportunity for innovation by learning from successful examples and embracing the process’s challenges of iteration.   Type: Commentary

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